Problem-Based Learning Of Heuristic Methods For Decision Problems In Mathematics, Computer Science And Industrial Engineering

In a digitalized world, most processes can be formalised, measured and described mathematically. The use of analytical methods to optimise such models and decisions constitutes operational research (OR), developing new methods for a specific problem and analysing them are part of discrete optimisation (DO). However, there is limited research on OR and application driven DO in higher education. Furthermore, neither is well integrated into engineering education research. In this work, we present a case study of an interdisciplinary Master’s course on heuristic methods in the context of OR and DO. We discuss to what extent wellestablished approaches from engineering education practice, such as ProblemBased Learning, are applicable. Furthermore, we introduce two practical cases and argue that due to its application-oriented nature, OR and DO specifically stimulate independent student work. Results from evaluations, minute papers and student coursework indicate that the teaching approach successfully contributed to students’ achievement of the intended learning outcomes. To further foster discussion, we not only provide the lecture notes publicly, but also all tutorial and project case data to instructors upon request under a CC BY-NC license

Like It or Not : When Corporate Social Responsibility Does Not Attract Potential Applicants

Companies increasingly recognize the importance of communicating corporate social responsibility (CSR) including their engagement toward employees, the community, the environment and other stakeholder groups to attract applicants. The positive findings on the effect of CSR on applicants' reactions are commonly based on the assumption that companies send a clear signal about their commitment to CSR. However, communication is always contextualized and has become more ambiguous through the increased availability of information online. External stakeholders including actual and potential applicants are confronted with inconsistencies between the way companies communicate CSR activities and their overall CSR performance. Drawing on signaling theory, this article raises the question of how the interaction between strong CSR communication and low CSR performance influences organizational attractiveness. We propose that low CSR performance dampens the effect of CSR communication on organizational attractiveness. Hence, the inconsistency between CSR communication and CSR performance decreases organizational attractiveness. To test our hypotheses, we scraped 67,189 posts published on corporate Facebook career pages by 58 Fortune 500 companies from the time they began their respective career page until June 2018. Surprisingly, our results show that a low CSR performance strengthens the effect of CSR communication on organizational attractiveness. Thus, inconsistencies between CSR communication and CSR performance seem to lead to positive evaluations among applicants

Skunk River Review Fall 2004, vol 16

https://openspace.dmacc.edu/skunkriver/1012/thumbnail.jp

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic hyperexcitability. Axonal Kv7 (outward-rectifying) and oligodendroglial Kir4.1 (inward-rectifying) potassium channels have important roles in regulating neuronal excitability at and around the nodes of Ranvier. Here, we studied the spatial and functional relationship between neuronal Kv7 and oligodendroglial Kir4.1 channels and assessed the transcriptional and functional signatures of cortical and retinal projection neurons under physiological and inflammatory demyelinating conditions. We found that both channels became dysregulated in MS and experimental autoimmune encephalomyelitis (EAE), with Kir4.1 channels being chronically downregulated and Kv7 channel subunits being transiently upregulated during inflammatory demyelination. Further, we observed that pharmacological Kv7 channel opening with retigabine reduced neuronal hyperexcitability in human and EAE neurons, improved clinical EAE signs, and rescued neuronal pathology in oligodendrocyte-Kir4.1-deficient (OL-Kir4.1-deficient) mice. In summary, our findings indicate that neuron-OL compensatory interactions promoted resilience through Kv7 and Kir4.1 channels and identify pharmacological activation of nodal Kv7 channels as a neuroprotective strategy against inflammatory demyelination

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd

Parenting as a choice: motivational factors and changes couples experience during the transition to parenthood

Includes bibliographical references