The K Band Luminosity Functions of Galaxies in High Redshift Clusters

K band luminosity functions (LFs) of three, massive, high redshift clusters of galaxies are presented. The evolution of K*, the characteristic magnitude of the LF, is consistent with purely passive evolution, and a redshift of forma tion z = 1.5-2.Comment: 3 pages, to appear in Proceedings of IAU Colloquium 195 - Outskirts of Galaxy Clusters: intense life in the suburb

Kinetics and Inhibition Studies of the L205R Mutant of cAMP-Dependent Protein Kinase Involved in Cushing’s Syndrome

Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing\u27s syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal adenomas of patients with adrenocorticotropic hormone‐independent Cushing\u27s syndrome. Here, we conducted kinetics and inhibition studies on the L205R‐PKACα mutant. We have found that the L205R mutation affects the kinetics of both Kemptide and ATP as substrates, decreasing the catalytic efficiency (kcat/KM) for each substrate by 12‐fold and 4.5‐fold, respectively. We have also determined the IC50 and Ki for the peptide substrate‐competitive inhibitor PKI(5–24) and the ATP‐competitive inhibitor H89. The L205R mutation had no effect on the potency of H89, but causes a \u3e 250‐fold loss in potency for PKI(5–24). Collectively, these data provide insights for the development of L205R‐PKACα inhibitors as potential therapeutics

Who the hell was that? Stories, bodies and actions in the world

This article explores a two-way relationship between stories and the experiential actions of bodies in the world. Through an autoethnographic approach, the article presents a series of interlinked story fragments in an effort to show and evoke a feel for the ways in which stories, bodies, and actions influence and shape each other over time. It offers some reflections on the experiences the stories portray from the perspective of a social constructionist conception of narrative theory and suggest that while stories exert a powerful influence on the actions of our bodies, our bodies intrude on or ‘talk back’ to this process because bodies have an existence beyond stories

Higher twists in polarized DIS and the size of the constituent quark

The spontaneous breaking of chiral symmetry implies the presence of a short-distance scale in the QCD vacuum, which phenomenologically may be associated with the "size" of the constituent quark, rho ~ 0.3 fm. We discuss the role of this scale in the matrix elements of the twist-4 and 3 quark-gluon operators determining the leading power (1/Q^2-) corrections to the moments of the nucleon spin structure functions. We argue that the flavor-nonsinglet twist-4 matrix element, f_2^{u - d}, has a sizable negative value of the order rho^{-2}, due to the presence of sea quarks with virtualities ~ rho^{-2} in the proton wave function. The twist-3 matrix element, d_2, is not related to the scale rho^{-2}. Our arguments support the results of previous calculations of the matrix elements in the instanton vacuum model. We show that this qualitative picture is in agreement with the phenomenological higher-twist correction extracted from an NLO QCD fit to the world data on g_1^p and g_1^n, which include recent data from the Jefferson Lab Hall A and COMPASS experiments. We comment on the implications of the short-distance scale rho for quark-hadron duality and the x-dependence of higher-twist contributions.Comment: 8 pages, 4 figure

Remarks on a Proposed Super-Kamiokande Test for Quantum Gravity Induced Decoherence Effects

Lisi, Marrone, and Montanino have recently proposed a test for quantum gravity induced decoherence effects in neutrino oscillations observed at Super-Kamiokande. We comment here that their equations have the same qualitative form as the energy conserving objective state vector reduction equations discussed by a number of authors. However, using the Planckian parameter value proposed to explain state vector reduction leads to a neutrino oscillation effect many orders of magnitude smaller than would be detectable at Super-Kamiokande. Similar estimates hold for the Ghirardi, Rimini, and Weber spontaneous localization approach to state vector reduction, and our remarks are relevant as well to proposed $K$ meson and $B$ meson tests of gravity induced decoherence.Comment: 10 pages, plain Tex, no figure

Random Hamiltonian in thermal equilibrium

A framework for the investigation of disordered quantum systems in thermal equilibrium is proposed. The approach is based on a dynamical model--which consists of a combination of a double-bracket gradient flow and a uniform Brownian fluctuation--that `equilibrates' the Hamiltonian into a canonical distribution. The resulting equilibrium state is used to calculate quenched and annealed averages of quantum observables.Comment: 8 pages, 4 figures. To appear in DICE 2008 conference proceeding

Comment On ``Grand Unification and Supersymmetric Threshold"

Barbieri and Hall have argued that threshold effects at the scale of grand-unification wipe out predictions on the SUSY scale, M_S. Using triviality arguments we give upper bounds on ultraheavy particles, while proton stability gives lower bounds on the mass of the higgs color-triplet. We find no useful lower bound on the $\Sigma$ supermultiplet, but if the strong coupling constant is as large as recent experiments suggest, unification in the minimal SUSY SU(5) model requires that the $Sigma$ masses be $\sim 10^{-7}M_V$ and that the color octet and weak triplet be split in mass by a factor of $\sim$100.Comment: 6 pages (revised