Pengaruh Pemberian Ekstrak Buah Semangka (Citrullus Lanatus) Terhadap Penurunan Kadar Asam Urat Pada Tikus Putih Jantan Galur Wistar (Rattus Novergicus)

ABSTRACT THE EFFECT OF WATERMELON EXTRACT (Citrullus lanatus) ON THE DECREASE OF URIC ACID LEVEL IN WHITE MALE RATS WISTAR (Rattus novergicus) Riri Eltadeza, Devi Usdiana Rosyidah Faculty Of Medicine, Muhammadiyah University of Surakarta Backround : Citrullus lanatus is rich content of flavonoids, alkaloids, saponins, glycosides, tannins, and phenolic compounds. Flavonoid has an effect on decreasing uric acid levels by inhibiting the action of xanthine oxidase enzymes that can reduce uric acid levels of white rats. Objective: To determine the effect of watermelon extract on the decrease of uric acid level in white male rats wistar. Method: This research is a laboratory experimental research with pretest-post test method with control group design. It used 25 male white rats of wistar strain 2-3 months old with 150-250 gram weight with potassium oxonate induced and divided into 5 groups: negative control group (aquades), positive control (allopurinol 2,52 mg / 200gBB), treatment of extract 500 mg 200gBB, 1000 mg/200gBB, and 1500 mg/200gBB. Result: One Way Anova test 2 hours after treatment was obtained p = 0,049 and 4 hours after treatment was obtained p = 0.003 (p <0.05) this means that there was significant difference of uric acid level in each group after treatment. In the LSD test 2 hours after treatment the results were found to different significantly in groups K (-) - K (+) and K (+) - D1. LSD 4 hours after treatment showed different significantly results in groups K (-) - K (+), K (-) - D2, K (-) - D3, and K (+) – D1. Conclution : Watermelon Extract has an effect on decreasing uric acid levels in white male rats wistar. The most optimal effect of uric acid reduction is watermelon extract dose III 1500 mg/200gBB. Keywords: Citrullus lanatus, Uric acid, Rat wista