Improving the investment potential management system of a construction company

The purpose of this paper is to improve the methodological provisions for managing the development of the investment potential of a construction company. As a result of the study, the characteristics of the main components of the investment potential of a construction company were determined, factors influencing its condition were identified and systematized. The key indicators and elements used in the study, including objectives, resources, abilities, opportunities and results, allow characterizing private potentials and provide maximum accuracy and reliability of the assessment. On this basis, a system for assessing the state, forecasting and managing the development of the investment potential of a construction company has been developed

Management of the innovation and investment cycles at the energy enterprises

The purpose of this paper is the substantiation and confirmation of the main provisions to the formation of instruments for the balanced development of the innovation and investment cycles at the energy enterprises. The basic principles of the balanced development of the innovation and investment cycles in the economic systems are determined, key problems of management of the balanced development of the innovation and investment cycles are identified and potential solutions are determined. Internal and external factors are analyzed, efficiency criteria for management are formed, and a mechanism for managing the balanced development of the innovation and investment cycle at the energy enterprises is developed

Design, construction and operation features of high-rise structures

The article considers design, construction and operation features of high-rise facilities. The analysis of various situations, that come from improper designing, construction and operation of unique facilities, is carried out. The integrated approach is suggested, when the problems of choosing acceptable constructional solutions related to the functional purpose, architectural solutions, methods of manufacturing and installation, operating conditions for unique buildings and structures are being tackled. A number of main causes for the emergency destruction of objects under construction and operation is considered. A number of measures are proposed on the basis of factor classification in order to efficiently prevent the situations, when various negative options of design loads and emergency impacts occur

Design, construction and operation features of high-rise structures

The article considers design, construction and operation features of high-rise facilities. The analysis of various situations, that come from improper designing, construction and operation of unique facilities, is carried out. The integrated approach is suggested, when the problems of choosing acceptable constructional solutions related to the functional purpose, architectural solutions, methods of manufacturing and installation, operating conditions for unique buildings and structures are being tackled. A number of main causes for the emergency destruction of objects under construction and operation is considered. A number of measures are proposed on the basis of factor classification in order to efficiently prevent the situations, when various negative options of design loads and emergency impacts occur

Management of the innovation and investment cycles at the energy enterprises

The purpose of this paper is the substantiation and confirmation of the main provisions to the formation of instruments for the balanced development of the innovation and investment cycles at the energy enterprises. The basic principles of the balanced development of the innovation and investment cycles in the economic systems are determined, key problems of management of the balanced development of the innovation and investment cycles are identified and potential solutions are determined. Internal and external factors are analyzed, efficiency criteria for management are formed, and a mechanism for managing the balanced development of the innovation and investment cycle at the energy enterprises is developed

Model management of innovative development of industrial enterprises

The purpose of the study is to develop the theoretical and methodological provisions, as well as the practical recommendations for the management of the innovative development of the industrial enterprises of a vertically integrated structure, which is considered as one of the mechanisms to improve its competitiveness. The article analyzes the technology of the innovative development of the economic systems, examines the current trends and identified the problems of the management of their innovative development, studies the technology of the management parameters of the life cycle of the products in the industrial enterprises and forms the criteria for the effectiveness of the innovative development management. The result of the study is the development of a structural and parametric model of the innovative enterprise management and the creation of a mechanism to improve the efficiency of its activities

Criteria approach to assessing the business stability of industrial and energy enterprises

The paper presents the results of the study in the field of ensuring the business stability of industrial and energy enterprises by determining the influence of external and internal factors. Identification of stability criteria was carried out by an expert survey using a simple but reliable mathematical apparatus. The final integral indicator of the economic stability of an industrial enterprise was obtained by a calculation and expert method using economic and mathematical modeling. The proposed method is quite universal and can be used to assess the stability of an enterprise over time, as well as to compare the stability of several enterprises with each other

Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial

Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI. Interpretation: In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes