The Prospective Role of Cognitive Appraisals and Social Support in Predicting Children's Posttraumatic Stress.

Although both social support and cognitive appraisals are strong predictors of children's posttraumatic adjustment, understanding of the interplay between these factors is limited. We assessed whether cognitive appraisals mediated the relationship between social support and symptom development, as predicted by cognitive models of posttraumatic stress disorder (PTSD). Ninety seven children (Mean age = 12.08 years) were assessed at one month and six months following a single incident trauma. We administered self-report measures of cognitive appraisals, social support, and a diagnostic interview for PTSD. Results indicated that cognitive appraisals at one month post-trauma mediated the relationship between social support at one month post-trauma, and PTSD severity at follow-up. Differences in this relationship were observed between child-reported social support and parent-rated ability to provide support. Firm evidence was provided for the application of cognitive models of PTSD to children

Realistic Standard Model Fermion Mass Relations in Generalized Minimal Supergravity (GmSUGRA)

Grand Unified Theories (GUTs) usually predict wrong Standard Model (SM) fermion mass relation m_e/m_{\mu} = m_d/m_s toward low energies. To solve this problem, we consider the Generalized Minimal Supergravity (GmSUGRA) models, which are GUTs with gravity mediated supersymmetry breaking and higher dimensional operators. Introducing non-renormalizable terms in the super- and K\"ahler potentials, we can obtain the correct SM fermion mass relations in the SU(5) model with GUT Higgs fields in the {\bf 24} and {\bf 75} representations, and in the SO(10) model. In the latter case the gauge symmetry is broken down to SU(3)_C X SU(2)_L X SU(2)_R X U(1)_{B-L}, to flipped SU(5)X U(1)_X, or to SU(3)_C X SU(2)_L X U(1)_1 X U(1)_2. Especially, for the first time we generate the realistic SM fermion mass relation in GUTs by considering the high-dimensional operators in the K\"ahler potential.Comment: JHEP style, 29 pages, no figure,references adde

An interferometric gravitational wave detector as a quantum-gravity apparatus

As a consequence of the extreme precision of the measurements it performs, an interferometric gravitational wave detector is a macroscopic apparatus for which quantum effects are not negligible. I observe that this property can be exploited to probe some aspects of the interplay between Quantum Mechanics and Gravity.Comment: LaTex, 7 pages. Version accepted for publication in Nature. Under press embargo until publicatio

Quantum theory's last challenge

Quantum mechanics is now 100 years old and still going strong. Combining general relativity with quantum mechanics is the last hurdle to be overcome in the "quantum revolution".Comment: (9 pages, LaTex) This is the preprint version of an article that appeared in the issue 6813 (volume 408) of Nature, as part of a 3-article celebration of the 100th anniversary of Planck's solution of the black-body-radiation proble

The gravitino coupling to broken gauge theories applied to the MSSM

We consider gravitino couplings in theories with broken gauge symmetries. In particular, we compute the single gravitino production cross section in W+ W- fusion processes. Despite recent claims to the contrary, we show that this process is always subdominant to gluon fusion processes in the high energy limit. The full calculation is performed numerically; however, we give analytic expressions for the cross section in the supersymmetric and electroweak limits. We also confirm these results with the use of the effective theory of goldstino interactions.Comment: 26 pages, 4 figure

A phenomenological description of quantum-gravity-induced space-time noise

I propose a phenomenological description of space-time foam and discuss the experimental limits that are within reach of forthcoming experiments.Comment: 10 pages, LaTex, 1 figure. Short paper, omitting most technical details. More detailed analysis was reported in gr-qc/010400

Explicit solutions for effective four- and five-loop QCD running coupling

We start with the explicit solution, in terms of the Lambert W function, of the renormalization group equation (RGE) for the gauge coupling in the supersymmetric Yang-Mills theory described by the well-known beta function of Novikov et al.(NSVZ). We then construct a class of beta functions for which the RGE can be solved in terms of the Lambert W function. These beta functions are expressed in terms of a function which is a truncated Laurent series in the inverse of the gauge coupling. The parameters in the Laurent series can be adjusted so that the first coefficients of the Taylor expansion of the beta function in the gauge coupling reproduce the four-loop or five-loop QCD (or SQCD) beta function.Comment: 21 pages, 13 figures; in v2, minor changes in the text, two figures added, ref.[3] (2nd entry) is new; version to appear in JHE

Spectrum Generating Conformal and Quasiconformal U-Duality Groups, Supergravity and Spherical Vectors

After reviewing the algebraic structures that underlie the geometries of N=2 Maxwell-Einstein supergravity theories (MESGT) in five and four dimensions with symmetric scalar manifolds, we give a unified realization of their three dimensional U-duality groups as spectrum generating quasiconformal groups. They are F_{4(4)}, E_{6(2)}, E_{7(-5)}, E_{8(-24)} and SO(n+2,4). Our formulation is covariant with respect to U-duality symmetry groups of corresponding five dimensional supergravity theories, which are SL(3,R), SL(3,C), SU*(6), E_{6(6)} and SO(n-1,1)X SO(1,1), respectively. We determine the spherical vectors of quasiconformal realizations of all these groups twisted by a unitary character. We also give their quadratic Casimir operators and determine their values. Our work lays the algebraic groundwork for constructing the unitary representations of these groups induced by their geometric quasiconformal actions, which include the quaternionic discrete series. For rank 2 cases, SU(2,1) and G_{2(2)}, corresponding to simple N=2 supergravity in four and five dimensions, this program was carried out in arXiv:0707.1669. We also discuss the corresponding algebraic structures underlying symmetries of matter coupled N=4 and N>4 supergravity theories. They lead to quasiconformal realizations of split real forms of U-duality groups as a straightforward extension of the quaternionic real forms.Comment: Section 4 is split with the addition of a subsection on quadratic Casimir operators; references added; typos corrected. Latex file; 53 page

Where Do Neurologists Look When Viewing Brain CT Images? An Eye-Tracking Study Involving Stroke Cases

The aim of this study was to investigate where neurologists look when they view brain computed tomography (CT) images and to evaluate how they deploy their visual attention by comparing their gaze distribution with saliency maps. Brain CT images showing cerebrovascular accidents were presented to 12 neurologists and 12 control subjects. The subjects' ocular fixation positions were recorded using an eye-tracking device (Eyelink 1000). Heat maps were created based on the eye-fixation patterns of each group and compared between the two groups. The heat maps revealed that the areas on which control subjects frequently fixated often coincided with areas identified as outstanding in saliency maps, while the areas on which neurologists frequently fixated often did not. Dwell time in regions of interest (ROI) was likewise compared between the two groups, revealing that, although dwell time on large lesions was not different between the two groups, dwell time in clinically important areas with low salience was longer in neurologists than in controls. Therefore it appears that neurologists intentionally scan clinically important areas when reading brain CT images showing cerebrovascular accidents. Both neurologists and control subjects used the “bottom-up salience” form of visual attention, although the neurologists more effectively used the “top-down instruction” form

Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer

The purpose of this study was to determine whether epirubicin, cisplatin and infused 5FU (ECF) improves overall survival (OS) compared to 5FU, etoposide and leucovorin (FELV) in patients with previously untreated advanced biliary cancer in a prospective randomised study. Patients were randomly assigned to receive epirubicin, cisplatin and infused 5FU ECF or bolus 5FU etoposide and leucovorin (FELV). The primary end point was OS with secondary end points of objective response rate (ORR), failure-free survival (FFS), quality of life (QOL) and toxicity. In all, 54 patients were recruited with 27 randomly assigned to each arm. The median OS for ECF was 9.02 months (95% confidence interval (CI): 6.46–11.51) and FELV 12.03 months (95% CI: 9.3–14.7), P=0.2059. Objective response rates were similar for both arms: ECF 19.2% (95% CI: 6.55–39.3); FELV 15% (95% CI: 3.2–37.9), P=0.72. There was significantly increased grade 3/4 neutropenia with FELV vs ECF (53.8 vs 29.5%, respectively, P=0.020). Symptom resolution was impressive for both regimens. This is the largest reported randomised study to date in this setting. ECF did not improve OS compared to FELV, but was associated with less acute toxicity. These data suggest that chemotherapy can prolong OS and achieve good symptomatic relief in advanced biliary cancer