Play in Early Childhood education

The information in this paper was found in books, Murray Sates library website and other online sources. The purpose of this paper is to define play and the many roles and benefits it has for early childhood education. In this paper, it will define play by what many theorists and researchers have defined it by. The history section will be focused on the different theorists and their thoughts and beliefs about play, This paper will also discuss many sub topics to play such as outdoor play, babies and play and learning and play connected. Towards the end of the paper it will discuss the many benefits that play has for children. Also, it discusses the ways that people can advocate for play

Narratives of resistance: (Re) Telling the story of the HIV/AIDS movement – Because the lives and legacies of Black, Indigenous, and People of Colour communities depend on it

Centering the narratives of the intersectional struggles within the HIV movement for Indigenous sovereignty, Black and People of Colour liberation, and LGBTQ rights tirelessly fought for by Black, Indigenous, and People of Colour communities legitimates their lives and legacies within the movement; and the relevance of a focused response to the HIV epidemic that continues to wreak devastation in these communities. The recent political push for a post-HIV era solely centers the realities of middle-class white, gay men and has genocidal implications for Black, Indigenous, and People of Colour communities

The Dwarfs Beyond: The Stellar-to-Halo Mass Relation for a New Sample of Intermediate Redshift Low Mass Galaxies

A number of recent challenges to the standard Lambda-CDM paradigm relate to discrepancies that arise in comparing the abundance and kinematics of local dwarf galaxies with the predictions of numerical simulations. Such arguments rely heavily on the assumption that the local dwarf and satellite galaxies form a representative distribution in terms of their stellar-to-halo mass ratios. To address this question, we present new, deep spectroscopy using DEIMOS on Keck for 82 low mass (10^7-10^9 solar masses) star-forming galaxies at intermediate redshift (z=0.2-1). For 50 percent of these we are able to determine resolved rotation curves using nebular emission lines and thereby construct the stellar mass Tully-Fisher relation to masses as low as 10^7 solar masses. Using scaling relations determined from weak lensing data, we convert this to a stellar-to-halo mass (SHM) relation for comparison with abundance matching predictions. We find a discrepancy between the propagated predictions from simulations compared to our observations, and suggest possible reasons for this as well as future tests that will be more effective.Comment: 11 pages, 7 figures, submitted to ApJ, comments welcom

How do you exercise with epilepsy? Insights into the barriers and adaptations to successfully exercise with epilepsy.

Exercise has been shown to be a physiological and psychological benefit for people with epilepsy (PWE). However, barriers prevent many PWE from exercising safely and confidently. This research explored current perceived barriers to exercise and adaptation techniques used by PWE in order to maintain physical activity levels. Three focus groups (2-3 participants per group) and three semi-structured interviews were conducted (11 participants total). Constructive grounded theory was used to frame the study and analyse the findings, presenting new insight into the motivation, perceived barriers, and adaptation techniques used to exercise. The main motivator to maintain physical activity levels was the benefit of exercise on physical and mental health. This was shown in an increase in mood, higher social interaction, and perceived improvement in overall physical health as a result of exercise. Current barriers to exercise included a fear of injury, lack of social support, and exercise-induced seizures (e.g., through overheating and/or high exercise intensity level). Adaptation techniques used were self-monitoring through the use of technology, reducing exercise frequency and intensity level, and exercising at certain times of the day. The importance of social support was shown to provide increased confidence and positive encouragement to exercise, contrasting with family and friends worrying for his/her safety and medical professionals requesting termination of some physical activities. These findings provide new insight into current adaptation techniques that are used and developed by PWE to overcome common barriers to exercise. These new additions to the literature can lead to further development of such techniques as well as examine current medical professionals' knowledge of the benefits of exercise for PWE

Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC:is there evidence to support a prognostic or diagnostic role?

BACKGROUND: Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk. We aimed to investigate the relationship between these risk factors and Akt phosphorylation, to determine prognostic value. METHOD: VEGF-positive HNSCC biopsies, with known HPV status, were analyzed by immunohistochemistry (IHC) for Akt, phosphorylated at residues S473 and T308. Comparisons between the tissues were carried out using a Mann–Whitney U test. Associations between the variables and continuous immunohistochemical parameters were evaluated with general linear models. Patient characteristics and pAkt IHC score were analyzed for possible association with overall survival by Cox proportional hazard models. RESULTS: Immunohistochemistry revealed that cancer patients had significantly higher levels of pAkt T308 than S473 (P < 0.001). Smoking and alcohol were found to be independent risk factors for Akt phosphorylation at T308 (P = 0.022 and 0.027, respectively). Patients with tumors positive for HPV or pAkt S473 had a poorer prognosis (P = 0.005, and 0.004, respectively). Patients who were heavy drinkers were 49 times more likely to die than non-drinkers (P = 0.003). Patients with low pAkt T308 were more likely to be HPV positive (P = 0.028). Non-drinkers were also found to have lower levels of pAkt T308 and were more likely to have tumors positive for HPV than heavy drinkers (P = 0.044 and 0.007, respectively). CONCLUSION: This study suggests different mechanisms of carcinogenesis are initiated by smoking, alcohol and HPV. Our data propose higher phosphorylation of Akt at T308 as a reliable biomarker for smoking and alcohol induced HNSCC progression and higher phosphorylation of Akt at S473 as a prognostic factor for HNSCC