Anti-Pfs25 antibody titer of EPA, TT or CRM conjugates of Pfs25 synthesized by thioether (TE) chemistry formulated in either Alhydrogel (AH) or AdjuPhos (AP).

<p>Immune sera were collected from Day 42 after two vaccinations were analyzed. Dose: 0.5 μg/mouse.</p

Physico-chemical parameters of Pfs25 -EPA conjugates with different molecular weight and particle size used in the mice study evaluating the effect of size on the immunogenicity (Fig 5).

<p>Physico-chemical parameters of Pfs25 -EPA conjugates with different molecular weight and particle size used in the mice study evaluating the effect of size on the immunogenicity (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190312#pone.0190312.g005" target="_blank">Fig 5</a>).</p

Le Courrier

31 mars 18261826/03/31 (A0,N90)

Anti-Pfs25 or Pfs230D1 antibody titer of EPA conjugates of Pfs25 and Pfs230D1 synthesized by thioether (TE) and Amide (Am) conjugation chemistry.

<p>Mice were immunized with conjugates formulated in saline or Alhydrogel. Sera were analyzed on Day 42 after vaccination on Day 0 and 28. Dose: 0.5 μg/mouse.</p

Anti-Pfs25 antibody titer of EPA conjugates of Pfs25 with varying average molecular weight and particle size, synthesized by thioether (TE) chemistry, formulated in either saline or Alhydrogel (AH).

<p>Immune sera collected on Day 42 (left panel) or 70 (right panel) were analyzed by ELISA. Vaccinations on Days 0 and 28. Doses: 0.5 μg or 0.1 μg/mouse/injection as indicated.</p

Physico-chemical parameters of various conjugates of PfCSP, Pfs25 and Pfs230D1 with EPA, TT or CRM197.

<p>Physico-chemical parameters of various conjugates of PfCSP, Pfs25 and Pfs230D1 with EPA, TT or CRM197.</p