Epithelial-to-mesenchymal transition and neoangiogenesis in laryngeal squamous cell carcinoma

Biological and clinical data have indicated that epithelial-mesenchymal transition (EMT) and angiogenesis contribute to tumour growth, invasion, and metastasis. EMT is the phenomenon in which epithelial cells transform into mesenchymal cells which is mainly characterised by the loss of intercellular adhesion, and an increase in cellular migration and mobility. This study aimed to evaluate the clinicopathologic significance of the combined immunohistochemical expression E-cadherin and CD105 in 85 (43 glottic and 42 supraglottic) previously untreated patients with laryngeal squamous cell carcinoma and to assess the correlation of their expression. A staining score of E-cadherin was given based on the percentage (0–100%) of cells stained. The rounded mean value of the positive-stained microvessels for CD105 counted in four hot spots was used as the final intratumoral microvessel density (MVD). MVD was significantly higher in patients with advanced T3– T4 category (p=0.020) and TNM stage (p=0.001). Nodal metastases were more frequent in the cases with low E-cadherin expression (p=0.012). A high MVD was an independent predictor of tumour recurrence (p=0.015). The log-rank test showed a significant difference in the disease-free interval in patients stratified according to MVD (p=0.034). Expression of CD105 could help predict patients with an increased risk of developing locoregional recurrence after treatment. Reduction of E-cadherin is a potential predictor of lymph node metastases

The Struggle of the Indigenous Peoples of Crimea for Survival

Crimean Tatars: today, this small number of people is known all over the world. The history of the Crimean Tatars is full of complicated moments and tragic events, as well as the centuries-old history of Crimea itself. On repeated occasions, representatives of the Indigenous Crimean Tatar Peoples were persecuted and repressed—their territories were seized, they were deported to Central Asia in cattle wagons, and they were not allowed to return to their homeland. Because of such inhumane policies, the number of Crimean Tatars has decreased significantly over the years. In an interview with the author of this chapter, historian Gulnara Abdullaeva stated that there are only about 300,000 Tatars who live compactly in their historical homeland—in Crimea (more than 100,000 still remain in Uzbekistan). The events of recent years served to be a true tragedy for them. Because of their disagreement with the occupation of Crimea by Russia, they are continuously subjected to pressure and repression by the Russian authorities of the peninsula. This is recognized in resolutions made by the United Nations General Assembly. However, the Tatars’ extraordinary ability to unite and their centuries-old experience of non-violent struggle for their rights makes it possible to keep Crimean issues on the agenda at the international level. Crimean Tatars sincerely believe that soon things are bound to improve and people will live freely and will be able to return to their homeland. The older generation often repeats: “We survived deportation in 1944, heat and cold, hunger and death, inhumane conditions of life in a foreign land. After nearly half a century, we were able to return to our homeland. We will definitely survive this, too.” And trust me, they are right. Their great desire to live freely on their land will overcome any obstacle

PREFORMATIVE, PERFORMATIVE AND NARATIVE IN CREATIVE PERSON CENTERED PSYCHOPHARMACOTHERAPY

Psychopharmacotherapy does not stand alone. The act of prescribing involves much than solely choosing "best" medication. It seems that somewhere in the process of trying to objectify and scientify our therapy, we have neglected an important and effective dimensions of it. Psychopharmacology should consider much more than just biological dimension of drugs. Psychological, social and behavioral factors that influence drug metabolism, efficacy and side-effects are largely overlooked. Obviously, the subtext of information provided by the medical professional inevitably contains suggestion. Important part of that subtext is consisted in way we think of it, we talk of it and we perform that information. Defining of preformative and performative psychopharmacotherapy was atempted as well as desciption of narrative creative person-centered psychopharmacotherapy. Studies that indicate that medicines (SSRI) do not work on its own but as amplifier of the influence of the living conditions on mood are provided. Undirected susceptibility to change hypothesis which request acknowledging the importance of social, psychological, environmental factors to explain such the mechanisms underlying the recovery from the disease is explained. Understanding the role of medicines (SSRIs) as amplifier of the influence of the living conditions on mood represents a critical step in developing a creative, person-centered psychopharmacotherapy aimed at better matching patients with treatment and avoiding potential harmful consequences

Epithelial-to-mesenchymal transition and neoangiogenesis in laryngeal squamous cell carcinoma

Biological and clinical data have indicated that epithelial-mesenchymal transition (EMT) and angiogenesis contribute to tumour growth, invasion, and metastasis. EMT is the phenomenon in which epithelial cells transform into mesenchymal cells which is mainly characterised by the loss of intercellular adhesion, and an increase in cellular migration and mobility. This study aimed to evaluate the clinicopathologic significance of the combined immunohistochemical expression E-cadherin and CD105 in 85 (43 glottic and 42 supraglottic) previously untreated patients with laryngeal squamous cell carcinoma and to assess the correlation of their expression. A staining score of E-cadherin was given based on the percentage (0–100%) of cells stained. The rounded mean value of the positive-stained microvessels for CD105 counted in four hot spots was used as the final intratumoral microvessel density (MVD). MVD was significantly higher in patients with advanced T3– T4 category (p=0.020) and TNM stage (p=0.001). Nodal metastases were more frequent in the cases with low E-cadherin expression (p=0.012). A high MVD was an independent predictor of tumour recurrence (p=0.015). The log-rank test showed a significant difference in the disease-free interval in patients stratified according to MVD (p=0.034). Expression of CD105 could help predict patients with an increased risk of developing locoregional recurrence after treatment. Reduction of E-cadherin is a potential predictor of lymph node metastases

PREFORMATIVE, PERFORMATIVE AND NARATIVE IN CREATIVE PERSON CENTERED PSYCHOPHARMACOTHERAPY

Psychopharmacotherapy does not stand alone. The act of prescribing involves much than solely choosing "best" medication. It seems that somewhere in the process of trying to objectify and scientify our therapy, we have neglected an important and effective dimensions of it. Psychopharmacology should consider much more than just biological dimension of drugs. Psychological, social and behavioral factors that influence drug metabolism, efficacy and side-effects are largely overlooked. Obviously, the subtext of information provided by the medical professional inevitably contains suggestion. Important part of that subtext is consisted in way we think of it, we talk of it and we perform that information. Defining of preformative and performative psychopharmacotherapy was atempted as well as desciption of narrative creative person-centered psychopharmacotherapy. Studies that indicate that medicines (SSRI) do not work on its own but as amplifier of the influence of the living conditions on mood are provided. Undirected susceptibility to change hypothesis which request acknowledging the importance of social, psychological, environmental factors to explain such the mechanisms underlying the recovery from the disease is explained. Understanding the role of medicines (SSRIs) as amplifier of the influence of the living conditions on mood represents a critical step in developing a creative, person-centered psychopharmacotherapy aimed at better matching patients with treatment and avoiding potential harmful consequences

Maybe you can turn me on: CRISPRa-based strategies for therapeutic applications

Since the revolutionary discovery of the CRISPR-Cas technology for programmable genome editing, its range of applications has been extended by multiple biotechnological tools that go far beyond its original function as "genetic scissors". One of these further developments of the CRISPR-Cas system allows genes to be activated in a targeted and efficient manner. These gene-activating CRISPR-Cas modules (CRISPRa) are based on a programmable recruitment of transcription factors to specific loci and offer several key advantages that make them particularly attractive for therapeutic applications. These advantages include inter alia low off-target effects, independence of the target gene size as well as the potential to develop gene- and mutation-independent therapeutic strategies. Herein, I will give an overview on the currently available CRISPRa modules and discuss recent developments, future potentials and limitations of this approach with a focus on therapeutic applications and in vivo delivery

The influence of talent management on organisational performance in Bosnia & Herzegovina as a developing country

In today\u27s globalized, fast-changeable, and digitalized market, companies strongly need and seek talents, who, besides basic skills, possess higher levels, as well as the optimal mix of different competencies and qualifications. Attracting the best employees, developing and retaining them represents a crucial success factor for any firm and requires well-organized talent management. The purpose of this study is to analyze the influence of talent management, viewed through attracting, developing, and retaining talents, on organizational performance improvement in companies in Bosnia and Herzegovina. Data collection is based on a questionnaire, related to core elements of talent management and organizational performance (profitability and sales growth), with respondents from the population of talented managers, who work in companies in Bosnia and Herzegovina. The findings indicate that talent management has a positive statistically significant influence on observed organizational performance in companies in Bosnia and Herzegovina. Since talented managers are a key strategic resource, who lead organizations to accomplish excellent organizational performance, companies in developing countries need to tailor effective and customized talent management strategies, to achieve continuous improvement of organizational outcomes