Efficacy of a combination of imidacloprid 10%/moxidectin 2.5% spot-on (Advocate® for dogs) in the prevention of canine spirocercosis (Spirocerca lupi)

The nematode Spirocerca lupi is a major canine parasite in warm regions of the world, classically causing parasitic nodules in the esophagus, aortic aneurysms, and spondylitis. This study evaluated the preventive efficacy of monthly treatment with imidacloprid 10%/moxidectin 2.5% spot-on (Advocate® for dogs) administered over a period of 9 months in young dogs naturally exposed to S. lupi on Réunion island. One hundred and twelve puppies, aged from 2.0 to 4.0 months and with a negative spirocerca fecal examination at inclusion, completed the study. They were randomly allocated to two groups. Group A puppies (n = 58) received nine spot-on treatments with Advocate® at the minimum dose of 2.5 mg moxidectin/kg bw at monthly intervals. Control group B puppies (n = 54) received no treatment for S. lupi. During the study, regular clinical and fecal examinations were performed, as was final upper gastrointestinal endoscopy. Endoscopy showed that 19 dogs from group B had spirocerca nodules, corresponding to a prevalence of 35.2% in dogs aged 12 to 14 months. In contrast, only one dog from group A had a nodule, corresponding to a preventive efficacy of 94.7% (p < 0.0001). None of the 378 fecal examinations were positive for spirocerca. This study confirms a high prevalence of canine spirocercosis on Réunion and shows that infestation occurs in very young puppies. Furthermore, it demonstrates that monthly spot-on administration of a combination of imidacloprid 10%/moxidectin 2.5% (Advocate® for dogs) in puppies starting at the age of 2 to 4 months achieves effective and safe prevention of canine spirocercosis

EVALUATION A UN AN D'UNE METHODE DE SEVRAGE TABAGIQUE EN GROUPE (PLAN DE CINQ JOURS)

ST ETIENNE-BU Médecine (422182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Une méthode d'éléments finis à décomposition L2 d'ordre élevé motivée par la simulation des écoulements diphasiques bas Mach

PARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF

Présentation du procès pour viol fait à Jehan Waulthier dans la prévôté de Châtenois en 1552

« De rechef la reprint par le bras disant que : Par la mort et vertu Dieu ! il l’en mèneroit ou il tueroit elle, son maître et sa maistresse ; et de faict l’en menist par force contre son gré et volunté […] et estant au delà du mulin […] luy dict : Entre en ceste haye ! […] Mort Dieu, entre ! poussant par force la mist en ladite haye et estant en icelle luy dict : Couche toy ! ce qu’elle ne voulust faire ; ce néantmoins […] par force la couchist par terre et combien que de son pouvoir se deff..

An object-oriented approach to the design of fluid mechanics software

This article presents the guiding principles of the architecture of Trio_U, a new generation of software for thermohydraulic calculations. Trio_U is designed to serve as a thermohydraulic development platform. Its basic conception is object-oriented and it is written in C++. The article demonstrates how this type of design enables an open, modular software architecture

Legged Robots in the Agricultural Context:Analysing Their Traverse Capabilities and Performance

Mobile robots are widely used in agriculture, either as the form of intelligent vehicles or as monitoring platforms, where sensors are placed for the gathering of data. Overall, wheeled robots have play a crucial role in the development of new monitoring techniques, mainly due to their capabilities (their movements can resemble the ones of a tractor) or because of the wide variety found on the market. Nevertheless, another kind of mobile robots, known as legged robots, have not been explored yet in the agricultural context, specifically as platforms for data gathering and eventually, for interaction with the growing. In this work, we compare the capabilities of a legged robot against a wheeled one following previously published guidelines for performance evaluation of both kind of robots. In particular, we evaluate the odometry responses and the energy consumption of the robots when performing previously known manoeuvres. Moreover, considering that in the agricultural context is feasible to find different kind of terrains, we performed our evaluation under grass, gravel and pavement, both even and uneven terrains, for a circle-shaped, closed S-shaped and square-shaped, of different sizes. Overall, the legged robot showed a more uniform response in the power consumption behaviour despite the kind of terrain, but the wheeled robot showed better results from a localization perspective. The analysis provided herein serve as the basis for future usage of legged robots in the agricultural context.</p

Durability of ceramic fibers in the human lung. Preliminary results

International audienceA proper understanding of the pulmonary toxicology of man-made mineral fibres (MMMF) requires information on their durability in the human lung but to date there is little information on this subject. Recently however, we have had the opportunity to document some interesting aspects of the short-term durability of ceramic fibres in human lung by analysing fibres recovered in broncho-alveolar lavage fluid obtained frorn seven men currently employed in the MMMF production industry. Fibres recovered from the lungs by lavage were characterized by analytical transmission electron microscopy. Both normal and highiy-transfonned ceramic fibres were detected. The transformed fibres exhibited a spectrum ofmorphological features and elemental compositions. Some retained a typical ceramic chemistry but were heavily coated with ironcontaining material. Others had a hollow tube morphology, made up offine iron-containing granules without any of the normal major ceramic elements. Such fibres were sometimes found lying under a bed ofsiliceous Seachate. It is hypothesized (hat the transformation process first involves a coating of the ceramic fibres with iron-containing granules, followed by a progressive dissolution of the structural elements. We conclude that some ceraraic fibres are not durable in the human lung