15 research outputs found
Poly (4-vinylpyridine) and polyaniline: As efficient and commercial available basic catalysts for the synthesis of N-amino-2-pyridones under thermal conditions or microwave irradiation
Poly (4-vinylpyridine) and polyaniline as highly effective base catalysts have catalyzed the three-component reaction of an appropriate aldehyde, cyanoacetic acid hydrazide and malononitrile to prepare of the corresponding N-amino-2-pyridone derivatives. These reactions occur in ethanol at reflux or under microwave heating, in the presence of the base catalysts, are inexpensive and easily obtained with consistent activity
Bis[N-cyclohexyl-1-(2-{1-[(cyclohexylamino)carbonyl]cyclohexyl}-3,5-dioxo-1,2-oxazolidin-4-yl)cyclopentanecarboxamide] monohydrate
The reaction of cyclohexyl isocyanide and alkylidene Meldrum’s acid (systematic name 2,2-dimethyl-1,3-dioxane-4,6-dione) in the presence of cyclohexyl ketoxime and dichloromethane as solvent resulted in the title compound, 2C28H43N3O5·H2O. One methylene group of the cyclopentane ring was found to be disordered and was refined with occupancies 0.75:0.25. Intramolecular N—H⋯O hydrogen bonds occur. The crystal structure is stabilized by intermolecular N—H⋯O and O—H⋯O hydrogen bonds
A convenient one-pot synthesis of novel tetraamides via 2-cyclopentylidenemalonic acid based Ugi-four component reaction
AbstractA mild and efficient Ugi four component condensation reaction was developed among aromatic aldehydes, aromatic amines, isocyanides and 2-cyclopentylidenemalonic acid to prepare a new series of N1,N3-bis((cyclohexylcarbamoyl)(phenyl)methyl)-2-cyclopentylidene-N1,N3-diphenylmalonamide derivatives. These one-pot reactions led to the construction of four amide groups with easy recovery of the desired products
Design and effective synthesis of novel furo[2,3-d]pyrimidine derivatives containing ethylene ether spacers
[1+4] Cycloaddition reaction of ethylene ether-based N,N-dimethybenzylidenebarbituric acid with alkyl isocyanide in DMF produced novel high substituted furo[2,3-d]pyrimidine derivatives containing ether spacers under mild reaction conditions. The structures of the products were deduced from their IR, 1H NMR, and 13C NMR spectroscopy. Good antibacterial activity was found in compound 5c
Design and effective synthesis of novel furo[2,3-d]pyrimidine derivatives containing ethylene ether spacers
Abstract[1+4] Cycloaddition reaction of ethylene ether-based N,N-dimethybenzylidenebarbituric acid with alkyl isocyanide in DMF produced novel high substituted furo[2,3-d]pyrimidine derivatives containing ether spacers under mild reaction conditions. The structures of the products were deduced from their IR, 1H NMR, and 13C NMR spectroscopy. Good antibacterial activity was found in compound 5c
Synthesis of novel tetrahydroquinoline derivatives from α,α′-bis(substituted-benzylidene)cycloalkanones
In this paper, we describe a two-step synthesis of a series of substituted tetrahydroquinoline analogies. In the first step α,α′-bis(substituted-benzylidene)cycloalkanones are reacted with malononitrile to afford 2-amino-3-cyano-4H-pyrans. The second step involves the conversion of pyrans into 2-amino-5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives using NH4OAC
DataSheet1_Synthesis and characterization of an Fe-MOF@Fe3O4 nanocatalyst and its application as an organic nanocatalyst for one-pot synthesis of dihydropyrano[2,3-c]chromenes.DOCX
In this study, the recyclable heterogeneous cluster bud Fe-MOF@Fe3O4 ‘nanoflower’ composite (CB Fe-MOF@Fe3O4 NFC) was successfully synthesized using Fe(NO3)3·9H2O, 8-hydroxyquinoline sulfate monohydrate, and Fe3O4 nanoparticles by microwave irradiation. The as-prepared CB Fe-MOF@Fe3O4 NFC was characterized by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), vibrational sampling magnetometry (VSM), and Fourier transform infrared spectroscopy (FTIR). The CB Fe-MOF@Fe3O4 NFC samples proved to have excellent catalytic activity. The activity of the CB Fe-MOF@Fe3O4 NFC nanocatalyst was explored in the synthesis of dihydropyrano[3, 2-c]chromene derivatives via a three-component reaction of 4-hydroxycoumarin, malononitrile, and a wide range of aromatic aldehyde compounds. Optimized reaction conditions had several advantages, including the use of water as a green solvent, environmental compatibility, simple work-up, reusability of the catalyst, low catalyst loading, faster reaction time, and higher yields.</p
A convenient one-pot synthesis of novel tetraamides via 2-cyclopentylidenemalonic acid based Ugi-four component reaction
A mild and efficient Ugi four component condensation reaction was developed among aromatic aldehydes, aromatic amines, isocyanides and 2-cyclopentylidenemalonic acid to prepare a new series of N1,N3-bis((cyclohexylcarbamoyl)(phenyl)methyl)-2-cyclopentylidene-N1,N3-diphenylmalonamide derivatives. These one-pot reactions led to the construction of four amide groups with easy recovery of the desired products
Synthesis of pyridone derivatives using 2D rod like bifunctional Fe based MOF and CuO nanocomposites as a novel heterogeneous catalyst
Abstract In this study, a new and efficient Rod-like bifunctional Fe-based MOF@CuO nanocomposites (RL BF Fe-based MOF@CuO NC) were synthesized as new and efficient heterogeneous catalyst through a simple method from easily available 1,3,5-benzenetricarbocylic acid linker, nitrate ferric as a source of iron and copper oxide (CuO) nanoparticles under microwave irradiation. The synthesized nanocatalysts were characterized with different techniques such as Brunauer–Emmett–Teller (BET), energy dispersive spectroscopy (EDS), field emission scanning electron microscopy (FE-SEM), mapping, transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR). The RL BF Fe-based MOF@CuO NC had relatively high specific surface area (203 m2 g−1) while exhibiting superparamagnetic properties. The catalytic activity of RL BF Fe-based MOF@CuO NC was explored in a facile and green methodology to prepare diverse N‑amino-2-pyridones by one-pot four component reactions comprising aromatic aldehyde, malononitrile, methyl cyanoacetate and hydrazine hydrate within mild and solvent-free conditions. This protocol enjoys features like providing the final products during low reaction times in excellent yields under solvent-free conditions. The use of easily available and inexpensive reactants for the synthesis of the catalyst, environmental compatibility, low catalyst loading, fast and clean work-up and reusability of catalyst for several cycles with consistent activity are counted as the outstanding features of this procedure