Recognition of Face Familiarity in Patient GN and in the Twelve Age-, Gender- and Education-matched Controls.

<p>Recognition of Face Familiarity in Patient GN and in the Twelve Age-, Gender- and Education-matched Controls.</p

Anatomical MRI and SPECT of Patient’s GN Brain.

<p>(A) T1-weighted MRI transversal and coronal images showing atrophy in the left temporal lobe (white circles). (B) SPECT transversal and coronal images showing hypoperfusion in the left tempo-parietal region (white circles).</p

Patient GN’s Neuropsychological Assessment.

<p>^aAll scores are corrected for age and education.</p><p>^bMMSE = Mini Mental State Evaluation.</p><p>^cFAB = Frontal Assessment Battery.</p><p>* = Score under normal limits.</p><p>Patient GN’s Neuropsychological Assessment.</p

Brain areas significantly activated by the presentation of faces (known and unknown faces pooled together > baseline activity).

<p>(A) Activations in the left and right FFA. (B) Activations in the left and right OFA. (C) Activation in the right pSTS. (D) Activation in the PCUN/pCING.</p

Areas Activated in Patient GN for HFF (unknown faces wrongly recognized as familiar > unknown faces correctly recognized as unfamiliar).

<p>Areas Activated in Patient GN for HFF (unknown faces wrongly recognized as familiar > unknown faces correctly recognized as unfamiliar).</p

Sulcal Depth of Patient’s GN Brain.

<p>(A). Three-dimensional reconstruction of the sulcal depth in GN’s brain, from surface and shallow depth values (green/yellow) to deep values (orange/red). Note the deepening and widening of the temporal sulci in the left compared to right hemisphere as outlined by expanded red areas in lateral sulcus and in the STS.</p

Sulcal Depth Values and Signal Detection Response Parameters.

<p>(A) Sulcal depth values for the lateral sulcus, STS and the anterior part of the ITS in the left (LH) and right hemisphere (RH) of patient GN and of the twelve age-, gender, and education-matched controls. (B) Signal detection parameters in patient GN (red lines) and averaged parameters in the twelve controls (black lines). High discrimination sensitivity between familiar and unfamiliar faces (<i>d</i>_<i>a</i>) is graphically represented by reduced overlapping between signal distributions (familiarity) (continuous lines) and noise distributions (unfamiliarity) (dashed lines). Response bias (<i>c</i>_<i>a</i>) is represented by the vertical lines, with negative values indicating a loose response criterion (i.e., a tendency to favour familiarity responses).</p

Neurofunctional Signature of Correct Familiarity and of Hyperfamiliarity for Faces.

<p>(A). Neurofunctional signature of correct face familiarity recognition displaying highly significant activations in the right pSTS/TPJ and in the precuneus bilaterally (known faces correctly recognized as familiar > unknown faces correctly recognized as unfamiliar). (B). Neurofunctional signature of HFF displaying highly significant activations in the right medial and lateral inferior temporal cortex, including the parahippocampal and the fusiform gyrus (unknown faces wrongly recognized as familiar > unknown faces correctly recognized as unfamiliar).</p