MOESM1 of Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study

Supplementary material 1 (DOC 559 kb

Joint effects of saturated fat and fiber intake on iCVD risk, men.

<p>Joint effects of quintiles of energy-adjusted saturated fat and fiber intake on risk of ischemic cardiovascular disease in men of the MDC cohort, expressed as hazard ratios. The numbers given in the figure are those significantly different (<i>p</i><0.05) from the reference category (F5/SFA1). <i>p</i> value for the interaction between fiber and saturated fat = 0.041. Adjusted for age, method version, total energy intake (continuous), season, BMI class, smoking category, education, alcohol category, systolic blood pressure, antihypertensive treatment, antilipemic treatment and leisure time physical activity (quartiles). RR:s calculated with no individual nutrient variables in the model due to redundancy.</p

Hazard ratios (HR) and 95% confidence intervals (CI) for incident cardiovascular (CV) events¹ by adherence to recommended intake of the index components² in men (n = 6940) and women (n = 10 186) of the Malmö Diet and Cancer study (1991–2008).

1<p>Incident CV event was defined as non-fatal or fatal myocardial infarction or ischemic stroke, or death from ischemic heart disease.</p>2<p>Adherence to the index components was dichotomized based on pre-specified recommended intake levels (adherence = 1 and non-adherence = 0) and non-adherence was used as the reference category.</p>*<p>HRs and 95% CIs estimated using a Cox proportional hazards regression model adjusting for dietary assessment method version, age, total energy, and season of data collection.</p>†<p>Additional adjustment for waist circumference, smoking status, leisure-time physical activity, and alcohol consumption.</p>§<p>Multivariate model (as above) with mutual adjustment for the index components in this table.</p

Kaplan-Meier curves of cardiovascular event-free survival by categories of DQI-SNR score among men (n = 6 940) in the Malmö Diet and Cancer cohort (1991–2008).

<p>Analysis time was cut-off at 16 years of follow-up.</p

Risk of total ischemic cardiovascular disease in 12,535 women (687 cases)^a by intake of fat (multivariate hazard ratios with 95% confidence intervals per quintile of energy-adjusted intake).

a<p>12,402 women and 676 cases in the full model due to missing values.</p>b<p>Cases/person years.</p>c<p>Basic model: Adjusted for age, method version, total energy intake (continuous), and season.</p>d<p>Full model: Adjusted for age, method version, total energy intake (continuous), season, BMI class, smoking category, education, alcohol category, systolic blood pressure, antihypertensive treatment, antihyperlipidemic treatment, leisure time physical activity (quartiles) and quintiles of energy-adjusted dietary fiber.</p

Baseline characteristics of men (n = 6940) and women (n = 10186) of the Malmö Diet and Cancer cohort (1991–1996) by categories of total index score¹.

1<p>Total index score ranged from 0 to 6 points based on adherence to six dietary components. Low score was defined as 0–1, medium score as 2–3 and high score as 4–6 points.</p>*<p>ANOVA was used to calculate <i>P</i> values across categories of score for continuous variables and χ²-test to calculate <i>P</i> values for distribution of categorical variables across categories of score.</p

Kaplan-Meier curves of cardiovascular event-free survival by categories of DQI-SNR score among women (n = 10 186) in the Malmö Diet and Cancer cohort (1991–2008).

<p>Analysis time was cut-off at 16 years of follow-up.</p

Distribution of non-alcohol energy percentages from selected nutrients in participants of the Malmö Diet and Cancer cohort with stable dietary habits (medians).

a<p>Expressed as grams per 1000 kcal reported energy intake.</p

Baseline characteristics according to cardiovascular event at follow-up on June 30, 2009.

<p>^aThe difference in baseline characteristics between cases and non-cases was tested with a general linear model adjusted for age and sex.</p><p>^bAll values are expressed as means (95% CI).</p><p>Baseline characteristics according to cardiovascular event at follow-up on June 30, 2009.</p

Selected background characteristics of participants of the Malmö Diet and Cancer cohort with stable dietary habits.

a<p>Numbers by variable: Blood pressure – 8,129 men and 12,514 women; BMI – 8,130 men and 12,525 women; educational level – 8,120 men and 12,509 women; smoking – 8,137 men and 12,532 women; other variables – 8,139 men and 12,535 women.</p