Energy Density of Vortices in the Schroedinger Picture

The one-loop energy density of an infinitely thin static magnetic vortex in SU(2) Yang-Mills theory is evaluated using the Schroedinger picture. Both the gluonic fluctuations as well as the quarks in the vortex background are included. The energy density of the magnetic vortex is discussed as a function of the magnetic flux. The center vortices correspond to local minima in the effective potential. These minima are degenerated with the perturbative vacuum if the fermions are ignored. Inclusion of fermions lifts this degeneracy, raising the vortex energy above the energy of the perturbative vacuum.Comment: 25 pages, 2 figure

On the spectrum of QCD(1+1) with large numbers of flavours N_F and colours N_C near N_F/N_C = 0

QCD(1+1) in the limit of a large number of flavours N_F and a large number of colours N_C is examined in the small N_F/N_C regime. Using perturbation theory in N_F/N_C, stringent results for the leading behaviour of the spectrum departing from N_F/N_C = 0 are obtained. These results provide benchmarks in the light of which previous truncated treatments of QCD(1+1) at large N_F and N_C are critically reconsidered.Comment: 6 revtex page

One-dimensional classical adjoint SU(2) Coulomb Gas

The equation of state of a one-dimensional classical nonrelativistic Coulomb gas of particles in the adjoint representation of SU(2) is given. The problem is solved both with and without sources in the fundamental representation at either end of the system. The gas exhibits confining properties at low densities and temperatures and deconfinement in the limit of high densities and temperatures. However, there is no phase transition to a regime where the string tension vanishes identically; true deconfinement only happens for infinite densities and temperatures. In the low density, low temperature limit, a new type of collective behavior is observed.Comment: 6 pages, 1 postscript figur

Signals of confinement in Green functions of SU(2) Yang-Mills theory

The vortex picture of confinement is employed to explore the signals of confinement in Yang-Mills Green functions. By using SU(2) lattice gauge theory, it has been well established that the removal of the center vortices from the lattice configurations results in the loss of confinement. The running coupling constant, the gluon and the ghost form factors are studied in Landau gauge for both cases, the full and the vortex removed theory. In the latter case, a strong suppression of the running coupling constant and the gluon form factor at low momenta is observed. At the same time, the singularity of the ghost form factor at vanishing momentum disappears. This observation establishes an intimate correlation between the ghost singularity and confinement. The result also shows that a removal of the vortices generates a theory for which Zwanziger's horizon condition for confinement is no longer satisfied.Comment: 4 pages, 4 figure

Cryo-electron microscopy of an extremely halophilic microbe: technical aspects

Most halophilic Archaea of the class Halobacteriaceae depend on the presence of several molar sodium chloride for growth and cell integrity. This poses problems for structural studies, particularly for electron microscopy, where the high salt concentration results in diminished contrast. Since cryo-electron microscopy of intact cells provides new insights into the cellular and molecular organization under close-to-live conditions, we evaluated strategies and conditions to make halophilic microbes available for investigations in situ. Halobacterium salinarum, the test organism for this study, usually grows at 4.3 M NaCl. Adaptation to lower concentrations and subsequent NaCl reduction via dialysis led to still vital cells at 3 M salt. A comprehensive evaluation of vitrification parameters, thinning of frozen cells by focused-ion-beam micromachining, and cryo-electron microscopy revealed that structural studies under high salt conditions are possible in situ

The intrinsic strangeness and charm of the nucleon using improved staggered fermions

We calculate the intrinsic strangeness of the nucleon, - , using the MILC library of improved staggered gauge configurations using the Asqtad and HISQ actions. Additionally, we present a preliminary calculation of the intrinsic charm of the nucleon using the HISQ action with dynamical charm. The calculation is done with a method which incorporates features of both commonly-used methods, the direct evaluation of the three-point function and the application of the Feynman- Hellman theorem. We present an improvement on this method that further reduces the statistical error, and check the result from this hybrid method against the other two methods and find that they are consistent. The values for and found here, together with perturbative results for heavy quarks, show that dark matter scattering through Higgs-like exchange receives roughly equal contributions from all heavy quark flavors.Comment: 17 pages, 14 figure

A Minimum-Labeling Approach for Reconstructing Protein Networks across Multiple Conditions

The sheer amounts of biological data that are generated in recent years have driven the development of network analysis tools to facilitate the interpretation and representation of these data. A fundamental challenge in this domain is the reconstruction of a protein-protein subnetwork that underlies a process of interest from a genome-wide screen of associated genes. Despite intense work in this area, current algorithmic approaches are largely limited to analyzing a single screen and are, thus, unable to account for information on condition-specific genes, or reveal the dynamics (over time or condition) of the process in question. Here we propose a novel formulation for network reconstruction from multiple-condition data and devise an efficient integer program solution for it. We apply our algorithm to analyze the response to influenza infection in humans over time as well as to analyze a pair of ER export related screens in humans. By comparing to an extant, single-condition tool we demonstrate the power of our new approach in integrating data from multiple conditions in a compact and coherent manner, capturing the dynamics of the underlying processes.Comment: Peer-reviewed and presented as part of the 13th Workshop on Algorithms in Bioinformatics (WABI2013

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators?

Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription ( STAT) 3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone ( ACTH) secretion were determined. Results: Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor ( CNTF) and novel neurotrophin1/B-cell stimulating factor-3 (CNTFRalpha/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. Conclusion: (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIFR/gp130 (OSMR type I) but not OSMR/gp130 (OSMR type II) are involved in corticotroph signaling. (iv) CT-1 has the hitherto unknown ability to stimulate corticotroph function, and (v) despite redundant immuno-neuroendocrine effects of different gp130 cytokines, corticotroph cells are preferably activated through the LIFR and CNTFR complexes. Copyright (C) 2004 S. Karger AG, Basel

On the Spectrum of QCD(1+1) with SU(N_c) Currents

Extending previous work, we calculate in this note the fermionic spectrum of two-dimensional QCD (QCD_2) in the formulation with SU(N_c) currents. Together with the results in the bosonic sector this allows to address the as yet unresolved task of finding the single-particle states of this theory as a function of the ratio of the numbers of flavors and colors, \lambda=N_f/N_c, anew. We construct the Hamiltonian matrix in DLCQ formulation as an algebraic function of the harmonic resolution K and the continuous parameter \lambda. Amongst the more surprising findings in the fermionic sector chiefly considered here is that the fermion momentum is a function of \lambda. This dependence is necessary in order to reproduce the well-known 't Hooft and large N_f spectra. Remarkably, those spectra have the same single-particle content as the ones in the bosonic sectors. The twist here is the dramatically different sizes of the Fock bases in the two sectors, which makes it possible to interpret in principle all states of the discrete approach. The hope is that some of this insight carries over into the continuum. We also present some new findings concerning the single-particle spectrum of the adjoint theory.Comment: 21 pp., 13 figures, version published in PR