1 research outputs found
Double-Stereodifferentiation in Rhodium-Catalyzed [2 + 2 + 2] Cycloaddition: Chiral Ligand/Chiral Counterion Matched Pair
The first enantioselective metal-catalyzed
[2 + 2 + 2] cycloaddition
involving a double asymmetric induction has been devised. It relies
on the use of an in situ generated chiral cationic rhodium(I) catalyst
with a matched chiral ligand/chiral counterion pair. Careful optimization
of the catalytic system, as well as of the reaction conditions, led
to atroposelective [2 + 2 + 2] pyridone cycloadducts with high ee’s
up to 96%. This strategy outperformed those previously described involving
a chiral ligand only or a chiral counterion only