Investigation of Physicochemical Properties of PVA-GANT Mucoadhesive Hydrogels

The aim of this work was the manufacture and characterisation of novel chemically cross-linked mucoadhesive PVA-GANT hydrogels prepared by using autoclaving. Particularly, the study was focused on the physicochemical and pharmaceutical properties of these hydrogels with regards to potential applications for drug delivery and wound dressing. PVA-GANT hydrogels with different molar ratios and total concentrations of polymers in solution were prepared using a standard sterilisation autoclave. The physico-chemical properties were characterised by various techniques including IR spectroscopy, Texture Analysis and SEM and thermo-analytical techniques (DSC and TGA). Pharmaceutical characteristics were obtained in drug loading/release tests and microbiological assays. The results have shown that the properties of hydrogels (swelling degree, mechanical properties, internal structure, drug loading/release and antimicrobial properties) are very dependent on the polymer composition

Evaluation of water properties in HEA–HEMA hydrogels swollen in aqueous-PEG solutions using thermoanalytical techniques

Hydrogels are polymeric materials used in many pharmaceutical and biomedical applications due to their ability to form 3D hydrophilic polymeric networks, which can absorb large amounts of water. In the present work, polyethylene glycols (PEG) were introduced into the hydrogel liquid phase in order to improve the mechanical properties of hydrogels composed of 2-hydroxyethylacrylate and 2-hydroxyethylmethacrylate (HEA–HEMA) synthesized with different co-monomer compositions and equilibrated in water or in 20 % water–PEG 400 and 600 solutions. The thermoanalytical techniques [differential scanning calorimetry (DSC) and thermogravimetry (TG)] were used to evaluate the amount and properties of free and bound water in HEA–HEMA hydrogels. The internal structure and the mechanical properties of hydrogels were studied using scanning electron microscopy and friability assay. TG “loss-on-drying” experiments were applied to study the water-retention properties of hydrogels, whereas the combination of TG and DSC allowed estimating the total amount of freezable and non-freezing water in hydrogels. The results show that the addition of viscous co-solvent (PEG) to the liquid medium results in significant improvement of the mechanical properties of HEA–HEMA hydrogels and also slightly retards the water loss from the hydrogels. A redistribution of free and bound water in the hydrogels equilibrated in mixed solutions containing 20 vol% of PEGs takes place

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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