Accurate noninvasive estimation of pulmonary vascular resistance by Doppler echocardiography in patients with chronic heart failure

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Role of oxidative and nitrosative stress biomarkers in chronic heart failure

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10th International Symposium on Hysteresis Modeling and Micromagnetics (HMM 2015)

This issue is concerned with the proceedings of the 10th International Symposium on Hysteresis Modeling and Micromagnetics (HMM 2015

Determination of the acceptable MPEG-4 quality for clinical real-time tele-echocardiography services

The characteristics of Moving Picture experts Group (MPEG-4) video compression, in particular its adaptability to narrowband channels and the elevated degree of compression obtainable, make it of interest for services of telemedicine that require instantaneous video transmission and interpretation. In this study we faced the problem of the minimum quality of service (QoS) in specific applications of tele-echocardiography (T-E). In the specifics we evaluated the clinical adequacy of MpEG-4 compression in the real time transmission of echocardiographic studies. Forty echocardiographic examinations consisting of standard projections of patients affected by ischemic heart disease were submitted to two observers expert in echocardiography, who made 4 separate evaluations as follows: 2 on the same equipment on which the original studies were performed; 1 after online MpEG-4 codification of the studies at 256 kb/s; 1 after online MpEG-4 codification of the studies at 128 kb/s. For each evaluation, the following data were collected: subjective opinion on the overall visual quality of the images; estimate of ejection fraction and level of impairment; wall Motion Score Index and percentage of asynergy; mitral failure. The results: 1) the subjective quality of the echocardiographic images was the same as that perceived in the video at Mpeg4/256 kb/s compression level while it was lower, as expected, in the video Mpeg4/128 kb/s; 2) the quality degradation did not produce a statistically significant difference in the evaluation of left ventricular function and regional wall motion impairments. these results confirm the feasibility of MpEG-4 compression for the transmission of echocardiographic studies for use in telemedicine and suggest that it is not necessary to seek transmission speeds higher than 256 kb/s for the semiquantitative reading of left venticular kinetics

Impact of Galectin-3 Circulating Levels on Frailty in Elderly Patients with Systolic Heart Failure

Background: Heart Failure (HF), a leading cause of morbidity and mortality, represents a relevant trigger for the development of frailty in the elderly. Inflammation has been reported to play an important role in HF and frailty pathophysiology. Galectin-3 (Gal-3), whose levels increase with aging, exerts a relevant activity in the processes of cardiac inflammation and fibrosis. The aim of the present study was to investigate the potential of Galectin-3 to serve as a biomarker of frailty in HF patients. Methods: 128 consecutive patients aged 65 and older with the diagnosis of systolic HF underwent a frailty assessment and blood sample collection for serum Gal-3 detection. A multivariable regression analysis and decision curve analysis (DCA) were used to identify significant predictors of frailty. Results: Frailty was present in 42.2% of patients. Age: Odds Ratio (OR) = 3.29; 95% Confidence Interval CI (CI) = 1.03-10.55, Cumulative Illness Rating Scale Comorbidity Index (CIRS-CI): OR = 1.85; 95% CI = 1.03-3.32, C-Reactive phase Protein (CRP) OR = 3.73; 95% CI = 1.24-11.22, N-terminal-pro-Brain Natriuretic Peptide (NT-proBNP): OR = 2.39; 95% CI = 1.21-4.72 and Gal-3: OR = 5.64; 95% CI = 1.97-16.22 resulted in being significantly and independently associated with frailty. The DCA demonstrated that the addition of Gal-3 in the prognostic model resulted in an improved clinical 'net' benefit. Conclusions: Circulating levels of Gal-3 are independently associated with frailty in elderly patients with systolic HF

Indexes of Angiogenic Activation in Myocardial Samples of Patients with Advanced Chronic Heart Failure

Background and objectives: Ischemic and idiopathic heart failure are characterized by reactive cardiac fibrosis and impaired vasculogenesis involving pro-angiogenic factors such as angiogenin, angiopoietin-1 (Ang-1), and angiopoietin-2 (Ang-2), as demonstrated in experimental models of heart failure. However, differences in the molecular pathways between these cardiomyopathies are still unclear. In this short communication, we evaluate and compare the expression of pro-angiogenic molecules in the heart tissue of patients with advanced chronic heart failure (CHF) of ischemic vs. nonischemic etiology. Materials and Methods: We obtained heart tissue at transplantation from left ventricular walls of 16 explanted native hearts affected by either ischemic (ICM) or nonischemic dilated cardiomyopathy (NIDCM). Tissue samples were examined using immunohistochemistry for angiogenic molecules. Results: We found immunopositivity (I-pos) for angiopoietin-1 mainly in the cardiomyocytes, while we observed I-pos for Ang-2 and Tie-2 receptor mainly in endothelial cells. Expression of Procollagen-I (PICP), angiogenin, Ang-1, and Tie-2 receptor was similar in ICM and NIDCM. In contrast, endothelial immunopositivity for Ang-2 was higher in ICM samples than NIDCM (p = 0.03). Conclusions: In our series of CHF heart samples, distribution of Ang-1 and angiogenin was higher in cardiomyocytes while that of Ang-2 was higher in endothelial cells; moreover, Ang-2 expression was higher in ICS than NIDCM. Despite the small series examined, these findings suggest different patterns of angiogenic stimulation in ICM and NIDCM, or at least a more altered endothelial integrity in ICD. Our data may contribute to a better understanding of the angiogenesis signaling pathways in CHF. Further studies should investigate differences in the biochemical processes leading to heart failure