3 research outputs found
Preparation and Evaluation of Orodispersible Tablets Containing <i>Hydroxylbutyl-β-Cyclodextrin-Simvastatin</i> Solid Dispersion
Purpose: To formulate simvastatin orodispersible tablets with high
dissolution rate and enhanced bioavailability. Methods: Simvastatin
solid dispersions in β- cyclodextrin,
hydroxylpropyl-β-cyclodextrin, and
hydroxylbutyl-β-cyclodextrin were prepared in different drug:
polymer ratios by kneading and solvent evaporation methods.
Compatibility was investigated by Differential scanning calorimetry
(DSC) and Fourier transform infrared spectroscopy (FTIR) Based on the
results of solubility studies, the most suitable solid dispersion was
selected and formulated into orodispersible tablets using Emcosoy and
K-polacrillin as superdisintegrants, and mannitol and Pullulan as
diluents. The tablets were evaluated for wetting and disintegration
times, water absorption, and in vtro dissolution. Results: Increase in
drug solubility was dependent on polymer type, concentration and
preparation method. Simvastatin-hydroxylbutyl-β-cyclodextrin solid
dispersion mixture prepared in 1:2 drug: polymer ratio by solvent
evaporation method had a higher solubility than other dispersions. DSC
and FTIR indicated the formation of solid dispersion without chemical
interaction between simvastatin and polymer. Orodispersible tablet
prepared with Emcosoy and Pullulan showed least wetting and
disintegration times (20 and 35 s, respectively), fastest water
sorption rate, and the highest dissolution rate (100 % after 20 min).
Conclusion: Orodispersible tablets prepared with Emcosoy as
superdisintegratnt and Pullulan as diluents and containig simvastatin
solid dispersion in hydroxylbutyl-β-cyclodextrin provides optimum
water solubility and hence, drug bioavailability
Preparation and Evaluation of Orodispersible Tablets Containing Hydroxylbutyl-β-Cyclodextrin-Simvastatin Solid Dispersion
Purpose: To formulate simvastatin orodispersible tablets with high
dissolution rate and enhanced bioavailability. Methods: Simvastatin
solid dispersions in β- cyclodextrin,
hydroxylpropyl-β-cyclodextrin, and
hydroxylbutyl-β-cyclodextrin were prepared in different drug:
polymer ratios by kneading and solvent evaporation methods.
Compatibility was investigated by Differential scanning calorimetry
(DSC) and Fourier transform infrared spectroscopy (FTIR) Based on the
results of solubility studies, the most suitable solid dispersion was
selected and formulated into orodispersible tablets using Emcosoy and
K-polacrillin as superdisintegrants, and mannitol and Pullulan as
diluents. The tablets were evaluated for wetting and disintegration
times, water absorption, and in vtro dissolution. Results: Increase in
drug solubility was dependent on polymer type, concentration and
preparation method. Simvastatin-hydroxylbutyl-β-cyclodextrin solid
dispersion mixture prepared in 1:2 drug: polymer ratio by solvent
evaporation method had a higher solubility than other dispersions. DSC
and FTIR indicated the formation of solid dispersion without chemical
interaction between simvastatin and polymer. Orodispersible tablet
prepared with Emcosoy and Pullulan showed least wetting and
disintegration times (20 and 35 s, respectively), fastest water
sorption rate, and the highest dissolution rate (100 % after 20 min).
Conclusion: Orodispersible tablets prepared with Emcosoy as
superdisintegratnt and Pullulan as diluents and containig simvastatin
solid dispersion in hydroxylbutyl-β-cyclodextrin provides optimum
water solubility and hence, drug bioavailability