1 research outputs found
MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from <i>Micromonospora</i> sp. CA-256353
A potent antiplasmodial polycyclic
xanthone, MDN-0185 (<b>1</b>), was isolated from an unidentified
species of the genus <i>Micromonospora</i>. The planar structure
of <b>1</b> was
established as a seven-ring polycyclic xanthone with partial structures
very similar to two known natural products, namely, xantholipin and
Sch 54445. Using ROESY correlations, the relative stereochemistry
of the two independent stereoclusters of compound <b>1</b> could
be determined. Mosher analysis and comparison of the specific rotation
of compound <b>1</b> with that of xantholipin allowed the determination
of its absolute configuration. Compound <b>1</b> exhibited an
IC<sub>50</sub> of 9 nM against <i>Plasmodium falciparum</i> 3D7 parasites