44 research outputs found
Two-particle localization and antiresonance in disordered spin and qubit chains
We show that, in a system with defects, two-particle states may experience
destructive quantum interference, or antiresonance. It prevents an excitation
localized on a defect from decaying even where the decay is allowed by energy
conservation. The system studied is a qubit chain or an equivalent spin chain
with an anisotropic () exchange coupling in a magnetic field. The chain
has a defect with an excess on-site energy. It corresponds to a qubit with the
level spacing different from other qubits. We show that, because of the
interaction between excitations, a single defect may lead to multiple localized
states. The energy spectra and localization lengths are found for
two-excitation states. The localization of excitations facilitates the
operation of a quantum computer. Analytical results for strongly anisotropic
coupling are confirmed by numerical studies.Comment: Updated version, 13 pages, 5 figures To appear in Phys. Rev. B (2003
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation
Sex disparities in cardiac homeostasis and heart disease are well documented, with differences attributed to actions of sex hormones. However, studies have indicated sex chromosomes act outside of the gonads to function without mediation by gonadal hormones. Here, we performed transcriptional and proteomics profiling to define differences between male and female mouse hearts. We demonstrate, contrary to current dogma, cardiac sex disparities are controlled not only by sex hormones but also through a sex-chromosome mechanism. Using Turner syndrome (XO) and Klinefelter (XXY) models, we find the sex-chromosome pathway is established by X-linked gene dosage. We demonstrate cardiac sex disparities occur at the earliest stages of heart formation, a period before gonad formation. Using these datasets, we identify and define a role for alpha-1B-glycoprotein (A1BG), showing loss of A1BG leads to cardiac defects in females, but not males. These studies provide resources for studying sex-biased cardiac disease states
Differential contributions of set-shifting and monitoring to dual-task interference
It is commonly argued that complex behaviour is regulated by a number of “executive functions” which work to co-ordinate the operation of disparate cognitive systems in the service of an overall goal. However, the identity, roles, and interactions of specific putative executive functions remain contentious, even within widely accepted tests of executive function. The authors present two experiments that use dual-task interference to provide further support for multiple distinct executive functions and to establish the differential contributions of those functions in two relatively complex executive tasks – Random Generation and the Wisconsin Card Sorting Test. Results are interpreted in terms of process models of the complex executive tasks
Model Checking Durational Probabilistic Systems
Abstract. We consider model-checking algorithms for durational probabilistic systems, which are systems exhibiting nondeterministic, probabilistic and discrete-timed behaviour. We present two semantics for durational probabilistic systems, and show how formulae of the probabilistic and timed temporal logic PTCTL can be verified on such systems. We also address complexity issues, in particular identifying the cases in which model checking durational probabilistic systems is harder than verifying non-probabilistic durational systems.