The Role of the Acquisitions Editor in University Press Publishing

This study examines the changing role of acquisitions editors within university presses. The various factors that contribute to the changing role of acquisitions editors were examined through personal interviews of twenty-nine acquisitions editors from university presses across the United States. Twenty questions were presented to the editors on editorial responsibilities, book marketing, electronic publishing, education and job training, and author/editor relationships. This study concentrated on those questions, as well as on the evolving role of acquisitions editors when affected by variables such as library acquisitions, financial trends, electronic publishing, and rules for professorial tenure that affect changes in scholarly publishing. The study concluded that acquisitions editors still gain most of their training through job experience, although many more outlets exist now for education than were offered twenty years ago. The editors indicated that business and financial training would be helpful because of the constraints placed on scholarly publishing due to decreased university subsidies and declining sales to libraries. When acquiring manuscripts, editors use a network of scholars and authors who serve as expert advisers when evaluating scholarship in particular fields. The scholarship acquired by acquisitions editors should support the press’ mission to publish the best research available. Acquisitions editors must consider the manuscript’s potential sales, implying its appeal to the broadest possible audience, when deciding whether to publish, thus affecting the types of manuscripts they acquire. In order to recover revenue lost in publishing traditional, narrowly focused monographs and from a decrease in university subsidy, editors must balance their lists with monographs that reach the broadcast possible audience of scholars and with trade books that will reach a general audience. Most editors compete with other university presses for the most desirable scholarship by allowing multiple submissions from senior scholars and from those facing a tenure deadline. The editors acknowledge that electronic publishing may become a foundation of scholarly publishing in the future; however, currently there is not a high demand for electronic books, nor is there an established system to regulate the purchase of a book placed on the Internet. Some presses are experimenting with various electronic procedures, while others are waiting for the question to be resolved

Trajectories of perinatal depressive symptoms in South Africa

Perinatal depression, which occurs during pregnancy and within one year postpartum, is highly prevalent in South Africa. It is associated with greater risk of birth complications, poorer health outcomes and greater risk of suicide behaviours for the mother. Perinatal depression is also associated with poorer physical, cognitive, socio-emotional and behavioural development for her child. There is preliminary evidence using growth curve mixture modelling (GCMM) that the course of perinatal depression is heterogeneous, and that each course is associated with a range of risk factors and child outcomes. Most of this evidence is generated in high-income countries (HICs), however. Little is known about the course of perinatal depression in low-income settings, where women are more likely to experience social and economic adversity, and where the patterns of risk among mothers and their children are likely to differ. The overall aim of this thesis was to identify the trajectories of perinatal depressive symptoms among low-income women in South Africa, and investigate whether these were associated with specific psychosocial and economic risk factors, child outcomes and suicidal risk over time. First, the available literature on the use of GCMM to identify trajectories of perinatal depressive symptoms is systematically reviewed. Evidence, all from HICs, suggests that there are heterogenous trajectories. The most commonly reported trajectories are (i) a ‘low-risk’ trajectory, characterised by chronically low levels of depressive symptoms throughout the perinatal period, (ii) a ‘high-risk’ trajectory, characterised by chronically severe levels of depressive symptoms, and (iii) an ‘antenatal’ trajectory, with greater levels of symptoms antenatally, which naturally abate before or just after birth. How women with different trajectories differ in terms of social, economic and health-related characteristics was inconsistent. Data from two randomised controlled trials (RCTs) were then utilised to investigate the trajectories of depressive symptoms among perinatal women living in a low-income setting in South Africa. Both RCTs were conducted in Khayelitsha, a peri-urban township settlement close to Cape Town, characterised by high levels of poverty and unemployment, and high crime rates. The RCTs were the Africa Focus on Intervention Research for Mental Health, and the Philani Intervention Programme. The former was conducted among perinatal women at risk for depression during pregnancy, while the latter was conducted among all perinatal women, regardless of the severity of their depressive symptom at recruitment. No differences were found in depressive symptoms between the control and intervention arms in either RCT, so both arms were combined, where appropriate. The trajectories of perinatal depressive symptoms, identified though growth mixture modelling or latent class growth analysis, were similar to those reported in the systematic review. A high-risk trajectory was identified in both samples; it was characterised by greater socio-economic and health-related risks, including alcohol use during pregnancy and lower levels of social support, factors which differentiated women allocated to this trajectory from women who had low symptom levels or who showed a natural remission pattern over the perinatal period. Children of mothers with chronically severe depressive symptoms reported greater emotional problems at 36 months postpartum. Children of mothers who reported more severe depressive symptoms either early or later in the postpartum period also showed poorer physical growth at 18 and 36 months. Finally, a series of generalised estimating equations indicated that change in depressive symptoms among women initially at risk for depression during pregnancy was associated with change in the severity of suicidal risk during the perinatal period, but only when depressive symptoms decreased, and that among younger women and those who showed a lower risk trajectory of depressive symptoms. Relatively similar trajectories of perinatal depressive symptoms were identified among perinatal women in Khayelitsha, compared to studies in HICs. Women presented with different trajectories of depressive symptoms over the perinatal period, each with specific sets of risk factors and distinct associations with severity of suicidal risk and child outcomes over time. Depression and suicidal risk should be assessed independently from one another throughout the perinatal period. The consistently identified high-risk trajectory highlights the need to integrate health, social and economic characteristics into the identification and prevention strategies for perinatal depression. Given the limited mental health resources available at primary care level in South Africa, this thesis contributes to developing efficient methods to identify, refer and manage women who may need more intensive mental health care

Development of a bioavailability‐based risk assessment approach for nickel in freshwater sediments

To assess nickel (Ni) toxicity and behavior in freshwater sediments, a large‐scale laboratory and field sediment testing program was conducted. The program used an integrative testing strategy to generate scientifically based threshold values for Ni in sediments and to develop integrated equilibrium partitioning‐based bioavailability models for assessing risks of Ni to benthic ecosystems. The sediment testing program was a multi‐institutional collaboration that involved extensive laboratory testing, field validation of laboratory findings, characterization of Ni behavior in natural and laboratory conditions, and examination of solid phase Ni speciation in sediments. The laboratory testing initiative was conducted in 3 phases to satisfy the following objectives: 1) evaluate various methods for spiking sediments with Ni to optimize the relevance of sediment Ni exposures; 2) generate reliable ecotoxicity data by conducting standardized chronic ecotoxicity tests using 9 benthic species in sediments with low and high Ni binding capacity; and, 3) examine sediment bioavailability relationships by conducting chronic ecotoxicity testing in sediments that showed broad ranges of acid volatile sulfides, organic C, and Fe. A subset of 6 Ni‐spiked sediments was deployed in the field to examine benthic colonization and community effects. The sediment testing program yielded a broad, high quality data set that was used to develop a Species Sensitivity Distribution for benthic organisms in various sediment types, a reasonable worst case predicted no‐effect concentration for Ni in sediment (PNECsediment), and predictive models for bioavailability and toxicity of Ni in freshwater sediments. A bioavailability‐based approach was developed using the ecotoxicity data and bioavailability models generated through the research program. The tiered approach can be used to fulfill the outstanding obligations under the European Union (EU) Existing Substances Risk Assessment, EU Registration, Evaluation, Authorisation, and Regulation of Chemicals (REACH), and other global regulatory initiatives. Integr Environ Assess Manag 2016;12:735–746. © 2015 SETACKey PointsA comprehensive, representative sediment toxicity database is available to support risk assessment of Ni in freshwater sediments.Sediment Ni ecotoxicity data were gathered from studies that used spiking approaches that resulted in Ni‐enriched sediments resembling naturally contaminated sediments, thus increasing their relevance.Bioavailability of Ni in sediments, which is controlled by acid volatile sulfides (AVS), varies among different species, with actively bioturbating species showing a lower slope in the relationship between decreasing toxicity with increasing AVS.A bioavailability‐based, tiered approach is presented, where the first tier involves comparison of ambient total Ni concentrations with a RWC threshold value of 136 mg Ni/kg. Site‐specific AVS can be used to calculate a site‐specific threshold if ambient Ni is greater than 136 mg Ni/kg.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134197/1/ieam1720.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134197/2/ieam1720_am.pd

Perinatal depressive symptoms among low-income South African women at risk of depression: trajectories and predictors

Abstract Background The aim of the study was to identify trajectories of perinatal depressive symptoms and their predictors among women living in a low-resource setting in South Africa, and who present with a risk of depression during pregnancy. Methods This is a secondary analysis of a randomised controlled trial among 384 women living in Khayelitsha, a low income setting in South Africa, recruited at their first antenatal visit if they scored 13 or above on the Edinburgh Postnatal Depression Scale, were at least 18 years of age, less than 29 weeks pregnant and spoke isiXhosa. Participants were followed up at 8 months gestation, 3 and 12 months postpartum. Latent trajectories of depressive symptoms were identified using growth mixture modelling, based on the Hamilton Depression Rating Scale (HDRS). There were no differences in HDRS scores between the control and intervention arms, so all participants were assessed together. Health, social and economic predictors of trajectories were investigated to identify high-risk groups with greater or more chronic depressive symptoms, using univariate logistic regression. Results Two trajectories were identified: antenatal only (91.4%), with moderate to severe symptoms at baseline which later subside; and antenatal and postnatal (8.6%), with severe depressive symptoms during pregnancy and later in the postpartum period, which subside temporarily to moderate levels at 3 months postpartum. Predictors for the antenatal and postnatal trajectory include severe food insecurity, intimate partner violence, lower social support, greater functional impairment, problematic drinking and suicide risk. Conclusions A small proportion of women who are at risk for depression antenatally remain at risk throughout the perinatal period, and can be differentiated from those who show a natural remission. Identification and referral strategies should be developed with these findings in mind, especially given the limited mental health resources in low-income settings

Group problem solving therapy for perinatal depression in primary health care settings in rural Uganda:an intervention cohort study

Background: Perinatal depression is of substantial public health importance in low and middle income countries. The study aimed to evaluate the impact of a mental health intervention delivered by non-specialist health workers on symptom severity and disability in women with perinatal depression in Uganda. Methods: Pregnant women in the second and third trimester were consecutively screened using the Luganda version of the 9-item Patient Health Questionnaire (PHQ-9). Women who scored ≥5 on the PHQ-9 and who were confirmed to have depression by a midwife were recruited into a treatment cohort and offered a psychological intervention in a stepped care fashion. Women were assessed with PHQ-9 and WHODAS-2.0 at baseline and again at 3 and 6 months after the intervention. Negative regression analysis was done to examine change in PHQ-9 and WHODAS-2.0 scores from baseline to end line. Data were analysed using STATA version 14. Results: A total of 2652 pregnant women (98.3%) consented to participate in the study and 153 (5.8%) were diagnosed as depressed. Over a quarter (28.8%) reported having experienced physical interpersonal violence (IPV) while (25.5%) reported sexual IPV in the past year. A third (34.7%) of women diagnosed with depression received 4 or more group PST sessions. There was a mean reduction in PHQ-9 score of 5.13 (95%CI − 6.79 to − 3.47, p &lt; 0.001) and 7.13 (95%CI − 8.68 to − 5.59, p &lt; 0.001) at midline and endline, respectively. WHODAS scores reduced significantly by − 11.78 points (CI 17.64 to − 5.92, p &lt; 0.001) at midline and − 22.92 points (CI 17.64 to − 5.92, p &lt; 0.001) at endline. Clinical response was noted among 69.1% (95%CI 60.4–76.6%) and 93.7% (95%CI 87.8–96.8%) of respondents at midline and endline, respectively. Conclusion: An evidence based psychological intervention implemented in primary antenatal care by trained and supervised midwives in a real-world setting may lead to improved outcomes for women with perinatal depression. Future randomised studies are needed to confirm the efficacy of this intervention and possibility for scale up.</p

Group problem solving therapy for perinatal depression in primary health care settings in rural Uganda:an intervention cohort study

Background: Perinatal depression is of substantial public health importance in low and middle income countries. The study aimed to evaluate the impact of a mental health intervention delivered by non-specialist health workers on symptom severity and disability in women with perinatal depression in Uganda. Methods: Pregnant women in the second and third trimester were consecutively screened using the Luganda version of the 9-item Patient Health Questionnaire (PHQ-9). Women who scored ≥5 on the PHQ-9 and who were confirmed to have depression by a midwife were recruited into a treatment cohort and offered a psychological intervention in a stepped care fashion. Women were assessed with PHQ-9 and WHODAS-2.0 at baseline and again at 3 and 6 months after the intervention. Negative regression analysis was done to examine change in PHQ-9 and WHODAS-2.0 scores from baseline to end line. Data were analysed using STATA version 14. Results: A total of 2652 pregnant women (98.3%) consented to participate in the study and 153 (5.8%) were diagnosed as depressed. Over a quarter (28.8%) reported having experienced physical interpersonal violence (IPV) while (25.5%) reported sexual IPV in the past year. A third (34.7%) of women diagnosed with depression received 4 or more group PST sessions. There was a mean reduction in PHQ-9 score of 5.13 (95%CI − 6.79 to − 3.47, p &lt; 0.001) and 7.13 (95%CI − 8.68 to − 5.59, p &lt; 0.001) at midline and endline, respectively. WHODAS scores reduced significantly by − 11.78 points (CI 17.64 to − 5.92, p &lt; 0.001) at midline and − 22.92 points (CI 17.64 to − 5.92, p &lt; 0.001) at endline. Clinical response was noted among 69.1% (95%CI 60.4–76.6%) and 93.7% (95%CI 87.8–96.8%) of respondents at midline and endline, respectively. Conclusion: An evidence based psychological intervention implemented in primary antenatal care by trained and supervised midwives in a real-world setting may lead to improved outcomes for women with perinatal depression. Future randomised studies are needed to confirm the efficacy of this intervention and possibility for scale up

Evaluating the role of levels of exposure to a task shared depression counselling intervention led by behavioural health counsellors: outcome and process evaluation

Background In the context of a large treatment gap for common mental disorders (CMDs) and shortage of mental health specialists in low- and middle-income countries, there is increasing evidence of the effectiveness of task sharing of counselling interventions to increase access to mental health care for CMDs at primary health care level. This study evaluated the relationship between levels of exposure to a task-shared counselling intervention and psychosocial outcomes (depression, functional disability, internalised stigma and social support) in chronic care service users with comorbid depression in South Africa guided by the Medical Research Council process evaluation framework. Implementation and participant-level factors that promote greater exposure were also investigated. Method The study design was a cohort study comprising of 173 participants referred by primary health care nurses for the task-shared counselling intervention. The study site comprised four primary health care facilities in a sub-district of the Dr. Kenneth Kaunda district in the North West Province of South Africa. The participants were assessed for psychosocial outcomes at three time points: baseline, 3 months and at 12 months. The number of counselling sessions each participant was exposed to was collected for each participant. Linear regression models were used to test the influence of counselling exposure on each of the psychosocial variables between baseline and endline. In-depth qualitative interviews were conducted on 29 randomly selected participants, stratified according to exposure to counselling sessions, and analysed using framework analysis. Findings Findings from the cohort study indicated a significant reduction in depression severity at 12 months. Internalised stigma and functional disability improved from baseline to endline. Participants receiving 5–8 sessions have the greatest reduction in PHQ9 scores from baseline to endline (β = − 2.46, 95% CI − 5.06 to 0.15) compared to those with 0 sessions (β = − 0.51, 95% CI − 3.62 to 2.60, p = 0.064). The WHODAS scores decreased significantly more from baseline to endline among those who received 5–8 sessions (β = − 10.73, 95% CI − 19.86 to 1.59) compared to those with 0 sessions (β = 2.25, 95% CI − 8.65 to 13.14, p = 0.021). No significant differences as a function of levels of counselling exposure from baseline to endline was observed for OSS-3 scores. An improvement in ISMI scores from 1–4 sessions to 5–8 sessions was found (β = − 4.05, 95% CI − 7.30 to − 0.80, p = 0.015). The qualitative process evaluation indicated that the service was acceptable and accessible; but that session attendance was hindered by women’s’ caregiving burden, poor counsellor attributes and poor referral processes. Conclusion Exposure to a greater number of sessions (5–8 sessions) was found to optimize functional ability, reduce stigma, and potentially reduce depression symptoms. In order to enhance session attendance, lay counsellor delivered psychosocial interventions need to pay attention to (i) counsellor selection criteria, particularly person-centred care qualities; and (ii) strengthening referral processes in contexts where mental health literacy is low

Khayelitsha, South Africa: Effects on antenatal and postnatal outcomes in an individual randomised controlled trial

he study's objective was to determine the effectiveness of a task-sharing psychological treatment for perinatal depression using non-specialist community health workers. A double-blind individual randomised controlled trial was conducted in two antenatal clinics in the peri-urban settlement of Khayelitsha, Cape Town. Adult pregnant women who scored 13 or above on the Edinburgh Postnatal Depression rating Scale (EPDS) were randomised into the intervention arm (structured six-session psychological treatment) or the control arm (routine antenatal health care and three monthly phone calls). The primary outcome was response on the Hamilton Depression Rating Scale (HDRS) at three months postpartum (minimum 40% score reduction from baseline) among participants who did not experience pregnancy or infant loss (modified intention-to-treat po-pulation) (registered on Clinical Trials: NCT01977326). Of 2187 eligible women approached, 425 (19.4%) screened positive on the EPDS and were randomised; 384 were included in the modified intention-to-treat analysis (control: n = 200; intervention: n = 184). There were no significant differences in response on the HDRS at three months postpartum between the intervention and control arm. A task-sharing psychological treatment was not effective in treating depression among women living in Khayelitsha, South Africa. The findings give cause for reflection on the strategy of task-sharing in low-resource settings

The relationship between multidimensional poverty, income poverty and youth depressive symptoms: cross-sectional evidence from Mexico, South Africa and Colombia

Whereas monetary poverty is associated with increased risk of depressive symptoms in young people, poverty is increasingly understood as a multidimensional problem. However, it is yet to be understood how the associations between different dimensions of poverty and youth mental health differ across countries. We examine the relationship between multidimensional, as well as income poverty, and depressive symptoms in young people (age 11–25 years) across three middle-income countries. Based on harmonised data from surveys in Colombia, Mexico and South Africa (N=16 173) we constructed a multidimensional poverty index that comprised five deprivations. We used Poisson regression to examine relationships between different forms of poverty with depressive symptoms across the countries. Multidimensional poverty was associated with higher rates of depressive symptoms in the harmonised dataset (IRR (incidence rate ratio)=1.25, 95% CI 1.10 to 1.42), in Mexico (IRR=1.34, 95% CI 1.11 to 1.64) and Colombia (IRR=2.01, 95% CI 1.30 to 3.10) but not in South Africa, a finding driven by a lack of associations between child labour and health insurance coverage with depressive symptoms. There was only an association with income poverty and depressive symptoms in South Africa, not in Colombia or Mexico. Depressive symptoms were associated with individual deprivations such as school lag, child labour and lack of access to health services in the harmonised dataset, but not with household deprivations, such as parental unemployment and housing conditions, though the opposite pattern was observed in South Africa. Our findings suggest that the importance of specific dimensions of poverty for mental health varies across countries, and a multidimensional approach is needed to gain insights into the relationship between youth depression and poverty

Method Development for Determining the Removal of Metals from the Water Column under Transformation/Dissolution Conditions for Chronic Hazard Classification

An extension of the transformation/dissolution protocol (T/DP) was developed and evaluated as a tool to measure the removal of metals from the water column for chronic aquatic hazard classification. The T/DP extension (T/DP‐E) consists of 2 parts: T/DP‐E part 1, to measure metal removal from the water column via binding of metals to a substrate and subsequent settling, and T/DP‐E part 2, to assess the potential for remobilization of metals following resuspension. The T/DP‐E methodology (672‐h [28‐d] removal period, 1‐h resuspension event, and 96‐h resettling period) was tested using Cu, Co, and Sr solutions in the presence of a substrate. The metal removal rates varied from rapid removal for Cu to slower rates of removal for Co and Sr. The resuspension event did not trigger any increase in dissolved Cu, Co, or Sr. Additional 96‐h experiments were conducted using dissolved Ni, Pb, Zn, and Ag and supported the conclusion that the T/DP‐E is sufficiently robust to distinguish removal rates between metals with a wide range of reactivities. The proposed method provides a means to quantify the rate of metal removal from the water column and evaluate remobilization potential in a standardized and reliable way. Environ Toxicol Chem 2019;38:2032–2042. © 2019 SETAC.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151361/1/etc4471.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151361/2/etc4471_am.pd