PROGRAM & PROCEEDINGS of the 2022 COLLOQUIUM OF THE STONY BROOK UNIVERSITY INTELLECTUAL PROPERTY PARTNERS Female Perspectives on Entrepreneurship and Research How diverse perspectives inspire creativity, drive innovation, and encourage inclusive economic growth

Diverse and varied perspectives are not only central to our institutional mission, but are essential to our society, as we hope to create a more inclusive, more sustainable and ultimately brighter world. Diverse perspectives and collaboration between different institutions, fields and industries must become the norm. This is the program and proceeding of Stony Brook University\u27s colloquium on female perspectives on entrepreneurship and research and how diverse perspectives inspire creativity, drive innovation, and encourage inclusive economic growth. This was a much-needed discussion in January 2022 that\u27s important for the development of entrepreneurship and research worldwide. At Stony Brook University, the entire research community believes that creating an equitable and integrated work environment is an essential part of the success of its innovation and culture. So, this proceeding provides a transcript of the meaningful moderated discussion between 6 expert panelists about female entrepreneurship and research

Female Perspectives on Entrepreneurship and Research How diverse perspectives inspire creativity, drive innovation, and encourage inclusive economic growth

Diverse and varied perspectives are not only central to our institutional mission, but are essential to our society, as we hope to create a more inclusive, more sustainable and ultimately brighter world. Diverse perspectives and collaboration between different institutions, fields and industries must become the norm. This is the program and proceeding of Stony Brook University\u27s colloquium on female perspectives on entrepreneurship and research and how diverse perspectives inspire creativity, drive innovation, and encourage inclusive economic growth. This was a much-needed discussion in January 2022 that\u27s important for the development of entrepreneurship and research worldwide. At Stony Brook University, the entire research community believes that creating an equitable and integrated work environment is an essential part of the success of its innovation and culture. So, this proceeding provides a transcript of the meaningful moderated discussion between 6 expert panelists about female entrepreneurship and research

Female Perspectives on Entrepreneurship and Research How diverse perspectives inspire creativity, drive innovation, and encourage inclusive economic growth

Diverse and varied perspectives are not only central to our institutional mission, but are essential to our society, as we hope to create a more inclusive, more sustainable and ultimately brighter world. Diverse perspectives and collaboration between different institutions, fields and industries must become the norm. This is the program and proceeding of Stony Brook University\u27s colloquium on female perspectives on entrepreneurship and research and how diverse perspectives inspire creativity, drive innovation, and encourage inclusive economic growth. This was a much-needed discussion in January 2022 that\u27s important for the development of entrepreneurship and research worldwide. At Stony Brook University, the entire research community believes that creating an equitable and integrated work environment is an essential part of the success of its innovation and culture. So, this proceeding provides a transcript of the meaningful moderated discussion between 6 expert panelists about female entrepreneurship and research

HIV Prevention for Intimate Couples: A Relationship-Based Model

HIV prevention programs targeted to heterosexuals have most often been delivered in individual or group modalities that principally focus on women as the agents of change. To date, most HIV risk-reduction interventions are not specifically designed to address issues involving intimate couples or to include both partners. Approaches which take into account relationship dynamics and communication patterns are needed to enable women to initiate or sustain condom use with their main steady partners. In this paper, we present a relationship-based HIV intervention, Project Connect, delivered to 217 African American and Latino heterosexual couples recruited from primary healthcare settings. The paper will first discuss the rationale and the conceptual framework underlying the intervention and then elaborate on the intervention components. Finally, lessons learned in the implementation of the project and implications of Project Connect to future practice and policy making for HIV interventions for heterosexual couples will be discussed

Introduction: Shakespeare's public spheres

Habermas’ sense of a “cultural Public Sphere” is a notoriously complex term and, when applied to Early Modern cultures, needs careful definition. This essay both introduces the variety of methods by which we might approach playtexts with a view to their public – auditory – impact and contributes to a debate about an audience's understanding of Shakespeare's plays. By selecting two words and their spread of use in one play, Twelfth Night, we might appreciate the potential for meaningful ambiguity latent in how we hear the language of live performance. If we search for how certain terms (in this case, the cluster of semes derived from repetitions of “fancy” and “play”), we might find at times incompatible senses, yet we get near to appreciating the range of Early Modern dramatic language

Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that specifically affects motor neurons and leads to a progressive and ultimately fatal loss of function, resulting in death typically within 3 to 5 years of diagnosis. The disease starts with a focal centre of weakness, such as one limb, and appears to spread to other parts of the body. Mutations in superoxide dismutase 1 (SOD1) are known to cause disease and it is generally accepted they lead to pathology not by loss of enzymatic activity but by gain of some unknown toxic function(s). Although different mutations lead to varying tendencies of SOD1 to aggregate, we suggest abnormal proteins share a common misfolding pathway that leads to the formation of amyloid fibrils.Methodology/Principal Findings: Here we demonstrate that misfolding of superoxide dismutase 1 leads to the formation of amyloid fibrils associated with seeding activity, which can accelerate the formation of new fibrils in an autocatalytic cascade. The time limiting event is nucleation to form a stable protein "seed" before a rapid linear polymerisation results in amyloid fibrils analogous to other protein misfolding disorders. This phenomenon was not confined to fibrils of recombinant protein as here we show, for the first time, that spinal cord homogenates obtained from a transgenic mouse model that overexpresses mutant human superoxide dismutase 1 (the TgSOD1(G93A) mouse) also contain amyloid seeds that accelerate the formation of new fibrils in both wildtype and mutant SOD1 protein in vitro.Conclusions/Significance: These findings provide new insights into ALS disease mechanism and in particular a mechanism that could account for the spread of pathology throughout the nervous system. This model of disease spread, which has analogies to other protein misfolding disorders such as prion disease, also suggests it may be possible to design assays for therapeutics that can inhibit fibril propagation and hence, possibly, disease progression

Analysis of Playground Equipment at Muskegon Public Schools: A Needs Assessment

A local school district, Muskegon Public Schools, is restructuring due to budget constraints. Therapists at Muskegon Public Schools were concerned about the safety and accessibility of the current playgrounds. The purpose of this needs assessment was to determine if any of Muskegon Public Schools’ playgrounds met the students’ safety and accessibility needs. To determine this, the researchers created a checklist using the Consumer Product Safety Commission’s Handbook on Public Playground Safety (1997) and the U.S. Access Board Summary of Accessibility Guidelines for Play Areas (2005). The checklist was then used to assess all nine Muskegon Public School playgrounds. None of the Muskegon Public School playgrounds met all the safety and accessibility requirements. A need exists to update the Muskegon Public School playgrounds to meet the current safety and accessibility requirements. Doing this will not only improve the safety of the playgrounds, but will promote an inclusive natural play environment for all Muskegon Public School students