Meta-analysis of the effect of the G-allele of <i>FAF1</i>-rs17106184 on 2-hour serum insulin in 6,260 individuals from the Inter99 study (n = 5,547), ADIGEN controls (n = 246), ADIGEN obese cases (n = 165) and Danish Family study (n = 302).

<p>Gray diamond represents combined change per risk allele and the 95% confidence interval. Gray squares represent effects size estimates (beta coefficients) in single studies sized according to their weight in the meta-analyses. The horizontal lines through the gray squares represent the 95% confidence interval. ob, obese. <i>p</i>, <i>P</i>-value. CI, confidence interval. W(fixed), study weight in the fixed effect meta-analysis.</p

Associations between the seven T2D risk variants and quantitative traits in up to 5,744 Danish individuals naive to glucose-lowering medication.

<p>Raw data are mean±SD or median (interquartile range) and are stratified according to genotype. Values of serum insulin and derived indexes of insulinogenic index, ISI_Matsuda, disposition index and BIGTT-AIR were natural logarithmical (ln) transformed before analysis. Effects represent beta coefficients and are shown for the T2D risk allele. <i>P</i>-values (<i>P</i>) are adjusted for age (BIGTT-AIR and BIGTT-SI) or sex and age (all other traits). <i>P</i>_adjBMI are <i>P</i>-values adjusted for age, sex and BMI. All analyses assume an additive genetic model. SE, standard error.</p><p>Associations between the seven T2D risk variants and quantitative traits in up to 5,744 Danish individuals naive to glucose-lowering medication.</p

T2D case-control analyses of up to 5,777 patients from Inter99 (n = 320), Health 2006 (n = 166), Health 2008 (n = 18), Steno Diabetes Center (n = 1,424), ADDITION (n = 1,870) and Vejle Biobank (n = 1,979) and up to 7,956 individuals with normal fasting glucose from Inter99 (n = 4,590), Health 2006 (n = 2,412), Health 2008 (n = 528) and Vejle Biobank (n = 426).

<p>Number of cases vs. number of controls is shown as 0/1/2 risk alleles. Odds ratios (OR) and <i>P</i>-values (<i>P</i>) are adjusted for age and sex. OR_adjBMI and <i>P</i>_adjBMI are adjusted for age, sex and BMI. SNP, single nucleotide polymorphism. RA, risk allele. RAF, risk allele frequency. CI, confidence interval.</p><p>T2D case-control analyses of up to 5,777 patients from Inter99 (n = 320), Health 2006 (n = 166), Health 2008 (n = 18), Steno Diabetes Center (n = 1,424), ADDITION (n = 1,870) and Vejle Biobank (n = 1,979) and up to 7,956 individuals with normal fasting glucose from Inter99 (n = 4,590), Health 2006 (n = 2,412), Health 2008 (n = 528) and Vejle Biobank (n = 426).</p

Meta-analysis of the effect of the C-allele of <i>TMEM154</i>-rs6813195 on insulinogenic index in 6,486 individuals from the Inter99 study (n = 5,181), Health 2008 study (n = 592), ADIGEN controls (n = 246), ADIGEN obese cases (n = 165) and Danish Family study (n = 302).

<p>Gray diamond represents combined change per risk allele and the 95% confidence interval. Gray squares represent effects size estimates (beta coefficients) in single studies sized according to their weight in the meta-analyses. The horizontal lines through the gray squares represent the 95% confidence interval. ob, obese. <i>p</i>, <i>P</i>-value. CI, confidence interval. W(fixed), study weight in the fixed effect meta-analysis.</p

Meta-analysis of the effect of the C-allele of <i>TMEM154</i>-rs6813195 on disposition index in 6,486 individuals from the Inter99 study (n = 5,181), Health 2008 study (n = 592), ADIGEN controls (n = 246), ADIGEN obese cases (n = 165) and Danish Family study (n = 302).

<p>Gray diamond represents combined change per risk allele and the 95% confidence interval. Gray squares represent effects size estimates (beta coefficients) in single studies sized according to their weight in the meta-analyses. The horizontal lines through the gray squares represent the 95% confidence interval. ob, obese. <i>p</i>, <i>P</i>-value. CI, confidence interval. W(fixed), study weight in the fixed effect meta-analysis.</p

Association of genome-wide variants with plasma fT4 concentrations.

<p>SNPs that passed QC are plotted on the x-axis according to their chromosomal position against their–log10(<i>p</i>-value). The results were considered genome-wide significant with a <i>p</i><5·10⁻⁸ and a replication threshold was set at <i>p</i><1·10⁻⁶.</p

Effects of genetic variants known to associate with plasma TSH or fT4 concentrations.

<p>Effects from studies in adults compared to the effects of the variants in the cohort from the Danish Childhood Obesity Biobank (TDCOB). Effect sizes are shown in standard deviations (SD) of the rank-normalized TSH or fT4 distribution with 95% confidence intervals. EA is the Effect Allele (from the literature). I² is the measure for heterogeneity between the TDCOB cohort and literature. p(Hetro) is the p-value for the heterogeneity.</p

Lead SNPs from the discovery-, replication- and meta-analyses.

<p>Lead SNPs from the discovery-, replication- and meta-analyses.</p

Association of genome-wide variants with plasma TSH concentrations.

<p>SNPs are plotted on the x-axis according to their chromosomal position against the–log10(<i>p</i>-value). The results were considered genome-wide significant with a <i>p</i><5·10⁻⁸. A threshold for replication was set at <i>p</i><1·10⁻⁶.</p