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Mechanistic Study of Direct Arylation of Indole Using Differential Selectivity Measurements: Shedding Light on the Active Species and Revealing the Key Role of Electrophilic Substitution in the Catalytic Cycle
Differential selectivity
of the direct arylation of indole with
aryl halides under competing and noncompeting conditions with a varying
set of reaction parameters was determined using phase trajectories.
The results described herein allow for conclusions to be drawn regarding
the character of active complexes (cationic, neutral, or anionic)
as well as realization of the indole electrophilic substitution in
the catalytic cycle using the ligand-free catalytic system