Boys\u27 participation in junior secondary school physical education and sport

According to social lore, boys are meant to be good at Physical Education and sport. There is, however, increasing evidence to the contrary and it is now essential to consider why boys drop out of Physical Education and sport. There has been a good deal of research and subsequent literature detailing the plight of girls\u27 involvement in Physical Education and sport. However, a dearth of literature and research exists where boys Physical Education and sport are concerned. Out of research comes practical implementation strategies that can be adopted by teachers to create a more favourable learning environment. Extensive research on boys\u27 Physical Education and sport has been carried out in a number of schools in the Perth metropolitan region as well Western Australian country schools. The schools involved have been randomly selected from a multitude of regions to create a broad cross section of data. They include both government and non-government schools. The participants involve boys in Years 8, 9, and 10. Approximately 40 boys who do not enjoy Physical Education and sport, as identified by their Physical Education teachers, took part in group interviews . From these interviews a questionnaire was developed and completed by over 600 boys in 14 different schools..

Systematic Observation : Helping You Coach More Effectively

Have your athletes reached a plateau? Despite everything you do and say, the improvements are minuscule? Perhaps then, it might be time to not only look at the athletes but also yourself. During every training session you constantly monitor your athletes' training behaviour, their fitness, skills and tactical abilities and give them feedback to improve themselves. But do you monitor yourself as closely? And if not, why not? By helping your own coaching behaviour you're ultimately helping your athletes. This article aims to give you some ideas to get you thinking about improving your own behaviour. The methods are time tested and have assisted coaches in numerous sports (Table I) around the world to im~roveth eir coachina

Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in the kinase domain such as the most prevalent G2019S mutation have been associated with an increased risk for the development of Parkinson’s disease (PD). Given this genetic validation for inhibition of LRRK2 kinase activity as a potential means of affecting disease progression, our team set out to develop LRRK2 inhibitors to test this hypothesis. A high throughput screen of our compound collection afforded a number of promising indazole leads which were truncated in order to identify a minimum pharmacophore. Further optimization of these indazoles led to the development of MLi-2 (<b>1</b>): a potent, highly selective, orally available, brain-penetrant inhibitor of LRRK2