Effects of water quality in Bassenthwaite Lake on anglers' catches of salmon and sea-trout in the River Derwent

This is the report on the Effects of Water Quality in the Bassenthwaite Lake on Anglers Catches of Salmon and Sea-trout in the River Derwent April 1993 by the Institute of Freshwater Ecology. An analysis of the catch statistics for salmon and sea-trout in the Rivers Derwent and Cocker was undertaken in relation to available information on the algal water quality in Bassenthwaite Lake to test the hypothesis that poor catch returns were associated with a deterioration of water quality within the lake. Analysis of the catch statistics failed to reveal any correlation between water quality and catch returns for either species of fish and it is concluded that any water deterioration in Bassenthwaite Lake has not caused any major damage to the salmon and sea trout fisheries of the Derwent/Cocker system. This conclusion is supported by the analysis of the Windermere/Leven and Crake system, where no correlation could be found between lake water quality and downstream catches of migratory salmonid fish. However, the possibility still exists and such an effect might be detected by further field work on the macroinvertebrates and on the composition of potential salmonid spawning in the area

Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra PEPA

This paper examines the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11]. Two models of the system are presented, a reagent-centric view and a pathway-centric view. The models capture functionality at the level of subpathway, rather than at a molecular level. Each model affords a different perspective of the pathway and analysis. We demonstrate the two models to be formally equivalent using the timing-aware bisimulation defined over PEPA models and discuss the biological significance

Charged Majoron Emission in Neutrinoless Double Beta Decay

We examine in detail the predictions of the charged majoron model, introduced recently by Burgess and Cline, for 0+ --> 0+ double beta decay transitions. The relevant nuclear matrix elements are evaluated, within the quasiparticle random phase approximation, for 76Ge, 82Se, 100Mo, 128Te and 150Nd nuclei. The calculated transition rates turn out to be much smaller than the experimental upper limits on possible majoron emission, except in a small region of the model's parameter space.Comment: 9 pages, 1 encapsulated postscript figure, uses epsf.tex; reference [15] has been correcte

Mass Dependence of M3Y-Type Interactions and the Effects of Tensor Correlations

The mass dependence of the M3Y-type effective interactions and the effects of tensor correlations are examined. Two-body nuclear matrix elements are obtained by the lowest order constrained variational (LOCV) technique with and without tensor correlations. We have found that the tensor correlations are important especially in the triplet-even (TE) and tensor-even (TNE) channels in order to reproduce the G-matrix elements obtained previously. Then M3Y-type potentials for inelastic scattering are obtained by fitting our two-body matrix elements to those of a sum of Yukawa functions for the mass numbers A=24, A=40 and A=90.Comment: 13 pages, 6 table

Sediment delivery on rill and interrill areas

Equations which relate sediment delivery to a power function of flow rate and slope gradient were evaluated in this study. The data used to parameterize the equations were obtained from sites where crop residues had been removed, and moldboard plowing and disking had occurred. Measurements of sediment delivery resulting from simulated rainfall were obtained from preformed rills and interrill areas. The equations provided reliable sediment delivery estimates for selected soils located throughout the United States. To use the sediment delivery equations, soil-related parameter values must be identified. Multiple regression analyses were performed to relate parameter values used in the equations to selected soil properties. Equations were also developed for estimating rill sediment delivery under rainfall conditions from rill soil loss and discharge data collected without the addition of rainfall. The equations identified in this study, and appropriate soils information, can be used to predict sediment delivery on both rill and interrill areas

Non-invasive methods for the estimation of mPAP in COPD using Cardiovascular Magnetic Resonance Imaging

Purpose Pulmonary hypertension (PH) is associated with a poor outcome in chronic obstructive pulmonary disease (COPD) and is diagnosed invasively. We aimed to assess the diagnostic accuracy and prognostic value of non-invasive cardiovascular magnetic resonance (CMR) models. Methods Patients with COPD and suspected PH, who underwent CMR and right heart catheter (RHC) were identified. Three candidate models were assessed: 1, CMR-RV model, based on right ventricular (RV) mass and interventricular septal angle; 2, CMR PA/RV includes RV mass, septal angle and pulmonary artery (PA) measurements; 3, the Alpha index, based on RV ejection fraction and PA size. Results Of 102 COPD patients, 87 had PH. The CMR-PA/RV model had the strongest diagnostic accuracy (sensitivity 92%, specificity 80%, positive predictive value 96% and negative predictive value 63%, AUC 0.93, p<0.0001). Splitting RHCmPAP, CMR-RV and CMR-PA/RV models by 35mmHg gave a significant difference in survival, with log-rank chi-squared 5.03, 5.47 and 7.10. RV mass and PA relative area change were the independent predictors of mortality at multivariate Cox regression (p=0.002 and 0.030). Conclusion CMR provides diagnostic and prognostic information in PH-COPD. The CMR-PA/RV model is useful for diagnosis, the RV mass index and PA relative area change are useful to assess prognosis. Key Points • Pulmonary hypertension is a marker of poor outcome in COPD. • MRI can predict invasively measured mean pulmonary artery pressure. • Cardiac MRI allows for estimation of survival in COPD. • Cardiac MRI may be useful for follow up or future trials. • MRI is potentially useful to assess pulmonary hypertension in patients with COPD

Dynamic contrast-enhanced magnetic resonance imaging in patients with pulmonary arterial hypertension.

Dynamic contrast-enhanced (DCE) time-resolved magnetic resonance (MR) imaging is a technique whereby the passage of an intravenous contrast bolus can be tracked through the pulmonary vascular system. The aim of this study was to investigate the prognostic significance of DCE-MR pulmonary blood transit times in patients with pulmonary arterial hypertension (PAH). Seventy-nine patients diagnosed with PAH underwent pulmonary DCE imaging at 1.5 T using a time-resolved three-dimensional spoiled gradient echo sequence. The prognostic significance of two DCE parameters, full width at half maximum (FWHM) of the first-pass clearance curve and pulmonary transit time (PTT), along with demographic and invasive catheter measurements, was evaluated by univariate and bivariate Cox proportional hazards regression and Kaplan-Meier analysis. DCE-MR transit times were most closely correlated with cardiac index (CI) and pulmonary vascular resistance index (PVRI) and were both found to be accurate for detecting reduced CI (FWHM area under the curve [AUC] at receiver operating characteristic analysis = 0.91 and PTT AUC = 0.92, respectively) and for detecting elevated PVRI (FWHM AUC = 0.88 and PTT AUC = 0.84, respectively). During the follow-up period, 25 patients died. Patients with longer measurements of FWHM (P = 0.0014) and PTT (P = 0.004) were associated with poor outcome at Kaplan-Meier analysis, and both parameters were strong predictors of adverse outcome from Cox proportional hazards analysis (P = 0.013 and 0.010, respectively). At bivariate analysis, DCE measurements predicted mortality independent of age, gender, and World Health Organization functional class; however, invasive hemodynamic indexes CI, PVRI, and DCE measurements were not independent of one another. In conclusion, DCE-MR transit times predict mortality in patients with PAH and are closely associated with clinical gold standards CI and PVRI

Non equilibrium effects in fragmentation

We study, using molecular dynamics techniques, how boundary conditions affect the process of fragmentation of finite, highly excited, Lennard-Jones systems. We analyze the behavior of the caloric curves (CC), the associated thermal response functions (TRF) and cluster mass distributions for constrained and unconstrained hot drops. It is shown that the resulting CC's for the constrained case differ from the one in the unconstrained case, mainly in the presence of a ``vapor branch''. This branch is absent in the free expanding case even at high energies . This effect is traced to the role played by the collective expansion motion. On the other hand, we found that the recently proposed characteristic features of a first order phase transition taking place in a finite isolated system, i.e. abnormally large kinetic energy fluctuations and a negative branch in the TRF, are present for the constrained (dilute) as well the unconstrained case. The microscopic origin of this behavior is also analyzed.Comment: 21 pages, 11 figure