9 research outputs found
Osteoid osteoma of the ethmoid bone associated with dacryocystitis
BACKGROUND: Osteoid osteomas (OO) are small, benign osteoblastic lesions. Ethmoid bone OO has been very rarely reported so far. CASE PRESENTATION: We report a case of a 16-year-old boy suffering from persistent epiphora and a mild pain in the area of median canthus, due to a bone density mass within the right ethmoid air cells extending to the ipsilateral right orbit. The mass was removed via an external ethmoidectomy approach. Histopathologic examination of the specimen set the diagnosis of OO. One year after the operation the patient is free of symptoms, while no recurrence occurred. CONCLUSION: A case of ethmoid bone OO associated with dacryocystitis is reported. Although benign and rare, OO should be considered in differential diagnosis of the ethmoid bone osteoblastic lesions
Antihistamine effects on experimental middle ear inflammatory model
Allergy is thought to be one of the etiologic factors in otitis media.
The purpose of this study was to determine the histopathologic effects
of H1 histamine receptor antagonists in an experimental
histamine-induced middle ear inflammation model. In group A (20
rabbits), histamine challenge followed a 3-day intramuscular
pretreatment with a single dose of 0.1 ml hydroxyzine hydrochloride (50
mg/ml) per day. In group B (20 rabbits), histamine challenge followed a
3-day pretreatment with a single dose 1.2 mg desloratadine per day
orally. In group C (20 rabbits), histamine challenge followed a 3-day
pretreatment with a single dose 1.2 mg levocetirizine per day orally. On
the fourth day after baseline otomicroscopy 0.5 ml histamine 20 mg/ml
was injected transtympanically on the right. Middle ear mucosa was
removed and the following parameters were assessed: edema, vascular
dilatation and congestion, inflammation, acute inflammatory component,
presence of eosinophils, activity of the inflammation and fibrosis. A
semi-quantitative grading system of 0-3 was used for grading of all
parameters and statistical analysis performed by using the Mann-Whitney
non-parametric test. Group A mucosae showed lower grades of all the
parameters evaluated compared with those of group B. Histopathology of
the mucosae of group C showed lower grade of inflammation compared with
group B with significant statistical difference for the seven parameters
tested. Our data validate the use of antihistamines in the treatment of
refractory OME of allergic origin. Oldest H1 antagonists can be replaced
by the newest agents who counteract successfully histamine effects,
without any interactions or adverse effects from central nervous system