The Effects of daily diabetina tea consumption on glycosylated hemoglobin, fasting glucose and lipid levels, and body mass index in normoglycemic individuals

Type 2 diabetes mellitus is a chronic disease responsible for high levels of morbidity and mortality in the United States, especially among some ethnic minority populations. Diabetina tea, a commercially-available herbal blend tea, is a well known herbal remedy for high blood sugar among Hispanic American diabetics. This study will examine the effect of twice-daily unsweetened Diabetina tea consumption over an 8 week period on glucose (sugar) and lipid (fat) metabolism. Potential effects of Diabetina tea consumption on glucose metabolism will be measured by glycosylated hemoglobin (HbA1c) and fasting glucose tests, while the potential effects of Diabetina tea consumption on lipid metabolism will be measured by fasting blood lipid levels, in addition to body mass index (BMI) and waist circumference (WC) measurements

RNA expression of TLR10 in normal equine tissues

Background: Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. Results: This paper describes the genetic structure of the Equine TLR10 gene and its RNA expression in a range of horse tissues. It describes the phylogenetic analysis of the Equine TLR1,6,10,2 annotations in the horse genome, firmly identifying them in their corresponding gene clades compared to other species and firmly placing the horse gene with other TLR10 genes from odd-toed ungulates. Additional 3’ transcript extensions to that annotated for TLR10 in the horse genome have been identified by analysis of RNAseq data. RNA expression of the equine TLR10 gene was highest in peripheral blood mononucleocytes and lymphoid tissue (lymph nodes and spleen), however some expression was detected in all tissues tested (jejunum, caudal mesenteric lymph nodes, bronchial lymph node, spleen, lung, colon, kidney and liver). Additional data on RNAseq expression of all equine TLR genes (1–4 and 6–10) demonstrate higher expression of TLR4 than other equine TLRs in all tissues. Conclusion: The equine TLR10 gene displays significant homology to other mammalian TLR10 genes and could be reasonably assumed to have similar fuctions. Its RNA level expression is higher in resting state PBMCs in horses than in other tissues