Parents\u27 Feelings and Perceptions Towards their Child\u27s Speech or Language Disorder

Throughout society, there remains a stigma in regards to a person’s speech and language. While the stereotype that a person with a speech or language disorder may have a lower quality of life shines light on the perceptions of mainstream society, there has been research that provides insight into parent’s feelings. The purpose of this project was to explore the research regarding parents’ feelings and perceptions towards their child’s speech or language disorder by conducting a literature review and a questionnaire that could be used as a measuring tool. The researchers used a questionnaire to focus on two main points: personal feelings parents may have regarding a child’s speech or language disorder and their perceptions on how the child’s speech or language disorder may affect his or her life. It was designed to take approximately 15 to 20 minutes and it included a variety of topics such as social relationships, education, and emotions to be answered on a scale of strongly agree to strongly disagree. This project aims to provide better insight into how to better help parents cope with a child’s speech or language disorder by giving a speech-language pathologist a better idea on how to counsel parents. It could also serve as a pilot study that could lead to future research in parents’ feelings and perceptions towards their child’s speech or language disorder

The Lived Experience of Adolescents Who Engage in Nonsuicidal Self-Injury

The purpose of the current study was to explore the lived experience of adolescents who engage in nonsuicidal self-injury (NSSI). Phenomenological interviews inquired about emotionality, conflict styles, and parental relationships among a clinical population of six adolescents. All participants met criteria for the proposed diagnosis of NSSI found in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (American Psychiatric Association, 2013). Nine central themes emerged as significant: identification with an alternative to the dominant culture, inhibition of affect, difficulty managing conflict, suicidality, negative emotionality, feeling numb, negative internal monologue, self-harm as a temporary coping skill, and maternal conflict. The affect regulation function was clearly supported, as adolescents demonstrated low distress tolerance, poor affect regulation skills, and utilized NSSI to obtain temporary emotional relief. Results indicate that adolescent self-injurers are avoidant, as they suppress both positive and negative emotionality, and actively avoid initiating, managing, or addressing conflict. Findings revealed a need for clinical treatment to address the underlying affective disturbances associated with the behavior

The Lived Experience of Adolescents Who Engage in Nonsuicidal Self-Injury

The purpose of the current study was to explore the lived experience of adolescents who engage in nonsuicidal self-injury (NSSI). Phenomenological interviews inquired about emotionality, conflict styles, and parental relationships among a clinical population of six adolescents. All participants met criteria for the proposed diagnosis of NSSI found in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (American Psychiatric Association, 2013). Nine central themes emerged as significant: identification with an alternative to the dominant culture, inhibition of affect, difficulty managing conflict, suicidality, negative emotionality, feeling numb, negative internal monologue, self-harm as a temporary coping skill, and maternal conflict. The affect regulation function was clearly supported, as adolescents demonstrated low distress tolerance, poor affect regulation skills, and utilized NSSI to obtain temporary emotional relief. Results indicate that adolescent self-injurers are avoidant, as they suppress both positive and negative emotionality, and actively avoid initiating, managing, or addressing conflict. Findings revealed a need for clinical treatment to address the underlying affective disturbances associated with the behavior

The information and learning commons: some reflections

The Information and Learning Commons modes of library organization has become more prevalent over the past few decades and allows academic libraries to provide wider-ranging and more cohesive services to their constituents. Several issues, including relying upon a single, mythical Patron in planning for services; poor organization; a lack of cohesion and centralized leadership; and the digital divide may hinder the effectiveness of the Commons and negatively impact both patrons and staff. If these problems can be surmounted, this model shows great promise for both current and future application in academic libraries

The bZip Dimerization Domain of the Epstein–Barr Virus BZLF1 (Z) Protein Mediates Lymphoid-Specific Negative Regulation

AbstractThe Epstein–Barr virus (EBV) immediate-early (IE) protein, BZLF1 (Z), initiates the switch from latent to lytic infection. Z transactivation of an early viral promoter, BMRF1, is relatively inefficient in lymphoid cells (compared with epithelial cells), unless the other EBV IE protein, BRLF1, is also present. Cellular proteins, including the p65 component of NF-κB, have been shown to interact directly with Zin vitrothrough the bZip dimerization domain and inhibit Z-induced transactivation. Here we precisely define a residue within the bZip dimerization domain of Z (amino acid 200) which is required for interactionin vitrowith the p65 component of NF-κB, but is not essential for Z homodimerization. In lymphoid cells, a Z mutant which has been altered at amino acid 200 (tyrosine to glutamic acid) transactivates both the early BMRF1 promoter and the immediate-early BZLF1 promoter (Zp) four- to fivefold better than wild-type Z. In contrast, mutation of amino acid 200 does not affect Z transactivator function in epithelial cells. The results suggest that Z function is specifically inhibited by a lymphoid-specific protein(s) through amino acid 200 in the bZip dimerization domain. Modulation of Z's activator function may help to regulate the stringency of viral latency in lymphocytes

The Epstein–Barr Virus (EBV) DNA Polymerase Accessory Protein, BMRF1, Activates the Essential Downstream Component of the EBV oriLyt

The EBV DNA polymerase accessory protein, BMRF1, is an essential component of the viral DNA polymerase and is required for lytic EBV replication. In addition to its polymerase accessory protein function, we have recently reported that BMRF1 is a transcriptional activator, inducing expression of the essential oriLyt promoter, BHLF1. Here we have precisely mapped the BMRF1-response element in the BHLF1 promoter. We demonstrate that a region of oriLyt (the "downstream component"), previously shown to be one of two domains absolutely essential for oriLyt replication, is required for BMRF1-induced activation of the BHLF1 promoter. Furthermore, the downstream component of oriLyt is sufficient to confer BMRF1-responsiveness to a heterologous promoter. The downstream component contains Sp1 binding sites, and confers Sp1-responsiveness to a heterologous promoter. A series of plasmids containing various protions of the oriLyt downstream component were constructed and analyzed for their ability to respond to the BMRF1 versus Sp1 transactivators. Although the BMRF1-responsive region of the downstream component overlaps the Sp1-responsive element, certain oriLyt sequences required for maximal BMRF1-responsiveness were not required for maximal Sp1-responsiveness. In particular, a site-directed mutation altering the downstream component sequence GATGG (located from -588 to -592 relative to the BHLF1 transcription initiation site) did not affect Sp1-responsiveness, but reduced BMRF-1-responsiveness by 75% and abolished oriLyt replication. Although BMRF1 possesses nonspecific DNA binding activity, were unable to demonstrate specific BMRF1 binding to the downstream component of oriLyt. Our results suggest that BMRF1-induced activation of the essential downstream component of oriLyt may play an important role in oriLyt replication

Referrals to Cleft Lip and Palate Teams: Practices of School-Based Speech-Language Pathologists

Cleft lip and palate (CLP) has been determined to be the second most common birth defect in the United States, affecting 1 in every 940 births (Parker et al., 2010). The team approach is the accepted best practice for children with CLP (Kummer, 2020) and the school-based Speech-Language Pathologist (SLP) has an important role to play in assessment and intervention of children with repaired CLP, however there is little research to describe their collaboration. This research aimed to explore and describe the referral practices of school-based SLP’s to CLP teams. A survey titled “Referral to Cleft Lip and Palate Teams: Practice of School-Based Speech Language Pathologist’s” was developed and distributed to members of the American Speech-Language Hearing Association’s (ASHA’s) Special Interest Groups (SIGs) 15 and 16 following an in depth literature review on the topic. A total of 57 practicing school-based SLPs acted as respondents. The results of the survey suggested VPD was the main reason for making a referral to a CLP team (89.72%), which validates the response that clients mostly referred had suspected VPD (89.47%). Making a team referral was not common practice, as 58.7% had never made a CLP team referral in the schools. ENTs (51.06%) were the preferred choice of referral in comparison to a CLP team (25.53%). Barriers to making CLP team referrals varied and obtaining permission from the school was experienced by some respondents (36.36%). Respondents made valuable comments which centered on positive experiences with working with CLP teams (11/56). The process of making referrals to CLP teams and collaboration between school-based SLPs and CLP teams needs to be addressed in graduate training and CE. According to Vallino et al., (2019) such communication enhances care, bridges the perceived gap between school-based SLPs and CLP teams, and will ensure that children with CLP and VPD receive the best care possible

The cellular YY1 transcription factor binds a cis-acting, negatively regulating element in the Epstein-Barr virus BRLF1 promoter.

Disruption of Epstein-Barr virus latency is induced by expression of either the BZLF1 (in B cells and epithelial cells) or BRLF1 (in epithelial cells only) immediate-early protein. Regulation of BZLF1 and BRLF1 transcription may therefore modulate the stringency of viral latency. The cellular transcription factor YY1 negatively regulates BZLF1 transcription. Here we show that the BRLF1 promoter (Rp) sequences from -206 to -227 (relative to the mRNA start site) and from -7 to +6 are directly bound by YY1. Mutation of the upstream YY1 binding site increases constitutive Rp activity in epithelial cells and B cells, while mutation of the downstream YY1 binding site does not significantly affect Rp activity. Negative regulation of BZLF1 and BRLF1 transcription by YY1 may act to maintain viral latency