2 research outputs found
Left ventricular systolic and diastolic function, and exercise capacity six to eight weeks after acute myocardial infarction
Synthesis of novel Bi-, Tri-, and tetracyclic nucleosides by reaction of a common cyclic enamine derived from TSAO-T with nucleophiles
We report here the efficient regio-and stereoselective synthesis of new polycyclic nucleosides using
a common cyclic enamine (7) as the starting material. In fact, the reaction of 7, easily prepared by
reaction of 5¢-O-Tosyl TSAO-T under basic nonnucleophilic conditions (potassium carbonate), with
different classes of nucleophiles, for example, nitrogen-, oxygen-, sulfur-, and carbon-based
nucleophiles, or with amino acids afforded, with total regio-and stereoselectivity, new bi-, tri-, and
tetracyclic nucleosides. This straighforward route represents an original and unambiguously regio-
and stereoselective pathway to these compounds. Some of these polycyclic nucleosides may be useful
intermediates for a second series of reactions that may lead to the generation of structurally new
nucleosides.We thank Susana Ruiz and
Marı´a Jose´ Galeote for their excellent technical as-
sistance. We thank the Ministry of Education of Spain
for grants to C.C. and M.-C.B. The Spanish Ministerio
de Ciencia y Tecnologı´a (Project SAF2003-07219-C02-
01) and the European Commission (Projects QLK2-CT-
2000-00291 and HPAW-CT-2002-90001) are acknowl-
edged for their financial support.Peer reviewe