4 research outputs found
Assessment of CSF Flow Dynamics Using PC-MRI in Spontaneous Intracranial Hypotension
Aim.-Spontaneous intracranial hypotension (SIH) is caused by spontaneous cerebrospinal fluid (CSF) leaks and is known to cause orthostatic headaches. Phase-contrast magnetic resonance imaging (PC-MRI) is a non-invasive technique that can be used to quantify variation in CSF flow. The aim of this study was to assess CSF flow dynamics using PC-MRI in SIH
In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation
Background: Infertility is a problem concerning 10-15% of the individuals in the fertile period. This study investigated effects of proinflammatory factors as well as lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success
In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation
Background: Infertility is a problem concerning 10-15% of the individuals in the
fertile period. This study investigated effects of proinflammatory factors as well as
lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success.
Materials and Methods: In this prospective, non-randomized, controlled clinical study,
sera obtained from 26 fertile (group-1), 26 infertile women before (group-2) and after
(group-3) IVF treatment were analyzed. Leptin, leptin receptor, resistin, tumor necrosis
factor-alpha (TNF-α), and C-reactive protein (CRP) were analyzed using enzyme-linked
immunosorbent assay (ELISA). LPO was determined spectrophotometrically. Mann-
Whitney U test, paired samples t test, Wilcoxon signed-rank test as well as Pearson correlation
analysis by SPSS were performed for statistical analysis.
Results: TNF-α, resistin and LPO levels increased (P=0.020, P=0.003, P=0.001, respectively)
in group-3 compared to group-2. A significant increase in LPO was noted both in
group-2 and -3 compared to controls (P=0.000). LPO were higher in non-pregnants than
pregnants in group-2. For pregnants, significant correlations were observed between leptin
and resistin in group-2 and TNF-α and leptin in group-3. None of these correlations
were found for the women, who could not conceive.
Conclusion: LPO, leptin-resistin correlation, associations with TNF-α may be helpful
during the interpretation of IVF success rates