1 research outputs found
Farnesides A and B, Sesquiterpenoid Nucleoside Ethers from a Marine-Derived <i>Streptomyces</i> sp., strain CNT-372 from Fiji
Farnesides A and B (<b>1</b>,<b> 2</b>), linear sesquiterpenoids
connected by ether links to a ribose dihydrouracil nucleoside, were
isolated from a marine-derived <i>Streptomyces</i> sp.,
strain CNT-372, grown in saline liquid culture. The structures of
the new compounds were assigned by comprehensive spectroscopic analysis
primarily involving 1D and 2D NMR analysis and by comparison of spectroscopic
data to the recently reported ribose nucleoside JBIR-68 (<b>3</b>). The farnesides are only the second example of this exceedingly
rare class of microbial terpenoid nucleoside metabolites. Farneside
A (<b>1</b>) was found to have modest antimalarial activity
against the parasite <i>Plasmodium falciparum</i>