How Well Do Patent Citations Measure Flows of Technology? Evidence from French Innovation Surveys

Patent citation data are used in a growing body of economics and business research on technological diffusion. Research in this area uses “backward” citations to measure technological knowledge acquired by the patenting entities studied. “Forward” citations (citations to the firm’s patents made by other patents) have been interpreted as a measure of the knowledge diffusing outward from the patenting entity. Until now, there exists little evidence on whether or not patent citations are a good measure of knowledge flows. Our paper assesses the legitimacy of using European patent citations as a measure of technology flows. It uses information from the Community Innovation Survey (CIS) collected by the French Service des Statistiques Industrielles (SESSI), which contain firms’ responses to questions about their innovative activity. We show that patent citations are indeed related to firms’ statements about their acquisition and dispersion of new technology, but that the strength and statistical significance of this relationship varies across geographical regions and across channels of knowledge diffusion.patent, citation, Community Innovation Survey, innovation, spillovers, count data

A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters

Molecular farming of vaccines has been heralded as a cheap, safe and scalable production platform. In reality, however, differences in the plant biosynthetic machinery, compared to mammalian cells, can complicate the production of viral glycoproteins. Remodelling the secretory pathway presents an opportunity to support key post-translational modifications, and to tailor aspects of glycosylation and glycosylation-directed folding. In this study, we applied an integrated host and glyco-engineering approach, NXS/T Generation™, to produce a SARS-CoV-2 prefusion spike trimer in Nicotiana benthamiana as a model antigen from an emerging virus. The size exclusion-purified protein exhibited a characteristic prefusion structure when viewed by transmission electron microscopy, and this was indistinguishable from the equivalent mammalian cell-produced antigen

Friday Convocation

Program listing performers and works performe

Escaping “Perpetual Beginnings”: Challenges and Opportunities for Local Atrocity Prevention in the Democratic Republic of Congo

This report is part of a three-year (2019-2022) project “Strengthening Networks to Prevent and Respond to Violence”, funded through a UK government (previously DFID) funded Jo Cox Memorial Grant, and led by Peace Direct in partnership with Protection Approaches, Beni Peace Forum (BPF), Réseau des organisations des Jeunes en Action pour la paix, la réconciliation et le développement (REJA), and the Armed Conflict Location & Event Data Project (ACLED). The project aims to ensure that local civil society is better able to provide strategic, coordinated and sustainable atrocity prevention work in eastern DRC and Burundi. This research focused on eastern DRC and sought to identify and understand the following: • The status and composition of current atrocity prevention efforts in Ituri, and North and South Kivu, including key actors and means of coordination; • What approaches to atrocity prevention are considered most effective by local, national and international actors; • The primary challenges faced by local, national and international actors engaged in atrocity prevention work; and • The forms of support from regional and international actors that are required to improve current atrocity prevention outcomes. The report is based on interviews and focus group discussions with 169 individuals, including civil society and community members, DRC government actors, local academics, UN staff, INGO staff, foreign donors and foreign government actors involved in atrocity prevention work in eastern DRC, which were carried out between February and June 2020

Executive Summary: Escaping “Perpetual Beginnings”: Challenges and Opportunities for Local Atrocity Prevention in the Democratic Republic of Congo

Executive Summary for the report "Escaping “Perpetual Beginnings”: Challenges and Opportunities for Local Atrocity Prevention in the Democratic Republic of Congo

LSDV-Vectored SARS-CoV-2 S and N Vaccine Protects against Severe Clinical Disease in Hamsters

The SARS-CoV-2 pandemic demonstrated the need for potent and broad-spectrum vaccines. This study reports the development and testing of a lumpy skin disease virus (LSDV)-vectored vaccine against SARS-CoV-2, utilizing stabilized spike and conserved nucleocapsid proteins as antigens to develop robust immunogenicity. Construction of the vaccine (LSDV-SARS2-S,N) was confirmed by polymerase chain reaction (PCR) amplification and sequencing. In vitro characterization confirmed that cells infected with LSDV-SARS2-S,N expressed SARS-CoV-2 spike and nucleocapsid protein. In BALB/c mice, the vaccine elicited high magnitude IFN-γ ELISpot responses (spike: 2808 SFU/106 splenocytes) and neutralizing antibodies (ID50 = 6552). Testing in hamsters, which emulate human COVID-19 disease progression, showed the development of high titers of neutralizing antibodies against the Wuhan and Delta SARS-CoV-2 variants (Wuhan ID50 = 2905; Delta ID50 = 4648). Additionally, hamsters vaccinated with LSDV-SARS2-S,N displayed significantly less weight loss, lung damage, and reduced viral RNA copies following SARS-CoV-2 infection with the Delta variant as compared to controls, demonstrating protection against disease. These data demonstrate that LSDV-vectored vaccines display promise as an effective SARS-CoV-2 vaccine and as a potential vaccine platform for communicable diseases in humans and animals. Further efficacy testing and immune response analysis, particularly in non-human primates, are warranted

Development and first validation of the Refined Alcohol Expectancy Task (RAET).

Addressing limitations of existing self-report measures of alcohol-related thoughts and behaviours, researchers have begun to measure these pictographically. To date, however, these novel measures have been developed somewhat unsystematically and are predicated on a number of potentially problematic assumptions, meaning that researchers have not been able to assess their reliability or validity fully. This report therefore documents the development of a Refined Alcohol Expectancy Task through (1) selection (2) development and (3) testing of stimuli for inclusion of this pictograph-based tasks. It also provides initial validation data. Key findings: • This paper outlines the development and initial validation of a pictorial measure of alcohol-related beliefs, namely the Refined Alcohol Expectancy Task (RAET) • Participants were equally efficient in recognising the alcoholic and non-alcoholic pictures and could identify the emotions in the pictographic representations • The RAET has adequate psychometric properties and successfully assesses alcohol expectancies • Expectancy dimensions assessed by the RAET seemed to be independent of drinking habit

Multi-Messenger Gravitational Wave Searches with Pulsar Timing Arrays: Application to 3C66B Using the NANOGrav 11-year Data Set

When galaxies merge, the supermassive black holes in their centers may form binaries and, during the process of merger, emit low-frequency gravitational radiation in the process. In this paper we consider the galaxy 3C66B, which was used as the target of the first multi-messenger search for gravitational waves. Due to the observed periodicities present in the photometric and astrometric data of the source of the source, it has been theorized to contain a supermassive black hole binary. Its apparent 1.05-year orbital period would place the gravitational wave emission directly in the pulsar timing band. Since the first pulsar timing array study of 3C66B, revised models of the source have been published, and timing array sensitivities and techniques have improved dramatically. With these advances, we further constrain the chirp mass of the potential supermassive black hole binary in 3C66B to less than $(1.65\pm0.02) \times 10^9~{M_\odot}$ using data from the NANOGrav 11-year data set. This upper limit provides a factor of 1.6 improvement over previous limits, and a factor of 4.3 over the first search done. Nevertheless, the most recent orbital model for the source is still consistent with our limit from pulsar timing array data. In addition, we are able to quantify the improvement made by the inclusion of source properties gleaned from electromagnetic data to `blind' pulsar timing array searches. With these methods, it is apparent that it is not necessary to obtain exact a priori knowledge of the period of a binary to gain meaningful astrophysical inferences.Comment: 14 pages, 6 figures. Accepted by Ap