A Theoretical Information Approach to Ring and Total Aromaticity in Ground and Excited States

Applying the Shannon equation to the density matrix of a molecule, an information index is specified for the quantitative estimation of the ring and total aromaticity of molecules in ground · and excited states. The approach is applicable within each LCAO- method. The information index reproduces well the classification of molecules as aromatic, nonaromatic, and antiaromatic. It also correlates with results of other authors obtained by radically different approaches. A tendency is found for the aromaticity of aromatic molecules to decrease and of antiaromatic molecules to increase when the molecule is excited to the S1-state

Early Neuroendoscope-assisted Evacuation of Spontaneous Intracranial Hematomas. Preliminary Report

Purpose: The surgical techniques, effectiveness and indications of microsurgical neuroendoscopic assisted evacuation of spontaneous intracranial hematomas (SICH) is still uncertain. This minimal invasive technique remains investigational and controversal with regard to patient selection, timing of operation and method of the management. The purpose of this study was to investigate the early postoperative results in patients with SICH underwent endoscopic evacuation and to give evaluation and eventual prognosis of the clinical outcomes after this procedure.Material and Methods: A retrospective analysis of 56 patients SICH treated in the Neurosurgical clinic with endoscopic assisted evacuation was performed. Hematoma volume and its localization (subcortical – 11 patients, in basal ganglia – 12 – 7 of them with propagation to ventricular system, 6 infratentorial and 27 subdural), comorbidity, clinical featuresand timing of surgical procedures was made. The GCS rate by admission and GOS by discharging of patients was analyzed, also the postoperative complications and causes of death. Results: 52 patients (92, 9%) were operated within the first 24 hours of the onset. Patients operated between the 12 and 24 hours had better outcome in comparison to these operated after the 24 hours period. The authors analyzed their experience with endoscopic technique, effectiveness of the method, results and complications. Mortality rate in our series was 23,2% (13 patients). The causes of surgical complications and causes of death were analyzed.Conclusion: The endoscopic assisted evacuation of SICH is a short, safe and very effective method when the surgical procerure is provided within the first 12–24 hours. Our results showed that early and complete evacuation of hematoma volume may promote to recovery of the general condition of the patient and improved outcomes

SORPTIVE PROPERTIES OF NATURAL MINERAL SORBENT TOWARDS HEPATITIS-B-SURFACE ANTIGEN

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A Theoretical Information Approach to Ring and Total Aromaticity in Ground and Excited States

Applying the Shannon equation to the density matrix of a molecule, an information index is specified for the quantitative estimation of the ring and total aromaticity of molecules in ground · and excited states. The approach is applicable within each LCAO- method. The information index reproduces well the classification of molecules as aromatic, nonaromatic, and antiaromatic. It also correlates with results of other authors obtained by radically different approaches. A tendency is found for the aromaticity of aromatic molecules to decrease and of antiaromatic molecules to increase when the molecule is excited to the S1-state

Cytotoxic and genotoxic effects of Br-containing oxaphosphole on Allium cepa L. root tip cells and mouse bone marrow cells

The continuous production and release of chemicals into the environment has led to the need to assess their genotoxicity. Numerous organophosphorus compounds with different structures have been synthesized in recent years, and several oxaphosphole derivatives are known to possess biological activity. Such chemical compounds may influence proliferating cells and cause disturbances of the genetic material. In this study, we examined the cytotoxicity and genotoxicity of 4-bromo-N,N-diethyl-5,5-dimethyl-2,5-dihydro-1,2-oxaphosphol-2-amine 2-oxide (Br-oxph). In A. cepa cells, Br-oxph (10-9 M, 10 -6 M and 10 -3 M) reduced the mitotic index 48 h after treatment with the two highest concentrations, with no significant effect at earlier intervals. Mitotic cells showed abnormalities 24 h and 48 h after treatment with the two lowest concentrations but there were no consistent changes in interphase cells. Bone marrow cells from mice treated with Br-oxph (2.82 x 10 -3 μg/kg) also showed a reduced mitotic index after 48 h and a greater percentage of cells with aberrations (principally chromatid and isochromatid breaks). These findings indicate the cytotoxicity and genotoxicity of Br-oxph in the two systems studied

Artificial intelligence – the new suggestion for biomedicine, dentistry and healthcare

The development of technologies based on Artificial Intelligence (AI) and their application in medicine is growing rapidly. Innovations in digital technology, telemedicine, 5G technology and artificial intelligence (AI) create new opportunities for the development of the healthcare system. The aim of the present study is to explore the possibilities for the application of artificial intelligence in biomedicine, dentistry, healthcare and healthcare. In recent years there have been many major innovations, including the introduction of many new information and communication technologies. Digital innovations, including the further inclusion of telemedicine, the development of 5th generation wireless networks (5G) and artificial intelligence (AI) approaches, create an exceptional ecosystem for new health opportunities. The digital health sector creates a favorable environment for the provision of health services at a very high level

A mechanism for the suppression of homologous recombination in G1 cells

DNA repair by homologous recombination (HR)(1) is highly suppressed in G1 cells(2,3) to ensure that mitotic recombination occurs solely between sister chromatids(4). Although many HR factors are cell cycle-regulated, the identity of the events that are both necessary and sufficient to suppress recombination in G1 cells is unknown. Here we report that the cell cycle controls the interaction of BRCA1 with PALB2-BRCA2 in order to constrain BRCA2 function to the S/G2 phases. We found that the BRCA1-interaction site on PALB2 is targeted by an E3 ubiquitin ligase composed of KEAP1, a PALB2-interacting protein(5), in complex with CUL3-RBX1(6). PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11, which is itself under cell cycle control. Restoration of the BRCA1-PALB2 interaction combined with the activation of DNA end resection is sufficient to induce HR in G1, as measured by RAD51 recruitment, unscheduled DNA synthesis and a CRISPR/Cas9-based gene targeting assay. We conclude that the mechanism prohibiting HR in G1 minimally consists of the suppression of DNA end resection coupled to a multi-step block to BRCA2 recruitment to DNA damage sites that involves the inhibition of BRCA1-PALB2-BRCA2 complex assembly. We speculate that the ability to induce HR in G1 cells with defined factors could spur the development of gene targeting applications in non-dividing cells

Time separation as a hidden variable to the Copenhagen school of quantum mechanics

The Bohr radius is a space-like separation between the proton and electron in the hydrogen atom. According to the Copenhagen school of quantum mechanics, the proton is sitting in the absolute Lorentz frame. If this hydrogen atom is observed from a different Lorentz frame, there is a time-like separation linearly mixed with the Bohr radius. Indeed, the time-separation is one of the essential variables in high-energy hadronic physics where the hadron is a bound state of the quarks, while thoroughly hidden in the present form of quantum mechanics. It will be concluded that this variable is hidden in Feynman's rest of the universe. It is noted first that Feynman's Lorentz-invariant differential equation for the bound-state quarks has a set of solutions which describe all essential features of hadronic physics. These solutions explicitly depend on the time separation between the quarks. This set also forms the mathematical basis for two-mode squeezed states in quantum optics, where both photons are observable, but one of them can be treated a variable hidden in the rest of the universe. The physics of this two-mode state can then be translated into the time-separation variable in the quark model. As in the case of the un-observed photon, the hidden time-separation variable manifests itself as an increase in entropy and uncertainty.Comment: LaTex 10 pages with 5 figure. Invited paper presented at the Conference on Advances in Quantum Theory (Vaxjo, Sweden, June 2010), to be published in one of the AIP Conference Proceedings serie

Neddylation inhibition upregulates PD‐L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149569/1/ijc32379_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149569/2/ijc32379-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149569/3/ijc32379.pd