Dispositif non-destructif d'échantillon pour extraction de marqueur

publication date: 2019-03-14; filing date: 2018-05-19Method and device for extraction of markers, comprising: introducing a sample into a removable support basket placed in the housing of a cell of an extraction device provided with a flexible membrane and immersing the tissue sample in a liquid previously introduced into the housing, followed by hermetic closing of the extraction cell and application of a pressure cycle on the flexible membrane for a period of 1 to 5 minutes at a frequency between 1 and 2 Hz. Then, total or partial recovery of the liquid immersing the sample after the pressure cycle and detection of the markers present in the liquid.Méthode et dispositif d'extraction de marqueurs comprenant, l'introduction d'un échantillon dans un panier-support amovible placé dans le logement d'une cellule d'un dispositif d'extraction muni d'une membrane flexible et immersion de l'échantillon de tissu dans un liquide préalablement introduit dans le logement, suivie de la fermeture hermétique de la cellule d'extraction et application d'un cycle de pression sur la membrane flexible pendant une durée de 1 à 5 minutes, à une fréquence comprise entre 1 à 2 Hz. Ensuite récupération total ou partielle du liquide immergeant l'échantillon après le cycle de pression et détection des marqueurs présents dans le liquide

A highly selective MEMS transducer for hydrogen sensing based on stress modification in palladium thin films

We developed and integrated a MEMS capacitive transducer based on aluminium/palladium bimorph configured as clamped-clamped beams, performing fast and highly selective hydrogen detection. The bimorph is obtained by combining evaporation and sputtering deposition techniques and acts as actuator of the structure. The stress control in the beams has been investigated in order to gain control over the sensing dynamics. The transducer response time is less than 4 s at 0.2 % vol. H2/N2 concentration. The related kinetic shows good correlations to previous in situ experiments of stress modifications in palladium thin films with controlled initial stress. The device is interfaced by an AD774x capacitance-to-digital converter and a CC253x microcontroller within a dedicated housing including a Porex® microporous polymer membrane for IP66 compatibility. Finally, the ultra-low power consumption (< 10 μW) of such devices is very promising to ease their integration in emerging interconnected sensor nodes within the Internet-of-Things vision

Live demonstration: Microsystem integration of a palladium-based MEMS hydrogen gas sensor

In this live demonstration, we present the microsystem integration of a palladium-based MEMS capacitive hydrogen gas sensor and its sub-components. The system includes all the elements of the data acquisition chain. The MEMS device is interfaced by a capacitance-to-digital converter for signal conditioning, and a microcontroller associated to a radio for both data processing and transmitting. Moreover a specific housing has been designed with trade consideration, including a Porex® microporous polymer membrane for moisture protection. Finally, a dedicated graphic user interface has been implemented with assisted calibration or recording procedures, and an oscilloscope for data monitoring. Thanks to compatibilities with ZigBee or Bluetooth low energy protocols, this system is directly dedicated to interconnected sensor nodes applications within the Internet-of-Things vision

Design, fabrication and integration of a palladium-based ultra-low power MEMS hydrogen sensor

We designed, fabricated and integrated an ultra-low power MEMS hydrogen (H2) sensor performing high dynamics together with high sensitivity up to the Lower Explosive Limit (LEL), i.e. 4 % vol. H2 in dry air. The architecture consists of Al clamped-clamped beams (700 nm-thick, 800 μm-total width, 140 or 240 μm-length) with both ends made of a Pd/Al bimorph (200/700 nm-thick) on a quarter of its length, acting as actuators, released above a split-bottom electrode. The initial stress defines the initial deflection of the structure while the Pd-hydriding induces compressive stress variation in the Pd actuator layer and therefore the membrane deflection. A capacitive transduction is used to continuously measure the gap variation due to the H2 absorption and hydriding kinetic. Results show a fast response time of less than 5 s for an effective concentration of about 0.2 % vol. H2 in dry air or N2 mixture, with no cross sensitivity. The MEMS transducer has been encapsulated in a TO-5 package and interfaced with an AD774x capacitance-to-digital converter. The full sensing system, including a CC253x microcontroller, is finally placed in a 4-Series housing, with a POREX® microporous membrane as humidity and small particles filter

Performance of Solmacs, a High PV Solar Concentrator With Efficient Optics

peer reviewedA new solar panel with high concentration photovoltaic technology (x700) has been designed, prototyped and tested in the SOLMACS project. The quality of concentrating optics is a key factor for high module efficiency. Therefore new dedicated PMMA Fresnel lenses were studied and produced by injection molding. Lens design, material and production process were optimized to achieve a high optical yield of 86%. Thorough lens performance assessment in optical laboratory was completed with lifetime UV aging tests. Another important aspect is the thermal control of the hot spot created under the solar cell that receives the concentrated flux of 700 Suns. A dedicated heat spreader was developed to achieve passive thermal control with minimum mass and cost. This was supported by thermal models and tests at both cell and module level. 35% triple junction cells were implemented in the module. Micro-assembly technologies were used for the cell packaging and electrical connections. In support to the research, a continuous solar simulator was designed and built to assess the system performance, both at component and module level. The concentrator developments were integrated in a prototype and tested both indoor with the simulator and outdoor on the CSL solar test platform. The overall efficiency of the PV concentrator module is 28.5%

Composite polymeric-inorganic waveguide fabricated by injection molding for biosensing applications

Inorganic based optical transducers have demonstrated their suitability for labelled and label-free sensing of biomolecules but suffer from their relatively high cost. Photonic structures fabricated in polymer by molding techniques could drastically reduce the cost per test and pave the way for label-free screening in point-of care environment where the cost per test is an essential concern. In this paper we present the advances in the fabrication of waveguides with cyclo olefin copolymer (COC) cladding and TiO2 core with mass-production compatible injection molding and evaporation. We demonstrate the optical propagation in a slab waveguide supporting both transverse electric and magnetic modes and monitor the response of the phase difference between the two modes when a droplet of water is deposited on the chip