Examination of Parent's Views about their 60-77 Months Old Children's Maturity of Primary School

AbstractThe concept of school readiness typically refers to the child's attainment of a certain set of emotional, behavioral and cognitive skills needed to learn, work and function successfully in school. Unfortunately, the common philosophy of “ready for school” can be understood by parents and caregivers as children's readiness for the expectations of school (Marquez, 2006). In a more constructive way school readiness concept has many aspects, for example; while attending to a school, children must cope with many new demands; they must meet new academic challenges, learn new school and teacher expectations, and gain acceptance into a new peer group. In the entrance to a school, chronological age is an important factor, but also factors like; gender, previous experience, social skills, intellegence, general health and family composition, well- being, and socioeconomic status play important role. In Turkey obligation to attend primary school age was 6-7 years old. In 2012-2013 educational year, Turkish Ministry of Education changed the compulsory education period to twelve years and the attendence of compulsory education period was changed to 5-6 years old. The aim of the study is to examine parent's views about their children's readiness and maturity attending to primary school. 60-80 months old of children attending four different primary schools took part in the study. An inquiry consisting of questions about children's basic developmental areas, academic skills and school maturity was prepared for the study. The inquiry was applied to voluntary parents. The view of parents were examined according to children's age. No significant differences were found between older and younger children's parents views

Preschooler's Views About Gender Related Games and Toys

AbstractThis study aims to investigate views of preschooler's on gender related games and toys. Sixty children (29 girls; 31 boys) attending two different preschools took part in the study. Before the study, two characters –one of them was girl and the other was boy- were created and preschoolers were introduced to both of them. This study were carried out by placing these characters respectively on the drawings on acetate sheets. At the first stage, drawings of a girl and a boy accepting a gift package from an adult were shown to children. After showing each drawing, children's views about what could be in the gift package, were asked. At the second stage of the study, drawings of two girls, two boys, a girl and a boy at home, class and playground were presented and children were asked about games that children in the drawings could play together. In this study, role of gender in childr en's views of games and toys were investigated in terms of age and sex

Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol

Mannich bases of thymol were synthesized. The aminomethylation reaction was realised in the ortho position of the phenol for compounds 2 (dipropylamine), 3 (benzylamine), and 4 (dibenzylamine) while it was from para position for 1 (dimethylamine), 5 (piperidine), 6 (morpholine) and 7 (N-methylpiperazine). The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the compounds were asssessed against hCA I and hCA II. All compounds moderately inhibited hCA I and hCA II. The cytotoxicity of the compounds against four human oral squamous cell carcinoma cell lines were compared those against three normal oral cells. Tumor specificity values were about 2 or slightly more for the compounds 2, 3, 4, 5 and 6. Compound 2 showed cytostatic activity against OSCC cell lines at 16 to 32-fold lower concentrations as compared with normal cells. This suggests that compound 2 can be considered as cytotoxicity enhancing drug candidate for further investigations

Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones

A series of Mannich bases having piperidine moiety were reacted with 2-mercaptoethanol, leading to 1-aryl-3-piperidine-4-yl-1-propanone hydrochlorides. The cytotoxicity and carbonic anhydrase inhibitory activities of these new compounds were evaluated. Among the compounds, only one derivative, nitro substituent bearing EU9, showed an effective cytotoxicity, although weak tumor specificity against human oral malignant versus nonmalignant cells. The compound induced apoptosis in HSC-2 oral squamous cell carcinoma cells, but not in human gingival fibroblast. Chemical modifications of this lead are thus necessary to further investigate it as a drug candidate and to obtain compounds with a better activity profile

Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase

A series of phenols incorporating tertiary amine and trans-pyridylethenyl-carbonyl moieties were assayed as inhibitors of the beta-carbonic anhydrase (CA, EC 4.2.1.1) from Saccharomyces cerevisiae, ScCA. One of these compounds was a low nanomolar ScCA inhibitor, whereas the remaining ones inhibited the enzyme with K(I)s in the range of 23.5-95.4 nM. The off-target human (h) isoforms hCA I and hCA II were much less inhibited by these phenols, with K(I)s in the range of 0.78-23.5 mu M (hCA I) and 10.8-52.4 mu M (hCA II). The model organism S. cerevisiae and this particular enzyme may be useful for detecting antifungals with a novel mechanism of action compared to the classical azole drugs to which significant drug resistance emerged

Parent s’ Attitude Towards Their Children Before and After Parental Education

AbstractReseach about early childhood development concludes that parents, especially mothers play crucial role in young children's li fe therefore parental education is important for the healthy development of children. This study aims to investigate parental attitude and perception towards their children before and after parental education. 1 8 mothers and 8 fathers of children 3-6 ages with participated in the study. These parents were given education about child development and education by researchers during 10 weeks. The Parental Attitude Research Instrument (PARI) was used as a tool for evaluation of parent attitudes before and after the education. Also an inquiry was administered to parents before and after the study.Data were evaluated according to gender. Findings of the study concludes some important implications for parental education programs

New hematological parameters as early diagnosis and prognostic markers in critically patients

INTRODUCTION: Nucleated red blood cells and immature granulocytes are not normally detected in the blood of healthy adults. We aimed to investigate the effect of nucleated red blood cells and immature granulocytes on mortality in order to identify critically ill patients who were admitted to the emergency department, at high risk of death, and who was not traumatic.MATERIAL AND METHODS: This study was performed retrospectively in the emergency department of a tertiary education and research hospital between January 2021 and June 2021. All patients who died out of trauma and patients who were discharged from the emergency department on the same day were included. Nucleated red blood cells and immature granulocytes parameters were compared between the two groups. The primary outcome was all-cause death in the emergency department.RESULTS: Of the 188 patients included in the study, 129 (68.6%) were male. Nucleated red blood cells (1.88 ± 6.9/μL; 0.02 ± 0.08), % immature granulocytes (2.91 ± 3.04/μL; 0.58 ± 1.63) and immature red blood cells in deceased patients’ granulocyte count (0.38 ± 0.46/μL; 0.04 ± 0.04) was significantly more significant than the control group (p < 0.001). When the area under the curve was examined, the highest value was found in nucleated red blood cells (Area under the curve = 0.920, p < 0.001). In multivariate regression analysis, high nucleated red blood cells, immature granulocyte count, and white blood cell levels were associated with all-cause mortality in the emergency department.CONCLUSIONS: High nucleated red blood cells and immature granulocyte levels may be associated with increased mortality during admission to the emergency department

Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae

A series of phenols incorporating tertiary amine and trans-pyridylethenyl-carbonyl moieties were assayed as inhibitors of the beta-carbonic anhydrase (CA, EC 4.2.1.1) from Saccharomyces cerevisiae, ScCA. One of these compounds was a low nanomolar ScCA inhibitor, whereas the remaining ones inhibited the enzyme with K(I)s in the range of 23.5-95.4 nM. The off-target human (h) isoforms hCA I and hCA II were much less inhibited by these phenols, with K(I)s in the range of 0.78-23.5 mu M (hCA I) and 10.8-52.4 mu M (hCA II). The model organism S. cerevisiae and this particular enzyme may be useful for detecting antifungals with a novel mechanism of action compared to the classical azole drugs to which significant drug resistance emerged