Demographic and clinical characteristics of study populations (N = 594).

1<p>Participants with mania were assessed at time of evaluation during the hospital stay.</p>2<p>Multi-episode schizophrenia, n = 233.</p>3<p>Multi-episode schizophrenia, n = 228; Non-psychiatric controls, n = 205.</p>4<p>RBANS = Repeatable Battery for the Assessment of Neuropsychological Status.</p>5<p>PANSS = Positive and Negative Syndrome Scale.</p>6<p>YMRS = Young Mania Rating Scale.</p>7<p>Ham-D = Hamilton Rating Scale for Depression.</p

Psychiatric medications received by study participants.

1<p>Medications were recorded for the mania group at time of evaluation during the hospital stay. For all other groups, the medications are those received at the time of the one study visit.</p

The association between packs per day (ppd) smoked and antibodies to Epstein Barr Virus nuclear antigen (EBV NA), virion (EBV virion), and anti-viral capsid antigen (EBV VCA) from linear regression models employing age, sex, race, and psychiatric diagnosis as covariates.

(CMV- F(9, 1299) = 28.01, R2 = 0.1314, VIF = 1.28; EBV NA - F(9, 1299) = 16.97, R2 = 0.1052. VIF = 1.28; EBV Virion – F (9,1269) = 31.71, R2 = 0.1836, VIF = 1.28; EBV VCA F(9,1280) = 29.82, R2 = 0.1733, VIF = 1.28).</p

The association between cigarette smoking and quantitative levels of antibodies to Cytomegalovirus (CMV); Epstein Barr Virus nuclear antigen (EBV NA), virion (EBV virion), and anti-viral capsid antigen (EBV VCA); Herpes Simplex Virus Type 1 (HSV-1); Varicella Zoster Virus (VZV); and Human Herpes Virus 6 (HHV-6) from linear regression models employing age, sex, race, and psychiatric diagnosis as covariates; ** = p<.01, *** p<.001).

N = 1323 except for HHV-6, N = 1206. (CMV- F(7, 1315) = 28.01, R2 = 0,1298, VIF = 1.32; EBV NA - F(7, 1315) = 21,82, R2 = 0,1041, VIF = 1.32; EBV Virion – F (7,1284) = 40.59, R2 = 0.1812, VIF = 1.32; EBV VCA F(7,1296) = 37.96, R2 = 0.1701, VIF = 1.32; HSV-1- F(7, 1315) = 11.35, R2 = 0.0570, VIF = 1.32; VZV – F(7, 1300) = 5.04, R2 = 0.0264, VIF = 1.31); HHV-6 – F(7,1198), R = 0.0182, VIF = 1.29).</p

Cigarette smoking status and packs per day smoked by diagnostic group.

Cigarette smoking status and packs per day smoked by diagnostic group.</p

Antibody measurements.

(DOCX)</p

Association between CMV IgG Antibody Levels and Cognitive Scores (N = 521).

1<p>Adjusted for age, gender, race, maternal education, and participant education.</p>2<p>RBANS =  Repeatable Battery for the Assessment of Neuropsychological Status; total score and index scores.</p>3<p>Letter Number Sequencing, scale score.</p>4<p>WCST =  Wisconsin Card Sorting Test.</p>5<p>Trail Making Test, part A, scale score.</p

Minimal dataset for study.

(XLS)</p

Characteristics of study participants¹.

Characteristics of study participants1.</p

Marginal effects (mean +/- 95% confidence intervals of the indicated EBV antibody by number of cigarettes smoked per day adjusted for age, gender, race, and diagnostic group.

Marginal effects (mean +/- 95% confidence intervals of the indicated EBV antibody by number of cigarettes smoked per day adjusted for age, gender, race, and diagnostic group.</p