Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients

The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation

International Journal of Pharma and Bio Sciences RESEARCH ARTICLE BIOCHEMISTRY EFFECT OF CIGARETTE SMOKING ON BLOOD SODIUM AND POTASSIUM LEVELS IN SUDANESE SUBJECTS

This study aimed to investigate the effect of cigarette smoking on plasma sodium and potassium levels. Atomic emission flame spectrophotometry was used to measure plasma sodium and potassium in sixty subjects, thirty smokers and thirty non-smokers as matched controls. The plasma sodium and potassium were analyzed before and after smoking in the smokers, while the analysis was done once in non-smoker cohort. There was a significant increase in sodium level immediately after smoking among smokers (p < 0.05) and no significant change in potassium level. No change was found in plasma sodium level between smokers (before smoking) and non-smokers. In addition, there is a decrease in plasma potassium level among smokers (before smoking) in comparison to non-smokers; however, it is statistically not significant. This study reveals that cigarette smoking has an immediate increasing effect on plasma sodium level. It is recommended that cigarette smoking should be avoided especially before blood sodium measurement. This article can be downloaded from www.ijpbs.net B- 75KEYWORDS Sudan, Shendi, Electrolytes, smokers, sodium, potassium