Resilience of orbital angular momentum qubits and effects on hybrid entanglement

The orbital angular momentum of light (OAM) provides a promising approach for the implementation of multidimensional states (qudits) for quantum information purposes. In order to characterize the degradation undergone by the information content of qubits encoded in a bidimensional subspace of the orbital angular momentum degree of freedom of photons, we study how the state fidelity is affected by a transverse obstruction placed along the propagation direction of the light beam. Emphasis is placed on the effects of planar and radial hard-edged aperture functions on the state fidelity of Laguerre-Gaussian transverse modes and the entanglement properties of polarization-OAM hybrid-entangled photon pairs.Comment: 6 pages, 9 figure

Experimental generation and characterization of single-photon hybrid ququarts based on polarization-orbital angular momentum encoding

High-dimensional quantum states, or qudits, represent a promising resource in the quantum information field. Here we present the experimental generation of four-dimensional quantum states, or ququarts, encoded in the polarization and orbital angular momentum of a single photon. Our novel technique, based on the q-plate device, allows to prepare and measure the ququart in all five mutually unbiased bases. We report the reconstruction of the four dimensional density matrix through the tomographic procedure for different ququart states.Comment: 7 pages, 5 figure

Experimental optimal cloning of four-dimensional quantum states of photons

Optimal quantum cloning is the process of making one or more copies of an arbitrary unknown input quantum state with the highest possible fidelity. All reported demonstrations of quantum cloning have so far been limited to copying two-dimensional quantum states, or qubits. We report the experimental realization of the optimal quantum cloning of four-dimensional quantum states, or ququarts, encoded in the polarization and orbital angular momentum degrees of freedom of photons. Our procedure, based on the symmetrization method, is also shown to be generally applicable to quantum states of arbitrarily high dimension -- or qudits -- and to be scalable to an arbitrary number of copies, in all cases remaining optimal. Furthermore, we report the bosonic coalescence of two single-particle entangled states.Comment: 5 pages, 3 figure

Efficient generation and sorting of orbital angular momentum eigenmodes of light by thermally tuned q-plates

We present methods for generating and for sorting specific orbital angular momentum (OAM) eigenmodes of a light beam with high efficiency, using a liquid crystal birefringent plate with unit topological charge, known as \qo{q-plate}. The generation efficiency has been optimized by tuning the optical retardation of the q-plate with temperature. The measured OAM $m=\pm2$ eigenmodes generation efficiency from an input TEM$_{00}$ beam was of 97%. Mode sorting of the two input OAM $m=\pm2$ eigenmodes was achieved with an efficiency of 81% and an extinction-ratio (or cross-talk) larger than 4.5:1.Comment: 4 pages, 3 Figures and 1 table. Submitte

Quantum information transfer from spin to orbital angular momentum of photons

The optical "spin-orbit" coupling occurring in a suitably patterned nonuniform birefringent plate known as `q-plate' allows entangling the polarization of a single photon with its orbital angular momentum (OAM). This process, in turn, can be exploited for building a bidirectional "spin-OAM interface", capable of transposing the quantum information from the spin to the OAM degree of freedom of photons and \textit{vice versa}. Here, we experimentally demonstrate this process by single-photon quantum tomographic analysis. Moreover, we show that two-photon quantum correlations such as those resulting from coalescence interference can be successfully transferred into the OAM degree of freedom.Comment: 4 pages, 4 figure

Test of mutually unbiased bases for six-dimensional photonic quantum systems

In quantum information, complementarity of quantum mechanical observables plays a key role. If a system resides in an eigenstate of an observable, the probability distribution for the values of a complementary observable is flat. The eigenstates of these two observables form a pair of mutually unbiased bases (MUBs). More generally, a set of MUBs consists of bases that are all pairwise unbiased. Except for specific dimensions of the Hilbert space, the maximal sets of MUBs are unknown in general. Even for a dimension as low as six, the identification of a maximal set of MUBs remains an open problem, although there is strong numerical evidence that no more than three simultaneous MUBs do exist. Here, by exploiting a newly developed holographic technique, we implement and test different sets of three MUBs for a single photon six-dimensional quantum state (a qusix), encoded either in a hybrid polarization-orbital angular momentum or a pure orbital angular momentum Hilbert space. A close agreement is observed between theory and experiments. Our results can find applications in state tomography, quantitative wave-particle duality, quantum key distribution and tests on complementarity and logical indeterminacy.Comment: 8 pages, 4 figure

Deterministic qubit transfer between orbital and spin angular momentum of single photons

In this work we experimentally implement a deterministic transfer of a generic qubit initially encoded in the orbital angular momentum of a single photon to its polarization. Such transfer of quantum information, completely reversible, has been implemented adopting a electrically tunable q-plate device and a Sagnac interferomenter with a Dove's prism. The adopted scheme exhibits a high fidelity and low losses.Comment: 3 pages, 2 figure

Generation of hybrid polarization-orbital angular momentum entangled states

Hybrid entangled states exhibit entanglement between different degrees of freedom of a particle pair and thus could be useful for asymmetric optical quantum network where the communication channels are characterized by different properties. We report the first experimental realization of hybrid polarization-orbital angular momentum (OAM) entangled states by adopting a spontaneous parametric down conversion source of polarization entangled states and a polarization-OAM transferrer. The generated quantum states have been characterized through quantum state tomography. Finally, the violation of Bell's inequalities with the hybrid two photon system has been observed.Comment: 6 pages, 3 figure

Optimal quantum cloning of orbital angular momentum photon qubits via Hong-Ou-Mandel coalescence

The orbital angular momentum (OAM) of light, associated with a helical structure of the wavefunction, has a great potential for quantum photonics, as it allows attaching a higher dimensional quantum space to each photon. Hitherto, however, the use of OAM has been hindered by its difficult manipulation. Here, exploiting the recently demonstrated spin-OAM information transfer tools, we report the first observation of the Hong-Ou-Mandel coalescence of two incoming photons having nonzero OAM into the same outgoing mode of a beam-splitter. The coalescence can be switched on and off by varying the input OAM state of the photons. Such effect has been then exploited to carry out the 1 \rightarrow 2 universal optimal quantum cloning of OAM-encoded qubits, using the symmetrization technique already developed for polarization. These results are finally shown to be scalable to quantum spaces of arbitrary dimension, even combining different degrees of freedom of the photons.Comment: 5 pages, 3 figure

Pathologic response and survival after neoadjuvant chemotherapy with or without pertuzumab in patients with HER2-positive breast cancer: the Neopearl nationwide collaborative study

PurposeClinical trials have shown a significant increase in pathologic complete response (pCR) with the addition of pertuzumab to neoadjuvant chemotherapy for patients with early-stage HER-2 positive breast cancer. To date, limited studies have examined comparative outcomes of neoadjuvant pertuzumab in real-world setting. The Neopearl study aimed to assess comparative real-life efficacy and safety of neoadjuvant pertuzumab for these patients.MethodsWe conducted a nationwide retrospective analysis involving 17 oncology facilities with a certified multidisciplinary breast cancer treatment committee. We identified patients with HER-2 positive stage II-III breast cancer treated with neoadjuvant chemotherapy based on trastuzumab and taxanes with or without pertuzumab. All patients underwent breast surgery and received a comprehensive cardiologic evaluation at baseline and after neoadjuvant treatment. Patients who received the combination of pertuzumab, trastuzumab, and chemotherapy constituted case cohort (PTCT), whereas those treated with trastuzumab and chemotherapy accounted for control cohort (TCT). The pCR rate and 5-year event free survival (EFS) were the primary outcomes. Secondary end-points were rates of conversion from planned modified radical mastectomy (MRM) to breast conservation surgery (BCS) and cardiotoxicities.ResultsFrom March 2014 to April 2021, we included 271 patients, 134 (49%) and 137 (51%) in TCT and PTCT cohort, respectively. Positive axillary lymph nodes and stage III were more frequent in PTCT cohort. The pCR rate was significantly increased in patients who received pertuzumab (49% vs 62%; OR 1.74, 95%CI 1.04-2.89) and with HER-2 enriched subtypes (16% vs 85%; OR 2.94, 95%CI 1.60-5.41). After a median follow-up of 5 years, the 5-year EFS was significantly prolonged only in patients treated with pertuzumab (81% vs 93%; HR 2.22, 95%CI 1.03-4.79). The same analysis performed on propensity score matched population showed concordant results. On univariate analysis, only patients with positive lymph nodes were found to benefit from pertuzumab for both pCR and 5-year EFS. The rates of conversion from MRM to BCS and cardiologic toxicities did not differ between the cohorts.ConclusionOur findings support previous data on improved outcomes with the addition of pertuzumab to trastuzumab-based neoadjuvant chemotherapy. This benefit seems to be more significant in patients with clinically positive lymph nodes