6 research outputs found
Clinical pregnancies and live births according to type of treatment in the prospective cohort. Logistic regression.
<p>Clinical pregnancies and live births according to type of treatment in the prospective cohort. Logistic regression.</p
Baseline characteristics and obstetric history of study participants (N = 1107).
<p>*Information not provided by couples</p>Δ<p>32 ectopic pregnancies, 1 ongoing pregnancy, 44 termination</p>□<p>3 ectopic pregnancies, 3 ongoing pregnancy, 1 termination.</p
The figure depicts the entire cohort of women enrolled.
<p>The figure depicts the entire cohort of women enrolled.</p
Cumulative live-birth rate during the follow-up and stratified according to the age, and calculated assuming that women who did not return for ART had the same chance as those who remained in treatment (Optimistic, Panel A) or no chance of a pregnancy resulting in a live-birth (Conservative, Panel B).
<p>In both models, the age-stratified curves in women from 38 to 40 yrs and >40 yrs were significantly different from those of women <35 yrs (p<0.001) and those in women from 35 to 38 yrs (p<0.01 and <0.05, respectively).</p
Main obstetric outcomes of cycles with and without medical treatment.
<p>Main obstetric outcomes of cycles with and without medical treatment.</p
Analysis of <i>MTNR1B</i> gene polymorphisms in relationship with <i>IRS2</i> gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly
<p>Genome-wide association studies pinpointed common variants in or near the <i>MTNR1B</i> gene encoding MT2 melatonin receptor to be strongly associated with fasting glucose levels. <i>IRS2</i> gene polymorphisms impact insulin resistance and epicardial fat (EF) thickness, which in turn is correlated with visceral adiposity, cognitive ability and risk for metabolic plus cardiovascular disease. We aimed to discover the interactions between <i>MTNR1B</i> and <i>IRS2</i> gene polymorphisms, insulin sensitivity, EF thickness and cognitive performance in the elderly. In 60 subjects aged 60Â years and older, we evaluated five single nucleotide polymorphisms (SNPs) within the <i>MTNR1B</i> locus (rs10830962, rs4753426, rs12804291, rs10830963, rs3781638), the Gly1057Asp variant of <i>IRS2</i> gene (rs1805097), biochemical parameters, cognitive performance by the Mini Mental State Examination (MMSE) and EF thickness by transthoracic echocardiography. We found that <i>MTNR1B</i> and <i>IRS2</i> gene variants impacted EF thickness, lipid profile and glucose homeostasis. <i>IRS2</i> but not <i>MTNR1B</i> variants impacted MMSE scores. In conclusion, <i>MTNR1B</i> SNPs interact with <i>IRS2</i> gene variant, correlate with the amount of epicardial adipose tissue and impact glucose homeostasis and lipid profile influencing cardiometabolic risk.</p