5 research outputs found
Prevalence, genotype profile and risk factors for multiple human papillomavirus cervical infection in unimmunized female adolescents in Goiânia, Brazil: a community-based study
Submitted by Luciana Ferreira ([email protected]) on 2019-10-16T14:12:04Z
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Artigo - Rosane Ribeiro Figueiredo Alves - 2013.pdf: 484238 bytes, checksum: 9b42ea9ac32099a21c09b8b0f2d3a35b (MD5)
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Artigo - Rosane Ribeiro Figueiredo Alves - 2013.pdf: 484238 bytes, checksum: 9b42ea9ac32099a21c09b8b0f2d3a35b (MD5)
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Previous issue date: 2013Background: The epidemiology of infection with multiple human papillomavirus (HPV) types in female adolescents
is poorly understood. The purpose of this study was to explore the epidemiology of infection with multiple HPV
types in adolescents and its association with demographic, behavioral and biological variables, as well as with
cytological abnormalities.
Methods: This community-based study included 432 sexually active females between 15 and 19 years of age.
Genotyping for 30 HPV types was performed using a reverse blot strip assay/restriction fragment length polymorphism.
Unconditional multivariate logistic regression was performed to identify factors significantly associated with HPV
infection. The association between HPV infection and cytological abnormalities was calculated using a prevalence ratio.
Results: The most common HPV types detected were 16, 51, 31, 52 and 18. Of the 121 HPV-positive women, 54 (44.6%)
were infected with multiple HPV types. Having more than one lifetime sexual partner was associated with infection
with any HPV infection, single HPV infection, and infection with multiple HPV types. The presence of cytological
abnormalities was associated with infection with multiple HPV types.
Conclusions: Co-infecting HPV genotypes occur in a high proportion of sexually active adolescents. Socio-demographic
or sexual behavior factors associated with single HPV infection were similar to those associated with multiple HPV types.
The higher risk of cytological abnormalities conferred by infection with multiple HPV types suggests a potential role of
co-infection in the natural history of HPV infection
Sexually transmitted bacterial infections among young women in central western Brazil
Submitted by Luciana Ferreira ([email protected]) on 2019-10-16T13:49:42Z
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Artigo - Yanna Andressa Ramos de Lima - 2014.pdf: 354176 bytes, checksum: e9ba7e239b95fa8569b6586f544f4bf7 (MD5)
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Artigo - Yanna Andressa Ramos de Lima - 2014.pdf: 354176 bytes, checksum: e9ba7e239b95fa8569b6586f544f4bf7 (MD5)
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Artigo - Yanna Andressa Ramos de Lima - 2014.pdf: 354176 bytes, checksum: e9ba7e239b95fa8569b6586f544f4bf7 (MD5)
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Previous issue date: 2014Background: Studies on sexually transmitted infections in Brazil are done mainly in large metropolises
and screening is available for pregnant women only. We aimed to estimate the prevalence and risk
factors for Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum infection among young
non-pregnant women in non-clinical settings in middle-sized cities of Central Brazil.
Methods: A cross-sectional community-based sample of 1072 participants was included. Sexually active
women (64.9%) provided first-catch urine samples for PCR investigation of chlamydial and gonococcal
infection. Syphilis was tested in serum. Univariate analysis investigated risk factors for chlamydial
infection. Multivariate logistic regression included associations with a p-value <0.20.
Results: The mean age of participants was 18 years; 73.2% reported unprotected intercourse, 37.6% were
married/cohabiting, and 5% reported a previous STI. Prevalence rates of C. trachomatis, N. gonorrhoeae,
and T. pallidum were 9.6% (95% confidence interval (CI) 7.4–12.4%), 0.7% (95% CI 0.2–1.9%), and 0.15%
(95% CI 0.0–0.7%), respectively. After adjustments, being <20 years old (adjusted odds ratio (aOR) 1.90,
95% CI 1.07–3.37) and having three or more lifetime sexual partners (aOR 2.57, 95% CI 1.46–4.53) were
associated with the risk for chlamydial infection.
Conclusions: We observed a high prevalence of chlamydial infection and sexual risk behaviors in this
population. These findings are important to guide screening strategies in Brazil