Evaluating unspecific oxidative stress parameters in the sera of patients with irritable bowel syndrome

Objective: Irritable bowel syndrome (IBS) is a common global condition characterized by abdominal pain and alterations in bowel habits not caused by other organic diseases and its etiopathogenesis has not been elucidated. In this study, we aimed to evaluate the oxidative stress parameters in patients with IBS. Materials and methods: Fifty patients diagnosed with IBS using the Rome III criteria and a control group of 50 healthy subjects were included in the study. Oxidative stress parameters including total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values were analyzed from all study subjects. Results: Compared to the controls; the TOS and OSI values were significantly higher, and the TAS value was significantly lower in IBS patients (p < 0.001 for all). Conclusions: In present study we demonstrated that oxidative stress increased and antioxidant capacity decreased in IBS, and antioxidants might be beneficial in the supportive treatment for IBS

Social problem solving and coping skills of medical students

Purpose: The aim of this study was to evaluate medical students' social problem solving and coping skills. Material and Methods: In this correlational descriptive study, data were gathered from 457 medical students. Social Problem Solving Inventory and Social Problem Coping Behaviours Inventory were used. Results: The most preferred activities when the students face a problem were talking with friends (87.1%), talking with special persons (85.4%), sleeping (82.6%), talking with family members (81.6%), and eating (79.8%). The ratio of the behaviors that can be deemed risky were exhibiting aggressive and violent behaviors (18.9%), drinking alcohol (18.7%), smoking (17.6%), playing games of chance (16.9%), and using substance (3.8%). There was a positive relationship between total scores of Social Problem Solving Inventory and Social Problem Coping Behaviours Inventory. It is found that immature social problem solving ability has increased the risk of unfavourable behaviours by 3.1 fold. Conclusion: Social problem solving ability is significantly correlated with coping behaviours and may predict it. Medical students who are the doctors and the role models of the future need to develop their social problem solving skills in addition to clinical problem solving skills. [Cukurova Med J 2016; 41(4.000): 721-731

A conceptual framework for barriers of circular supply chains for sustainability in the textile industry

Yarimoglu, Emel/0000-0002-0484-5006; Kazancoglu, Ipek/0000-0001-8251-5451; Kazancoglu, Yigit/0000-0001-9199-671XWOS: 000551087300001Circular economy is a contemporary concept including usage of renewable materials and technologies. the transition to the circular economy creates value through closed-loop systems, reverse logistics, eco-design, product life cycle management, and clean production. the aim of the study was to propose a holistic conceptual framework for barriers of circular supply chain for sustainability in the textile industry. Within this aim, an in-depth literature review on barriers was conducted by covering all supply chain stages and circular initiatives in textile industry. Then, a focus group study was implemented. in the focus group study, barriers related to supply chains that prevent companies to implement the circular economy were discussed and validated. As a result, a total of 25 barriers were classified under nine main categories such as (a) management and decision-making, (b) labour, (c) design challenges, (d) materials, (e) rules and regulations, (f) lack of knowledge and awareness, (g) lack of integration and collaboration, (h) cost, and (i) technical infrastructure

A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma

WOS: 000314717400008PubMed ID: 23292496Medulloblastoma is the most common pediatric central nervous system tumor; however, the causes are not well established. There has been some emphasis on mutations in developmental pathways and their impact on tumor pathology in hereditary diseases, but, in order to better understand the nature of diseases like medulloblastoma, other mechanisms also require attention. The purpose of this review is to provide an overview of the main genes involved in neurodevelopment, their downstream targets, and modulatory links by growth factors. Occurrence of pediatric brain tumors including medulloblastoma are mostly sporadic, but some hereditary diseases like Li-Fraumeni syndrome, Gorlin's syndrome, Turcot's syndrome, and Rubenstein-Tarbi syndrome are known to contribute their development as consequences of germline mutations at specific points: DNA-repairing gene Tp53 for Li-Fraumeni syndrome or Patch for Gorlin's, and apoptosis-related gene product adenomatous polyposis coli for Turcot's disease. Intracellular relations at molecular level and future therapeutics that specifically target the corresponding pathways should be well understood in order to prevent and cure childhood medulloblastoma

Melatonin Production and Bioavailability

WOS: 00035413460000

Comparative effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease: a prospective randomized trial

Aim: The aim of this study was to compare the effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease. Methods: Consecutively 88 patients who had hepatic steatosis with type-2 DM were recruited for the study. For randomization, 28 patients who had exclusion criteria were excluded from the study. The remaining patients (n = 60) were randomized into two groups. Only diet therapy were given to Group 1(n = 30) and metformin 2 gram/day plus diet were given to group 2 (n = 30) during 3 months. During the follow-up period 5 patients in group 1 and 1 patient in group 2 did not come for follow-up. Therefore we evaluated 25 patients in group 1 and 29 patients in group 2. Omentin levels were analyzed at admission and at the end of the study.Results: There was a statistically significant difference in the values of body weight, body mass index, waist and hip circumference, body fat percentage (%), and omentin in group 1; and in the values of body weight, BMI, waist and hip circumference, body fat percentage (%), and omentin in group 2. Omentin levels were significantly decreased with the treatment in both groups (5.37 ± 1.31 ng/ml to 4.00 ± 1.46 ng/ml in group 1; 6.96 ± 2.10 ng/ml to 3.92 ± 0.89 ng/ml in group 2, p = 0.001 respectively). When compared the percentage of changes between two groups, it was found that the omentin value was more decreased in group 2 (p = 0.032).Conclusions: Although diet and diet plus metformin treatment decreased the omentin levels, diet plus metformin treatment would be more beneficial in type 2 diabetes patients with nonalcoholic fatty liver disease.<p

Deneysel temas tipi yanıklarda topikal Alpinia officinarum (havlıcan) tedavisinin akut etkilerinin araştırılması ve topikal gümüş sülfadiazin tedavisi ile karşılaştırılması

BACKGROUND: It was aimed to determine whether Alpinia officinarum (AO) (galangal), which has been regarded to be effective on wound healing, is healing on experimental contact type burns and compare its effects with silver sulfadiazine (SSD). METHODS: Thirty-five rats were divided into five groups of seven rats each group. Superficial second degree burns were formed by contacting a 1x1 cm copper tip which was kept at 100 degrees C constant temperature to the three shaved areas on the back of rats without applying any pressure for 10 s. All groups were irrigated with a 100 cc saline solution for 2 min. Any procedure or treatment was not applied to Group I (Control). Group II (Burn Control) was only irrigated, Group III (SSD) was applied topical SSD 4 times, with 6-h intervals (at h 0, 6, 12 and 18), Group IV (Galangal) was applied topical AO 4 times, and Group V (Gel) was applied placebo topical material, used for the preparation of topical AO, 4 times. Wound healing findings were evaluated histopathologically. RESULTS: In the galangal group, it was found that collagen discoloration didn't penetrate into deep dermis compared to other groups; epidermis, hair follicles, and sebaceous glands remained protected compared to the burn control group, and there was a thicker layer of epidermis. It was found that the galangal group was the closest group to the control group histologically. In the galangal group, it was determined that the number of vessels and total hair follicles were significantly higher in the 8th h and 4th h respectively (p<0.05), while epidermal thickness and number of degenerated hair follicles were significantly higher in all hours compared to other three groups (p<0.05). It was determined that galangal group had the lowest scores in the evaluation of edema, polymorphonuclear leukocytes infiltration, collagen discoloration, injury of vessels, hair follicles and sebaceous glands in comparisons between groups and within groups' own processes. CONCLUSION: Administrating AO containing gel 4 times a day within the first 24 h is effective in the experimental contact type second degree burn model. It is significantly superior to SSD treatment, especially in the first 8 h of administration.Ege University Scientific Research Projects Fund [2013TIP-027]This study was supported by the Ege University Scientific Research Projects Fund as project 2013TIP-027

Effect of PPAR-gamma agonists on macrophage activation in type2 diabetes mellitus

WOS: 000435650500003Aim: Recently, it has been proposed that inflammation triggered by macrophages as the pathogenic mechanism linked to the development of obesity-related insulin resistance. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists which increase the insulin receptor sensitivity. might improve glycemic control by enhancing insulin sensitivity and ameliorate the impaired lipid profile. In this study, we assessed the effect of rosiglitazone (PPAR-gamma agonist) on the insulin resistance and inflammatory markers. Material and Method: Thirty patients (11 men. 19 women) with type II diabetes mellitus (DM) were taken into the study. They were treated by rosiglitazone in a dose of 4mg/day as well as a diet for 12 weeks. Results: Rosiglitazone treatment significantly decreased HbA1c (p<0,01), IR-HOMA, hsCRP (p<0,01), triglyceride levels (p<0,05), CETP activity (p<0,01) and basal serum oxidation (TBARS levels, p<0,05). However, Chitotriosidase activity significantly increased after Rosiglitazone treatment (p<0,01). TNF, IL-6, sTNFR1, and sTNFR2 levels showed no statistically significant difference compared to their basal levels. Discussion: Rosiglitazone might treat diabetes by mediating glucose/lipid metabolism and preventing lipid oxidation in patients with DM. On the other hand, it has a dual role on inflammation; while it might induce macrophage activation suggesting its pro-inflammatory effect, It might also reduce the CRP levels by lowering gene expression suggesting its anti-inflammatory effect

Urothelial Carcinoma Concomitant With Malakoplakia In Non-Functioning Nephrolithic Kidneys

Nephrolithic non-functioning kidney and malakoplakia are major health problems. Kidney function cannot be fulfilled and also this leads to a high risk of development of urothelial neoplasm. We report herein a case of urothelial carcinoma concomitant with malakoplakia in non-functioning nephrolithic kidneys