A Proposed Model for Predicting Employee Turnover of Information Technology Specialists Using Data Mining Techniques

This article proposes a data mining framework to predict the significant explanations of employee turn-over problems. Using Support vector machine, decision tree, deep learning, random forest, and other classification algorithms, the authors propose features prediction framework to determine the influencing factors of employee turn-over problem. The proposed framework categorizes a set of historical behavior such as years at company, over time, performance rating, years since last promotion, and total working years. The proposed framework also classifies demographics features such as Age, Monthly Income, and Distance from Home, Marital Status, Education, and Gender. It also uses attitudinal employee characteristics to determine the reasons for employee turnover in the information technology sector. It has been found that the monthly rate, overtime, and employee age are the most significant factors which cause employee turnover

The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

The scope of this chapter is to review the significant effect that nanomedicine has had in the treatment of inflammatory diseases. Nanotechnology has been widely studied in the last decade and proved to be an encouraging strategy in the healthcare system and the medical field. This novel technology provides a vast number of nanomaterials and tools that could actually diagnose and treat different inflammatory disorders and conditions. An enormous amount of in vivo and in vitro research was conducted by many groups to validate the positive contribution that nanoparticles have in regard to the treatment of inflammation and its associated illnesses. This contribution is due to the fact that nanoparticles could be modulated to pass through metabolic barriers and specifically targeted to deliver drugs to the required sites without affecting healthy cells and tissues. This makes them a promising therapeutical choice for the treatment of inflammatory diseases in the future

CLAUDIN-3 Protein Expression Relation with Dermatological Diseases: Review Article

Background: When it comes to barrier and pore creation in metazoans, especially vertebrates and tunicates. Claudins are an important family of transmembrane proteins. In epithelia and endothelia's apical junctional complex, chordate claudins are crucial architectural proteins for tight junction strands. Psoriasis patients often have some degree of subclinical intestinal irritation. In gastrointestinal mucosal biopsies, lymphocytic infiltration is found in about 60% of patients. Intestinal absorption is hampered by structural and functional changes in the colon caused by inflammatory cells. Those who have psoriasis have abnormalities in fecal fat excretion, decreased D-xylose absorption, and impaired lactase activity. Objective: To assess the relation between CLAUDIN-3 protein with dermatological diseases. Conclusion: Claudin-3 is a key component of tight junctions, which may serve as marker of gut barrier integrity. Claudin-3 level may be altered in patients with psoriasis

Estimation of nitrogen use efficiency by mango seedlings under nano and convention calcium fertilization using the enriched stable isotope (N-15)

This study aimed to investigate the effect of nano-Ca fertilizer on nitrogen uptake, nitrogen use efficiency and determine the best calcium form and dose for mango.  A pot experiment was conducted using two year old mango seedlings (cv. Zebda). The pots were filled with sandy soil (8 kg per pot) and one seedling was transplanted into each pot. Four treatments including nano-Ca, convention Ca, soil application and foliar application have been formulated. Calcium was applied as CaO for both the convention and nanoforms. The enriched (15NH4)2SO4 was applied at a rate of (5g per pot). Plants were harvested at the end of the fall, spring, and summer growth cycles and dried at 70 oC. The dried plant is used for making fine powder and to determine total nitrogen, calcium, and %15N atom excess. Results of the study revealed that in all growth cycles, the 15N translocation was higher under foliar nano-Ca treatment than under convention Ca at a 100% rate. The highest uptake, translocation, and nitrogen use efficiency were observed at 50% (250 mg. L-1) foliar nano-Ca treatment in all cycles. In the Fall growth cycle, the values for nitrogen fertilizer use efficiency at 50% nano-Ca rate was 81.8%, while it recorded 64.9% for 25% rate and 51.2% for 100% rate.  Calcium concentration, in shoot and roots, was also higher under nano-calcium (for fall cycle = 3.0 for the shoot and 2.8 for root) than the convention calcium (for fall cycle = 2.7% for the shoot and 2.2 for root) for all cycles. The summer growth cycle recorded the highest total biomass under all treatments compared with the fall or spring growth cycles. Allocation of biomass to the shoot was also reported higher under nano-Ca foliar application than that of soil application in all cycles. The best treatment is 50% (250 mg.L-1) foliar nano-Ca as it resulted in the highest N-15 uptake, translocation, and nitrogen use efficiency. Nano calcium proves to be more efficient as fertilizer than conventional calcium

Role of Inflammatory Markers in the Differential Diagnosis of Bleeding in Early Pregnancy

Background: Defective placentation as a cause of many pregnancy-related conditions including abortion and ectopic pregnancy will involve abnormal inflammatory response. Assessment of different inflammatory markers as neutrophillymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) may aid in the differentiation of causes of bleeding in early pregnancy. Objective: To verify the ability of NLR, PLR, and LMR to differentiate cases of miscarriage or ectopic pregnancy from normal pregnancy in patients presenting with bleeding in the first trimester. Patients and Method: A prospective observational study of 150 patients presenting with bleeding in the first trimester were enrolled in the study. After history taking, clinical examination, ultrasound, quantitative beta-human chorionic gonadotropin (B-hCG), or laparoscopy, patients were allocated into three groups: miscarriage group (60 patients), ectopic pregnancy group (30 patients), and control group (60 patients) who continued their pregnancy beyond 20 weeks. For all patients NLR, PLR, and LMR were calculated. Results: NLR was significantly higher and LMR was significantly lower in ectopic pregnancy group when compared to the miscarriage group or the normal pregnancy group. A cutoff level of > 2.7 for NLR and < 3.7 for LMR has a sensitivity of 80% and 70%, and a specificity of 60 % and 80 %, respectively. Conclusion: Utilization of both NLR and LMR will aid in the differentiation of cases of ectopic pregnancy from normal pregnancy or miscarriage with an acceptable sensitivity and specificity

Recent Modalities in Treatment of Atopic Dermatitis: Review Article

Background: Inflammation of the skin marked by itchy, pigmented, dry areas is known as Atopic Dermatitis (AD), also known as Atopic Eczema (AE) or Eczema. Symptoms include red, itchy pimples that leak fluid and crust, scaly or raw skin, or raw or scaly skin. Dermatitis can come in many different forms, such as atopic, contact, or seborrheic. In children, atopic dermatitis is the most prevalent kind of eczema and often occurs in association with other allergic or asthmatic conditions. Eczema is most commonly found on the face, neck, elbows, knees, and toes, among other places. In terms of phototherapy, ultraviolet B phototherapy (280–320 nm) is the "oldest" method that is used in treatment of atopic dermatitis. Platelet rich plasma (PRP) injection utilizes the body's own regenerative mechanisms to help treat disease in the patient. Objective: Determination of the updated treatment modalities in Atopic Dermatitis management. Conclusion: Clearly there remains a need to find more potent topical agents with fewer side effects. The most gratifying advances in AD therapy have come from better understanding of immune and inflammatory mechanisms

Myomectomy for fibroids during cesarean section: A randomized controlled trial

Background: There is a considerable debate about the management of myoma during cesarean section (CS). Recently, several studies indicated the safety and feasibility of undertaking myomectomy during CS.Objectives: To evaluate the safety, accessibility, and short-term morbidity of myomectomy for fibroids during cesarean section.Patients and Methods: This was a randomized controlled trial that included 72 patients who were admitted to the Obstetrics & Gynecology Department, Menoufia University Hospital with uterine fibroids during pregnancy; who were randomly allocated equally into a group of cesarean myomectomy (CM; n=36) and another group of CS only (n=36). The operative events and the outcome were recorded and analyzed.Results: CM group showed a longer duration of surgery and longer hospital stay, higher amount of blood loss, and higher mean pain sores, with a highly statistically significant difference (p = 0.000). No cases in both groups required blood transfusion or ICU admission. No statistically significant differences were noted between both groups as regards the fetal outcome measures (p=0.583 & 0.601).Conclusion: CM is safe and applicable in selected cases without deleterious maternal complications. Special precautions ought to be paid during the procedure, particularly in the intramural type and with large fibroids

Alpha lipoic acid and diabetes mellitus: potential effects on peripheral neuropathy and different metabolic parameters

Introduction: Alpha lipoic acid (ALA) is an antioxidant used in the treatment of neuroinflammation, diabetes and diabetic nephropathy. The current study aiming to gauge the effect of oral ALA on diabetic peripheral neuropathy, glycemic control, LDL-C, and HDL-C. Methods: This is a prospective, interventional study carried out on patients with type 2 diabetes mellitus (DM) who were following at the outpatient internal medicine & diabetes clinics at Benha University Hospital. Treatment with ALA for 3 months was given to patient with diabetic peripheral neuropathy. Data in the form of age, sex, body mass index (BMI), duration & treatment of DM, manifestations of peripheral neuropathy were collected. LDL-C, HDL-C, HbA1c, TSH, ALT, AST were measured before and after intervention. Peripheral neuropathy symptoms, nerve conduction velocities, cardiovascular (CV) tests of autonomic neuropathy, and cross-section area of the posterior tibial nerve were performed before and after treatment intervention. Results: 90 adult diabetic patients were recruited in the study, 42.2% were females and 57.8% were males with a median age of 50–60.3 years (IQR = 52). A statistically significant improvements of neuropathic symptoms, nerve conduction velocity, and cardiovascular autonomic neuropathy were noted after 3 months of administration of ALA (p ˂0.001). However, the cross-section area of the posterior tibial nerve at baseline and after treatment did not change significantly (p value of 0.84). There was a significant improvement in the BMI, HDLC, LDL-C, HbA1c (p ˂ 0.001). Conclusion: Oral treatment with ALA might cause ameliorations of peripheral neuropathy, HbA1c, and LDL-C & HDL-C levels in diabetic patients. Our result failed to proof effect of ALA on nerve cross-section area. The global data encourage further studies with this medication as an ancillary treatment of DM2.Clinical trial registration: It was registered in clinical trial website; ClinicalTrials.gov Identifier(NCT number): NCT04322240

CLOUD POINT EXTRACTION, PRECONCENRATION AND SPECTROPHOTOMETRIC DETERMINATION OF COBALT IN WATER SAMPLES

Objective: A new cloud point extraction (CPE) method was developed for pre concentration of trace cobalt (II) in water samples.Methods: The method is based on the complexation reaction of Co (II) with 2-(benzothiazolyl azo)-4-nitrophenol reagent (BTANP) at pH 7.0 and micelle-mediated extraction using the nonionic surfactant Triton X-114 of the complex.Results: The enriched analyte in the surfactant-rich phase was diluted with methanol and the cobalt content was determined by spectrophotometry at 549 nm. The optimum conditions (e. g. pH, reagent and surfactant concentrations, and temperature and centrifugation times) were evaluated and optimized. The proposed CPE method showed linear calibration within the range 10–300 ng/ml of Co(II) and the limit of detection of the method was 1.5 ng/ml with a pre concentration factor of 50. The relative standard deviation (RSD) was found to be 1.20% (N = 6). The interference effect of some cations and anions was also studied.Conclusion: The proposed method has been successfully applied to the determination of Co(II) in water samples with a recovery from spiked samples in the range of 96.60–98.70%.Â

Post-partum right ovarian vein thrombosis mimicking acute appendicitis: a rare entity

Postpartum ovarian vein thrombosis (OVT) is a rare condition that must be distinguished from other causes of acute abdominal pain because it presents with non-specific, predominantly lower abdominal pain. If the right ovarian vein is involved, pain would be predominantly right-sided and may be missed for acute appendicitis. OVT has been reported to occur in 0.05% to 0.18% in the postpartum period following normal vaginal deliveries, and in up to 2% following caesarean sections. Untreated, postpartum OVT can lead to serious consequences such as sepsis, pulmonary embolism, and even death. We share a case that was admitted to our hospital with symptoms of acute appendicitis that proved later to be due to postpartum ovarian thrombosis. A 28-year-old woman was admitted to our hospital on her 4th postpartum day, following a spontaneous vaginal delivery of a live born full term female baby, complaining of anorexia, nausea, and abdominal pain in her right lower quadrant accompanied by low grade fever. On examination, she appeared ill and had a significant tenderness in her right lower quadrant. An ultrasonography did not reveal any abnormality and did not visualize her appendix. Patient was referred to a consultant gynecologist and was discharged as having no obstetric nor gynaecological cause of her complaint. Patient was admitted to general surgery department where a venography CT of her abdomen confirmed a thrombus in the right ovarian vein with a normal appendix. Blood tests were positive for anticardiolipin. Patient was treated conservatively and responded well to treatment with low molecular weight heparin and antibiotics. OVT is a rare disease, occurring mostly in the postpartum period. Rapid diagnosis is needed to prevent serious consequences and unnecessary surgical procedures, especially when mimicking an acute abdomen