Establishing an analogue population for the most distant galaxies

Lyman break analogues (LBAs) are local galaxies selected to match a more distant (usually z~3) galaxy population in luminosity, UV-spectral slope and physical characteristics, and so provide an accessible laboratory for exploring their properties. However, as the Lyman break technique is extended to higher redshifts, it has become clear that the Lyman break galaxies (LBGs) at z~3 are more massive, luminous, redder, more extended and at higher metallicities than their z~5 counterparts. Thus extrapolations from the existing LBA samples (which match z=3 properties) have limited value for characterising z>5 galaxies, or inferring properties unobservable at high redshift. We present a new pilot sample of twenty-one compact star forming galaxies in the local (0.05<z<0.25) Universe, which are tuned to match the luminosities and star formation volume densities observed in z>~5 LBGs. Analysis of optical emission line indices suggests that these sources have typical metallicities of a few tenths Solar (again, consistent with the distant population). We also present radio continuum observations of a subset of this sample (13 sources) and determine that their radio fluxes are consistent with those inferred from the ultraviolet, precluding the presence of a heavily obscured AGN or significant dusty star formation.Comment: 13 pages, MNRAS accepte

The Induction of Adenomata in Mouse Lung Homografts by Chemical Carcinogens

Implants of lung from 18-day-old embryo BALB/c mice of an inbred strain were exposed to 3,4-benz(a)pyrene or 1,2,5,6-dibenzanthracene and introduced subcutaneously into 6-week-old mice of the same strain. Lung adenomata developed within 16 weeks

Pulmonary Adenomata Induced by Carcinogen Treatment in Organ Culture. Influence of Increasing Amounts of Carcinogen

Explants of lung from 1 month old inbred BALB/c mice were cultured in vitro for 4 days with 3-methylcholanthrene added to the culture medium at various dose levels. They were subsequently implanted subcutaneously into 6-week-old mice of the same strain

Large Scale Structure traced by Molecular Gas at High Redshift

We present observations of redshifted CO(1-0) and CO(2-1) in a field containing an overdensity of Lyman break galaxies (LBGs) at z=5.12. Our Australia Telescope Compact Array observations were centered between two spectroscopically-confirmed z=5.12 galaxies. We place upper limits on the molecular gas masses in these two galaxies of M(H_2) <1.7 x 10^10 M_sun and <2.9 x 10^9 M_sun (2 sigma), comparable to their stellar masses. We detect an optically-faint line emitter situated between the two LBGs which we identify as warm molecular gas at z=5.1245 +/- 0.0001. This source, detected in the CO(2-1) transition but undetected in CO(1-0), has an integrated line flux of 0.106 +/- 0.012 Jy km/s, yielding an inferred gas mass M(H_2)=(1.9 +/- 0.2) x 10^10 M_sun. Molecular line emitters without detectable counterparts at optical and infrared wavelengths may be crucial tracers of structure and mass at high redshift.Comment: 4 pages, accepted for publication in ApJ Letter

Morphologies and Color Gradients of Luminous Evolved Galaxies at z~1.5

We have examined in detail the morphologies of seven z~1.5 passively evolving luminous red galaxies using high resolution HST NICMOS and ACS imaging data. Almost all of these galaxies appear to be relaxed systems, with smooth morphologies at both rest-frame UV and visible wavelengths. Previous results from spectral synthesis modeling favor a single burst of star formation more than 1 Gyr before the observed epoch. The prevalence of old stellar populations, however, does not correlate exclusively with early-type morphologies as it does in the local universe; the light profiles for some of these galaxies appear to be dominated by massive exponential disks. This evidence for massive old disks, along with the apparent uniformity of stellar age across the disk, suggests formation by a mechanism better described as a form of monolithic collapse than as a hierarchical merger. These galaxies could not have undergone a single major merging event since the bulk of their stars were formed, more than 1 Gyr earlier. There is at least one case, however, that appears to be undergoing a "dry merger", which may be an example of the process that converts these unusual galaxies into the familiar spheroids that dominate galaxies comprising old stellar populations at the present epoch.Comment: 16 pages, 9 figures (8 in color), accepted for publication in Ap

Physical properties of local star-forming analogues toz∼ 5 Lyman break galaxies

Intense, compact, star-forming galaxies are rare in the local Universe but ubiquitous at high redshift. We interpret the 0.1-22 μm spectral energy distributions (SED) of a sample of 180 galaxies at 0.05 < z < 0.25 selected for extremely high surface densities of inferred star formation in the ultraviolet. By comparison with well-established stellar population synthesis models we find that our sample comprises young (∼ 60 - 400 Myrs), moderate mass (∼6 × 109 M⊙) star-forming galaxies with little dust extinction (mean stellar continuum extinction Econt(B − V) ∼ 0.1) and find star formation rates of a few tens of Solar masses per year. We use our inferred masses to determine a mean specific star formation rate for this sample of ∼10−9 yr−1, and compare this to the specific star formation rates in distant Lyman break galaxies (LBGs), and in other low redshift populations. We conclude that our sample's characteristics overlap significantly with those of the z ∼ 5 LBG population, making ours the first local analogue population well tuned to match those high redshift galaxies. We consider implications for the origin and evolution of early galaxies

Radio observations confirm young stellar populations in local analogues to z ~5 Lyman break galaxies

We present radio observations at 1.5 GHz of 32 local objects selected to reproduce the physical properties of z .5 star-forming galaxies. We also report non-detections of five such sources in the sub-millimetre. We find a radio-derived star formation rate which is typically half that derived from Hα emission for the same objects. These observations support previous indications that we are observing galaxies with a young dominant stellar population, which has not yet established a strong supernova-driven synchrotron continuum. We stress caution when applying star formation rate calibrations to stellar populations younger than 100 Myr. We calibrate the conversions for younger galaxies, which are dominated by a thermal radio emission component. We improve the size constraints for these sources, compared to previous unresolved ground-based optical observations. Their physical size limits indicate very high star formation rate surface densities, several orders of magnitude higher than the local galaxy population. In typical nearby galaxies, this would imply the presence of galaxy-wide winds. Given the young stellar populations, it is unclear whether a mechanism exists in our sources that can deposit sufficient kinetic energy into the interstellar medium to drive such outflows

Variations in Duschinsky rotations in m-fluorotoluene and m-chlorotoluene during excitation and ionization

We investigate Duschinsky rotation/mixing between three vibrations for both m-fluorotoluene (mFT) and m-chlorotoluene (mClT), during electronic excitation and ionization. In the case of mFT, we investigate both the S1 → S0 electronic transition and the D0+ ← S1 ionization, by two-dimensional laser-induced fluorescence (2D-LIF) and zero-electron-kinetic energy (ZEKE) spectroscopy, respectively; for mClT, only the D0+ ← S1 ionization was investigated, by ZEKE spectroscopy. The Duschinsky mixings are different in the two molecules, owing to shifts in vibrational wavenumber and variations in the form of the fundamental vibrations between the different electronic states. There is a very unusual behavior for two of the mFT vibrations, where apparently different conclusions for the identity of two S1 vibrations arise from the 2D-LIF and ZEKE spectra. We compare the experimental observations to the calculated Duschinsky matrices, finding that these successfully pick up the key geometric changes associated with each electronic transition and so are successful in qualitatively explaining the vibrational activity in the spectra. Experimental values for a number of vibrations across the S0, S1, and D0+ states are reported and found to compare well to those calculated. Assignments are made for the observed vibration-torsion (“vibtor”) bands, and the effect of vibrational motion on the torsional potential is briefly discussed

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

Asthma is a chronic inflammatory airways disease that usually begins in early life and involves gene-environment interactions. Although most asthma exhibits allergic inflammation, many allergic individuals do not have asthma. Here, we report how the asthma gene A Disintegrin and Metalloprotease (ADAM)33, acts as local tissue susceptibility gene that promotes allergic asthma. We show that enzymatically active soluble (s)ADAM33 is increased in asthmatic airways and plays a role in airway remodeling, independent of inflammation. Furthermore, remodeling and inflammation are both suppressed in Adam33 null mice after allergen challenge. When induced in utero or added ex vivo, sADAM33 causes structural remodeling of the airways, which enhances post-natal airway eosinophilia and bronchial hyperresponsiveness following sub-threshold challenge with an aeroallergen. This substantial gene-environment interaction helps to explain the end-organ expression of allergic asthma in genetically susceptible individuals. Finally, we show that sADAM33-induced airway remodeling is reversible, highlighting the therapeutic potential of targeting ADAM33 in asthma