Summary of patient baseline characteristics according to patient follow-up status.

<p>Summary of patient baseline characteristics according to patient follow-up status.</p

Evolution of median HIV-RNA load and CD4∶CD8 ratios in recently infected patients.

<p>HIV-RNA load (A) and CD4∶CD8 ratios (B) in patients with high HIV-RNA as compared to the other patients. Median and interquartile range are shown. HIV-RNA viral load groups are defined as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031859#s2" target="_blank">methods</a>. P-values are from Wilcoxon rank sum test between groups as follows: *p = 0.0001, **p = 0.038, *** p = 0.002. P-values from Wilcoxon Signed Rank between visits did not show significant differences. Numbers denote the n for each group at each time point.</p

Baseline virological and immunological parameters among individuals diagnosed with recent HIV infections by the BED-CEIA assay.

<p>Results are presented according to CD4 counts.</p><p>*CD4 counts available for 52/57 patients.</p

Kaplan-Meier survival estimates of hypertension development according to the independent risk factors at baseline: age (left), body mass index (centre) and estimated glomerular filtration rate (right).

<p>BMI: body mass index; eGFR: estimated glomerular filtration rate.</p

Multivariate analysis by Cox regression of predictors of IRIS development by etiology.

<p> <i>OI-IRIS: IRIS associated with systemic OI; MC-IRIS: IRIS associated with muco-cutaneous manifestations.</i></p

Cox regression analysis of risk factors for hypertension development.

<p>Cox regression analysis of risk factors for hypertension development.</p

Univariate and multivariate analysis by Cox regression of pre-cART factors potentially contributing to IRIS development (n = 136).

a<p> <i>Baseline WHO stage: 3 missing values; n: number of patients; p-m: persons-month of follow-up; HR: Hazard Ratio; CI: Confidence Interval; BMI: Body Mass Index; NVP: nevirapine; EFV: efavirenz; CD4 – BMI: combination of both independent predictors; Category 1: CD4 ≥50 cells/µL and BMI ≥18.5; Category 2: CD4 ≥50 cells/µL and BMI <18.5; Category 3: CD4 <50 cells/µL and BMI ≥18.5; Category 4: CD4 <50 cells/µL and BMI <18; * median.</i></p

Self-reported clinical symptoms according to status of HIV infection.

<p>*Recent HIV infection defined by BED-CEIA, CD4 counts >200 cell/µl and VL>400 copies/mL.</p

Kaplan Meier Survival estimates of IRIS development by the independent predictors identified.

<p>Kaplan Meier survival estimates of immune reconstitution inflammatory syndrome (IRIS) development according to the two independent predictors identified: pre-cART body mass index (A), pre-cART CD4 count (B), and the combination of both risk factors (C).</p

Patient flow chart.

<p>Patient flow chart.</p