Coarsening dynamics of slipping droplets

The late-phase dewetting process of nanoscopic thin polymer films on hydrophobized substrates using some recently derived lubrication models that take account of large slippage at the polymer-substrate interface is studied. The late phase of this process is characterized by the slow-time coarsening dynamics of arrays of droplets that remain after rupture and the initial dewetting phases. For this situation a reduced system of ordinary differential equations is derived from the lubrication model for large slippage using asymptotic analysis. This extends known results for the no-slip case. On the basis of the reduced model, the role of the slippage as a control parameter for droplet migration is analysed and several new qualitative effects for the coarsening process are identified

The proteasome system in health and disease.

The proteasome is involved in the regulation of all cellular pathways and consequently plays a central role in the control of cellular homeostasis. Together with its regulators, it is at the frontline, both as an actor and as a target, in human health and when homeostasis is disturbed in disease. In this review, we aim to provide an overview of the many levels at which the functions of the proteasome and its regulators can be regulated to cope with cellular needs or are altered in pathological conditions