Synthèse de sulfoximines perfluorées hautement fonctionnalisées

International audienc

Benzodithiazoles-sulfoximines : syntheses of new powerful radical fluoroalkylating reagents

International audienc

Palladium versus Nickel dual catalysis: two routes for coupling ortho-iodoperfluorosulfoximines with thiosugars

International audienc

Study of new trifluoromethylation reactions under photoredox catalysis

International audienc

New access to s-perfluoroalkylated sulfoximines and their functionalization

International audienc

High functionalization of S-perfluorinated sulfoximines

International audienc

Radicaux perfluoroalkylés: génération, réactivité et mise en évidence par RPE

International audienc

Perfluoroalkylation of aliphatic thiols in the presence of sodium hydroxymethanesulfinate

Direct perfluoroalkylation of aliphatic thiols was performed in the presence of sodium hydroxymethanesulfinate (Rongalite). Reaction of mercaptoalkanoic esters with trifluoromethyl bromide gave the corresponding trifluoromethylthio ethers. Condensation of alkane dithiols with perfluoroalkyl iodides led mainly to fluorinated dithioethers. These alkylation reactions are interpreted as occurring via in situ formation of dialkyldisulfides

Complete assignment of 1 H and 13C NMR spectra of 1, 2, 4-trisubstituted pyrroles

International audience1,2,4-Trisubstituted pyrroles were synthesized with an original one-pot domino allylic amination/palladium-catalysed Sonogashira cross-coupling and heterocyclisation process. 1H and 13C NMR spectra were assigned for twelve new compounds containing different substituents in positions 1 and 2, and a carboxylic acid or ester group in position 4. Each assignment was based on the combination of one, and two-dimensional experiments (APT, COSY, HMBC)