trans-Tetra­aqua­bis{(E)-2-cyano-1-[(ethoxy­carbon­yl)methyl­sulfan­yl]-2-(1-naphthyl­amino­carbon­yl)ethene-1-thiol­ato}calcium(II) diethyl ether disolvate

In the title compound, [Ca(C18H15N2O3S2)(H2O)4]·2C4H10O, the Ca atom, which lies on an inversion centre, is coordinated octa­hedrally by four water mol­ecules and two anions of the ketene dithio­acetal, the donor atoms of which are the amidic carbonyl O atoms. The central backbone of the ligands (excluding the naphthalene and oxoethyl groups) is essentially planar (r.m.s. deviation 0.035 Å). Intra­molecular hydrogen bonds are observed from the NH group to the formally ‘thiol­ate’ S atom and from one coordinated water to the nitrile group and to the ether O atom. Inter­molecular hydrogen bonds from the second independent water mol­ecule to the thiol­ate S atom and the side-chain oxo group connect the mol­ecules in chains parallel to the a axis

Crystal structure of N'-[2-(benzo[d]thia-zol-2-yl)acet-yl]benzohydrazide, an achiral compound crystallizing in space group P1 with Z = 1.

In the molecule of the title compound, C16H13N3O2S, one hydrazinic nitrogen atom is essentially planar, but the other is slightly pyramidalized. The torsion angle about the hydrazinic bond is 66.44 (15)°. Both hydrazinic hydrogen atoms lie anti-periplanar to the oxygen of the adjacent carbonyl group. The mol-ecular packing is a layer structure determined by two classical hydrogen bonds, N-H⋯O=C and N-H⋯Nthia-zole. The space group is P1 with Z = 1, which is unusual for an achiral organic compound

Unexpected products of the reaction of cyanoacetylhydrazones of aryl/heteryl ketones with hydrazine: a new route to aryl/heteryl hydrazones, x-ray structure, and in vitro anti-proliferative activity against nci 60-cell line panel

A new unexpected synthetic non-catalytic method for the synthesis of novel heteryl hydrazones for base-modification of nucleoside analogs has been developed. Characterizations of the products have been performed using NMR spectroscopy and single crystal x-ray diffraction analysis. Further in vitro anti-proliferative potency of the compounds against NCI 60 cell lines has been estimated. The results indicate anti-cancer activity by the compounds against several of the cancer cell lines

Crystal structure of 2-cyano-3,3-bis(ethylsulfanyl)-N-o-tolylacrylamide

In the mol­ecule of the title compound, C15H18N2OS2, the central S2C=C(CN)C moiety is planar (r.m.s. deviation = 0.029 Å). The C=O and C—CN groups are trans to each other across their common C—C bond. In the crystal, one classical and two `weak' hydrogen bonds combine with borderline N⋯N and S⋯S contacts to form layers parallel to (10-2). One ethyl group is disordered over two positions with relative occupancy 0.721/0.279 (7)

Crystal structure of 4,6-di­methyl-2-{[3,4,5-trihy­dr­oxy-6-(hy­dr­oxy­meth­yl)tetra­hydro-2H-pyran-2-yl]sulfan­yl}nicotino­nitrile

In the title compound, C14H18N2O5S, the C—S bond lengths are unequal, with S—Cglucose = 1.8016 (15) Å and S—Cpyrid­yl = 1.7723 (13) Å. The hydro­philic glucose residues lie in the regions z ≃ 0.25 and 0.75. Four classical hydrogen bonds link the mol­ecules to form layers parallel to the ab plane, from which the pyridyl rings project; pyridyl ring stacking parallel to the a axis links adjacent layers

Crystal structure of N′-[2-(benzo[d]thia­zol-2-yl)acet­yl]-4-methyl­benzene­sulfono­hydrazide

In the title compound, C16H15N3O3S2, the hydrazide N atom bonded to the C=O group is planar, whereas that bonded to the SO2 group is pyramidally coordinated. The inter­planar angle between the ring systems is 40.71 (3)°. Mol­ecules are connected into ribbons parallel to the b axis by two classical hydrogen bonds N—H⋯O=C and N—H⋯Nthia­zole

Crystal structure of potassium [4-amino-5-(benzo[d]thia-zol-2-yl)-6-(methyl-sulfan-yl)pyrimidin-2-yl](phenyl-sulfon-yl)aza-nide di-methyl-formamide monosolvate hemihydrate

The title compound, K+·C18H14N5O2S3 -·C3H7NO·0.5H2O, was obtained in a reaction designed to deliver a neutral 2-pyrimidylbenzo-thia-zole. The anion is deprotonated at the sulfonamide nitro-gen. The asymmetric unit of the title compound contains two potassium cations, two anions, two mol-ecules of DMF and one of water. The anions display some conformational differences but each contains an intra-molecular N-H⋯Nbenzo-thia-zole hydrogen bond. The potassium ions both display a highly irregular six-coordination, different for each potassium ion. The anions, together with the DMF and water mol-ecules, are linked by four classical hydrogen bonds to form chains parallel to the b-axis direction