Baseline Characteristics of patients.

<p>Data are n (%) unless otherwise specified</p><p>* T test for continuous variable and chi-square test or Fisher’s Exact Test for qualitative variables</p><p>Significance level set to 0.01 according to Bonferroni adjustment</p><p>Baseline Characteristics of patients.</p

Time to a five-point definitive deterioration in Health related Quality of Life score or death: (A) Physical Well-Being dimension (PWB); (B) Emotional Well-Being dimension (EWB); (C) Social Well-Being dimension (SWB); (D) Functional Well-Being dimension (FWB); (E) Lung Cancer Subscale (LCS).

<p>Arm 1: combination therapy arm; Arm 2: control arm.</p

CONSORT Flow chart showing patients randomised in each group and the number of patients answering FACT-L questionnaire at baseline and follow-up.

<p>Patients still in the study time of the questionnaire completion.</p

Univariate and multivariate Cox analyses for a 5-point definitive deterioration in Health Related Quality of Life scores or death.

<p>PWB: Physical Well-Being dimension; SWB: Social Well-Being; EWB: Emotional Well-Being, FWB: Functional Well-Being; LCS: Lung Cancer Subscale, aNK cells: activated Natural Killer cells.</p><p>¹ variable forced in the multivariate analysis</p><p>² continuous variable</p><p>*: interaction</p><p>Univariate and multivariate Cox analyses for a 5-point definitive deterioration in Health Related Quality of Life scores or death.</p

Results of the Kaplan-Meier estimation of the time until definitive deterioration curves according the level of activated Natural Killer (aNK) cells.

<p>PWB: Physical Well-Being dimension; SWB: Social Well-Being; EWB: Emotional Well-Being, FWB: Functional Well-Being; LCS: Lung Cancer Subscale</p><p>Significance level set to 0.01 according to Bonferroni adjustment</p><p>Results of the Kaplan-Meier estimation of the time until definitive deterioration curves according the level of activated Natural Killer (aNK) cells.</p

Health Related Quality of Life at baseline according to type of treatment allocated by randomization.

<p>CI: confidence interval</p><p>PWB: Physical Well-Being dimension; SWB: Social Well-Being; EWB: Emotional Well-Being, FWB: Functional Well-Being; LCS: Lung Cancer Subscale; TOI: Trial Outcome Index</p><p>Significance level set to 0.01 according to Bonferroni adjustment</p><p>*: Mann-Whitney test</p><p>Health Related Quality of Life at baseline according to type of treatment allocated by randomization.</p

Exposure to livestock in the study population.

<p>Case (P-ADC) and control (non-P-ADC) groups were compared using univariate analysis with the Chi-2 test.</p

Factors independently associated with pneumonic-type lung adenocarcinoma.

<p>Multivariate analysis was performed using log regression model including significant variables at univariate analysis with <i>p</i><0.15.</p><p>CI: Confidence Interval.</p