8 research outputs found

    Celtic gold torcs

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    A POWER TO INTRIGUE? EXPLORING THE ‘TIMELESS’ QUALITIES OF THE SO‐CALLED ‘GROTESQUE’ IRON AGE TORC FROM SNETTISHAM, NORFOLK

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    Sometimes we come across objects that truly intrigue us. Not necessarily because they are great examples of art, or because they are made of precious materials, but because there is some other quality which captures our attention. One of these can be age. Just as age adds character to people’s faces, the patina of an object or visible signs of damage and use instils an object with a certain ‘charisma’ or ‘aura’. This paper examines in detail the so-called grotesque torc, a neck-ring dating to the Iron Age which has been extensively repaired. The repairs are crude and obvious, which gives the object its distinctive appearance. It is argued that these signs of age, inscribed onto the artefact through its life, imbued the torc with a timeless ‘anachronic’ quality: its visible age manifests a certain charisma or aura, helping facilitate a plural relationship with time.British Museu

    A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast

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    Protein localization plays a central role in cell biology. Although powerful tools exist to assay the spatial and temporal dynamics of proteins in living cells, our ability to control these dynamics has been much more limited. We previously used the phytochrome B– phytochrome-interacting factor light-gated dimerization system to recruit proteins to the plasma membrane, enabling us to control the activation of intracellular signals in mammalian cells. Here we extend this approach to achieve rapid, reversible, and titratable control of protein localization for eight different organelles/positions in budding yeast. By tagging genes at the endogenous locus, we can recruit proteins to or away from their normal sites of action. This system provides a general strategy for dynamically activating or inactivating proteins of interest by controlling their localization and therefore their availability to binding partners and substrates, as we demonstrate for galactose signaling. More importantly, the temporal and spatial precision of the system make it possible to identify when and where a given protein's activity is necessary for function, as we demonstrate for the mitotic cyclin Clb2 in nuclear fission and spindle stabilization. Our light-inducible organelle-targeting system represents a powerful approach for achieving a better understanding of complex biological systems
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