Ultrasound image of a left tubal ectopic at 6+1 weeks gestation.

<p>A hyperechoic mass is seen adjacent to the left ovary.</p

β hCG clearance curves in women with an ectopic pregnancy managed successfully expectantly in whom the β hCG declined steadily from the initial measurement.

<p>β hCG clearance curves in women with an ectopic pregnancy managed successfully expectantly in whom the β hCG declined steadily from the initial measurement.</p

Additional file 2: Figure S1. of PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression

Example of subclonal loss calculation using SNP array. Figure S2. Pure c-LCIS showing anueploidy and chromothripsis. Figure S3. Proportion of SCNA breakpoints in different subtypes of lobular cancer. (PDF 2813 kb

Additional file 1: Table S1a. of PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression

Clinico-pathological features of the discovery set - pure LCIS. Table S1b. Clinico-pathological features of the discovery set - inv-LCIS and ILC. Table S2a. Validation set: characteristics of the eight pure LCIS tumours that recurred. Table S2b. Validation set: characteristics of pure LCIS tumours that did not recur. Table S3. Common regions of gain /loss <10 Mb in size in classic lobular subtypes. Table S4. Regions of amplification occurring in more than one sample. Table S5a. Somatic mutations identified by whole exome sequencing in both the LCIS and ILC components in a single paired case. Table S5b. Somatic mutations identified by whole exome sequencing in ILC but not the LCIS component in a single paired case. Table S5c. Somatic mutations identified by whole exome sequencing in LCIS but not the ILC component in a single paired case. (DOCX 46 kb

SNPs associated with ILC (P<5×10⁻⁸) or LCIS (P<0.05) in a pooled lobular analysis (GLACIER and BCAC).

<p>SNPs associated with ILC (P<5×10⁻⁸) or LCIS (P<0.05) in a pooled lobular analysis (GLACIER and BCAC).</p

rs11977670, chromosome 7:139942304 G>A, and association ILC in populations of European ancestry.

<p>rs11977670, chromosome 7:139942304 G>A, and association ILC in populations of European ancestry.</p

Forest plot for rs11977670.

<p>Forest plot for rs11977670.</p

SNPs showing differential lobular and ductal associations with breast cancer risk in BCAC subjects (ER+ tumours only).

<p>SNPs showing differential lobular and ductal associations with breast cancer risk in BCAC subjects (ER+ tumours only).</p

Association with risk of breast cancer for rs11977670 stratified by breast cancer tumour subtypes (Pooled analysis, BCAC, GLACIER, UK PHASE II).

<p>Association with risk of breast cancer for rs11977670 stratified by breast cancer tumour subtypes (Pooled analysis, BCAC, GLACIER, UK PHASE II).</p

Lobular cancer study design.

<p>Lobular cancer study design.</p